Concomitant drugs

Concomitant drugs

A concomitant drug refers to any medication or substance that is taken alongside another drug, which may cause changes in the way the drugs are absorbed, metabolized, distributed, or excreted, leading to potential alterations in their efficacy and safety. The intake of concomitant drugs is considered a significant confounding factor that may affect the outcome of a treatment.From: Statin use and safety concerns: an overview of the past, present, and the future [2020], Herbal Supplements-Drug Interactions [2019]

Plant-Based Adjunct Therapy for Tuberculosis

View Chapter

Purchase Book

Published in Namrita Lall, Medicinal Plants for Cosmetics, Health and Diseases, 2022

Lydia Gibango, Anna-Mari Reid, Jonathan L. Seaman, Namrita Lall

Drug–drug interactions occur when the effect of one drug is affected by the presence of a concomitant drug (Magro et al., 2012). These drug interactions may cause adverse drug reactions which, for the most part, are predictable and can be avoided. However, prevention is very complex in practice due to the high number of drugs that could potentially interact with one another (Létinier et al., 2019).

Statin use and safety concerns: an overview of the past, present, and the future

View Article

Journal Information

Published in Expert Opinion on Drug Safety, 2020

Rubina Mulchandani, Tanica Lyngdoh, Ashish Kumar Kakkar

Statins are usually prescribed in combination therapy, often with other medications for cardiovascular risk reduction. Interactions between concomitant drugs may cause alterations in the absorption, metabolism, distribution, or excretion, thus affecting the efficacy and safety of either or both drugs. The most prominent concern associated with such adverse drug interactions is the risk of myopathy and rhabdomyolysis usually seen with drugs that interfere with statin metabolism or hepatic uptake [31,117].

Explore chapters and articles related to this topic

Plant-Based Adjunct Therapy for Tuberculosis

Statin use and safety concerns: an overview of the past, present, and the future