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Posterior uveitis
Published in Gwyn Samuel Williams, Mark Westcott, Carlos Pavesio, Bushra Thajudeen, Practical Uveitis, 2017
Gwyn Samuel Williams, Mark Westcott
These two conditions will be taken together due to similarities between the two. Indeed some authors have suggested they are a spectrum of the same condition. Multifocal choroiditis with panuveitis (MCP) presents, as the name suggests, with panuveitis which by definition means that the anterior uveal tract is involved, as well as there being obvious vitritis present. The dots or spots are very easy to spot and are usually a mix of older pigmented scars and newer fluffier whiter lesions less than a disc diameter across and usually located in the fundus outside of macula (Figure 5.5). It is said to be a bilateral condition but not infrequently patients do present with unilateral involvement. A hallmark of this condition is the peripapillary presence of lesions which may also be associated with optic disc swelling.
Clinical Manifestations and Treatment of Vogt–Koyanagi–Harada Disease during Pregnancy and after Birth: A Case Report
Published in Ocular Immunology and Inflammation, 2023
José L. Sanchez-Vicente, Antonio Moruno-Rodríguez, Juan De las Morenas-Iglesias, Bosco Gonzalez-Jauregui, Carolina Franco-Ruedas, Beatriz Lechon-Caballero, Arturo Talego-Sancha, Trinidad Rueda-Rueda, Aurora Del Estad-Cabello, Fernando López-Herrero
In this case, even though initial presentation could suggest other inflammatory or non-inflammatory conditions, the follow-up and subsequent clinical and imaging exams supported the final diagnosis of incomplete Vogt-Koyanagi-Harada. After excluding infectious causes, the well-defined choroidal foci could remind the diagnosis of multifocal choroiditis with panuveitis or sarcoidosis. Multifocal choroiditis with panuveitis usually presents with mild to moderate anterior chamber inflammation and has multiple yellow-whitish medium size choroidal lesions in different stages. The most frequent complications in the posterior pole are cystic macular oedema and the appearance of epiretinal membranes, not the appearance of serous retinal detachments with the formation of subretinal septa. For ocular sarcoidosis diagnosis there should be at least some systemic findings not found in this patient besides further ocular clinical signs other than bilaterality and multiple chorioretinal lesions. Further cerebrospinal fluid analysis and fluorescein angiography in the early acute phase could add to Vogt-Koyanagi-Harada disease diagnosis.
Distinct Patterns of Choroidal Lesions in Punctate Inner Choroidopathy and Multifocal Choroiditis Determined by Heatmap Analysis
Published in Ocular Immunology and Inflammation, 2022
Jong G. Park, Muhammad Sohail Halim, Gunay Uludag, Neil Onghanseng, Nripun Sredar, Yasir J. Sepah, Quan Dong Nguyen
Punctate inner choroidopathy (PIC), multifocal choroiditis (MFC), and multifocal choroiditis and panuveitis (MCP) are a group of inflammatory conditions classically characterized by multiple yellow-white lesions at the level of the choroid or retinal pigment epithelium (RPE) in the absence of systemic disease. These clinical features were first described by Nozik and Dorsch,1 who observed fundus lesions similar in appearance to presumed ocular histoplasmosis syndrome but with the distinction of cells in the anterior chamber. The condition was expanded upon by Dreyer and Gass,2 who described episodes of recurrent inflammation in these patients and coined the term “multifocal choroiditis and panuveitis.” Around the same time, Watzke et al.3 characterized patients with similar fundus findings but no evidence of inflammation as having a separate condition which they termed “punctate inner choroidopathy.”
Punctate Inner Choroidopathy and Choroidal Neovascularization in Korean Patients
Published in Ocular Immunology and Inflammation, 2020
Ji Hwan Lee, Sung Chul Lee, Seo Jin Park, Christopher Seungkyu Lee
We retrospectively reviewed the medical records of 26 patients diagnosed with PIC between April 2004 and December 2015. PIC was diagnosed on the basis of clinical and multimodal imaging features. Eyes with typical gray or yellow, small round lesions or punched-out atrophic chorioretinal scars without signs of anterior uveitis or vitritis were included.6 Eyes with a history of inflammatory cells in the anterior chamber or vitreous cavity observed on ophthalmoscopy or spectral domain OCT (SD-OCT) were diagnosed with multifocal choroiditis with panuveitis (MCP) and excluded from the present study.11 Other white dot syndromes, including acute zonal occult outer retinopathy, diffuse subretinal fibrosis, acute posterior multifocal placoid pigment epitheliopathy, multiple evanescent white dot syndromes, and pathologic myopia, were also excluded. Fluorescent treponemal antibody absorption test, interferon-gamma release assay, and chest X-ray were performed to exclude infectious causes of posterior uveitis such as syphilis and tuberculosis. This study was approved by the Institutional Review Board of Severance Hospital, Yonsei University College of Medicine.