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Vasoconstrictors: Chemistry, Mode of Action, and Dosage
Published in Marwali Harahap, Adel R. Abadir, Anesthesia and Analgesia in Dermatologic Surgery, 2019
Binding of ornipressin to the V1a receptors results in activation of Gs protein, phospholipase C activation, and vasoconstriction. Most studies have shown that ornipressin is similar in effect to adrenaline with regard to vasoconstriction, with fewer side effects (37).
Renal and Hepatic Disease: Cnidoscolus aconitifolius as Diet Therapy Proposal for Prevention and Treatment
Published in Journal of the American College of Nutrition, 2021
Maria Lilibeth Manzanilla Valdez, Maira Rubi Segura Campos
The treatment with vasoconstrictors and albumin is one of the first options to choose. The goal of treatment is to produce vasoconstriction in the splenic vascular bed and reduce hypovolemia.Alpha adrenergic agonists: norepinephrine, midrodine. Norepinephrine is a catecholamine that acts on adrenergic receptors. Midodrine acts as a selective agonist of peripheral alpha-1 receptors, generating vasoconstriction and increased blood pressure (55).Somastostin analogues: Octreotide, an octapeptide analogous to somastatin with potent vasoconstrictor action on the splenic vasculature. It acts as an inhibitor of the secretion of peptides synthesized by the gastro-endocrine-pancreatic endocrine system, having the effect of decreasing splenic blood flow (55).Vasopressin analogues: ornipressin, terlipressin. Ornipressin has shown benefits in SHR, but due to its ischemic effects such as arrhythmias, myocardial ischemia and cutaneous necrosis, it has been abandoned. Terlipressin is a synthetic derivative of vasopressin, which has a dominant action on V1 receptors, with a potent vasoconstrictor effect. The administration of volume expanders such as albumin improve the effect of vasoconstrictors (54).