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Therapeutic Potential of Nigella sativa (Black Seed)
Published in Mehwish Iqbal, Complementary and Alternative Medicinal Approaches for Enhancing Immunity, 2023
Exploratory studies have shown that extracts of Nigella sativa have synergistic effects on the elimination of Escherichia coli along with antibiotic medicines, for instance, streptomycin, doxycycline, chloramphenicol, gentamycin, nalidixic acid, ampicillin, cephalexin and terbinafine (Morsi, 2000; Ara et al., 1970). Moreover, black seed has inhibitory effects on bacterial growth such as Corynebacterium pseudotuberculosis, Staphylococcus aureus, Yersinia enterocolitica, Brucella abortus, Escherichia coli, Trueperella pyogenes, Listeria monocytogenes, Corynebacterium renale, Pasteurella multocida and Mannheimia haemolytica. Another study has revealed that black seed oil has an antistaphylococcal activity similar to that of antibiotics such as cefaclor, ceftazidime, cefamandole and cefuroxime (Kooti et al., 2016).
Infective endocarditis by Actinomyces species: a systematic review
Published in Journal of Chemotherapy, 2023
Petros Ioannou, Stella Baliou, Ioanna Papakitsou, Diamantis P. Kofteridis
Actinomyces species are Gram-positive bacteria that colonize the mouth, colon, and vagina and are the causes of actinomycosis, which is a slowly progressive infection that may mimic malignancy due to the invasiveness of tissues and the ability to form sinus tracts [1]. The most common encountered species associated with actinomycosis is A. israeilii [2]. Other species that may also cause actinomycosis, even though they are less frequently encountered are Actinomyces naeslundii, Actinomyces viscosus, Actinomyces odontolyticus, Actinomyces gerencseriae, Actinomyces graevenitzii, and Actinomyces meyeri [3–9]. With development of newer methods for pathogen identification, such as MALDI-TOF and genotypic methods such as comparative 16S ribosomal RNA (rRNA), new Actinomyces species have been identified from both human and animal specimens [6,10,11]. On the other hand, some Actinomyces species have been reclassified as Trueperella, Actinotignum, or Cellulomonas due to the same pathogen identification methods [6,10–14].
Single-dose intravesical amikacin instillation for pyocystis in a patient with autonomic dysreflexia: A case report
Published in The Journal of Spinal Cord Medicine, 2022
Erin Sherwin, Cynthia King, Howard Hasen, Shari May
Current data to support intravesical aminoglycoside irrigations for infections of the urinary tract are limited to case reports and observational studies. Elsayed and colleagues reported the use of gentamicin irrigations to treat pyocystis in a 68-year-old male with ESRD on hemodialysis.9 The infective organism was Trueperella bernardiae, a Gram-positive opportunistic pathogen. The patient received IV ceftriaxone with intravesical gentamicin and normal saline irrigations three times daily for a total of 4 days. The patient’s symptoms improved and he was transitioned to oral cefuroxime for 5 days. Wood and colleagues reported a case of a 69-year-old female treated with continuous tobramycin irrigations (40 mg/1,000 mL in sterile water) at 42 mL/hour for a total of 4 days. Follow-up urine culture revealed no growth of the infective organism Enterobacter cloacae.10 A report from Gonzalez and colleagues describes the use of continuous amikacin irrigations for E. coli cystitis emphysematous in a 60-year-old female.11 She also received IV amikacin and ceftriaxone. Treatment resulted in eradication of the organism.
Device safety assessment of bronchoscopic microwave ablation of normal swine peripheral lung using robotic-assisted bronchoscopy
Published in International Journal of Hyperthermia, 2023
Hector De Leon, Kevin Royalty, Louie Mingione, David Jaekel, Sarvesh Periyasamy, David Wilson, Paul Laeseke, William C. Stoffregen, Tim Muench, John P. Matonick, Grzegorz L. Kaluza, Gustavo Cipolla
The primary pathogen of enzootic pneumonia, a chronic respiratory disease in pigs, is M. hyopneumoniae [66]. In our study, 3 animals were positive for M. hyopneumoniae and bacterial cultures from lung samples of a 3-Day animal (ID: 13) also tested positive for Streptococcus suis and Trueperella pyogenes. Thus, the model propensity to endemic infectious diseases and potential exacerbation of secondary infections, and the potential need for extended use of prophylactic antibiotics should be taken into consideration when using this animal model. Further studies are warranted to investigate the need of prophylactic antibiotic therapy in the clinical setting before performing bronchoscopic MWA.