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Antibody-Based Therapies
Published in David E. Thurston, Ilona Pysz, Chemistry and Pharmacology of Anticancer Drugs, 2021
In the clinical trials, the adverse events were sufficiently manageable to allow patients to have weekly doses for two weeks within a three-week cycle. The main side effects are neutropenia and diarrhea which can become dose-limiting, and the product carries a boxed warning regarding the risk of severe neutropenia and diarrhea. It may also cause harm to a developing fetus or new born, and so appropriate contraceptive and breastfeeding guidance must be adhered to.
The Non-Prescription Products – Market-Profits and Public Health in Conflict
Published in Mickey C. Smith, E.M. (Mick) Kolassa, Walter Steven Pray, Government, Big Pharma, and the People, 2020
What is the real reason behind the PA/NDMA/CHPA’s leadership in defeating the proposals for a third class of Drugs? Their charge that druggists would have a monopoly is undoubtedly part of it, but there may be far-deeper objections that they will not voice aloud. The PA members have spent untold billions advertising their products directly to consumers. The Advertising has one easily stated message to the Public, “Go out immediately and buy our products. No other product should be considered”. When OTCs are available in any location, there is no university-educated pharmacist to tell patients that a specific product is not the best medical choice. Under a third class of Drugs, patients would be forced to approach a pharmacist for advice, and the pharmacist might invalidate this message and change the consumer’s mind. Any of the following could occur: The pharmacist might triage the patient to a physician, dentist, or other Health professional for further diagnostic work.The pharmacist might advise the patient that no product is needed.The pharmacist might advise the consumer to buy a competitor’s product.
Quality Control of Ayurvedic Medicines
Published in D. Suresh Kumar, Ayurveda in the New Millennium, 2020
V. Remya, Maggie Jo Alex, Alex Thomas
In ancient times, physicians having comprehensive knowledge of bhaiṣajya kalpana (ayurvedic pharmacy) used to prepare the medicines themselves to treat their patients. Therefore, there was no difficulty in obtaining authentic medicines with desired therapeutic properties. However, in modern times, industrialization has compelled physicians to depend on commercially manufactured ayurvedic medicines. Thus, now there is the need for standardization of these medicinal preparations. The quality of ayurvedic medicines can be improved by utilizing herbs collected at appropriate seasons and stored under specified conditions. Certain toxic herbs like Plumbago zeylanica (root) and Semecarpus anacardium (seed) need to be subjected to detoxification-cum-potentiation processes (śōdhana), so that the appearance of undesirable side-effects can be prevented. Good manufacturing practices and standard processes are to be adopted in the manufacture of medicines, a responsibility that should rest with qualified and experienced personnel. The manufactured products should be packed and stored under specific conditions. The quality of crude drugs and finished products needs to be established using physicochemical tests and fingerprinting techniques.
Skin, hair, and nail supplements advertised on Instagram
Published in Baylor University Medical Center Proceedings, 2023
Dina H. Zamil, May Ameri, Shangyi Fu, Ferris M. Abughosh, Rajani Katta
To better advise patients, healthcare professionals must understand the promotion of health and dermatologic products on social media. American consumers,1 especially teens and young adults,2 often turn to the internet for health information. Further, international research suggests that social media is becoming increasingly relevant as a source for health-related information for young people.3,4 One topic of increasing interest to consumers is that of skin, hair, and nail supplements, which are often advertised on social media and endorsed by celebrities. Research indicates that dietary supplements are commonly used specifically for dermatological purposes. A recent study of the National Health and Nutrition Examination Survey illustrated that nearly 88% of respondents using dietary supplements reported taking them for healthy skin, hair, and nails.5 Although they can be pharmacologically active, these products are not regulated as drugs by the Food and Drug Administration (FDA) in the United States.6 Reports have also linked these products to adverse effects, such as birth defects, toxicity, allergies, and drug interactions.7,8 The objective of this study was to investigate Instagram posts related to skin, hair, and nail supplements with regards to ingredients mentioned, endorsements, and health claims.
Exposure to hand sanitisers and other cleaning products in Victoria, Australia during the COVID-19 pandemic
Published in Clinical Toxicology, 2022
Alice Norvill, Rohan A. Elliott, Anselm Wong
The potential harms associated with these products are well described. For example, hand sanitisers typically contain between 60% to 95% alcohol or isopropyl alcohol. Ingestion can have serious consequences, including central nervous system depression, hypoglycaemia, apnoea, acidosis, coma, and in rare cases, death [7,8]. Ocular exposures have the potential to cause corneal or conjunctival ulcers. In France, ocular exposures to alcohol-based hand sanitisers in children under 18 years were found to be seven times higher during the period of April to August 2020 compared to 2019 [11]. Despite the potential for harm, research undertaken during the COVID-19 pandemic by the Centers of Disease Control and Prevention in the US found that only 54% of respondents were aware that hand sanitisers should be kept out of reach of children [12].
Saudi consensus statement on biologic treatment of chronic plaque psoriasis (2020)
Published in Journal of Dermatological Treatment, 2022
Mohammad Ibrahim Ahmad Fatani, Issam Ribhi Ahmad Hamadah, Mohammed Abdulaziz Alajlan, Yousef Binamer, Aymen Hamed Salem Alharbi, Amaal Farhan Salman Alruwaili, Maha Abdulrahman Abdulateef Aldayel, Khalidah Ahmed Owdetallah Alenzi, Sultan Mohammed Mubarki, Amr Mohammad Khardaly, Bedor Abdullah Abdulrahman Alomari, Hajer Yousef Almudaiheem, Ahmed Al-Jedai, Maysa Tariq Yousef Eshmawi
Clinical practice guidelines are evidence-based decision-making tools for managing health conditions. They are based on the best information available at the time of writing and are to be updated regularly. The present guidelines are not meant to serve as strict treatment guidelines. They are also not intended to replace the clinical judgment of practicing physicians but are only tools to help manage patients who require biologic psoriasis treatment. Decisions concerning treatment must always be taken on a case-by-case basis and the prescribing physicians need to personalize care and tailor the treatment regimen to patients’ personal circumstances and medical history. Physicians should also consult the approved product monographs within their institution’s formulary for each drug for dosage, special warnings and precautions for use, contraindications, and monitoring of side effects and potential harms. Institution formulary restrictions may also need to be considered when selecting treatment options. Prescribing physicians should refer to their institution’s formularies during the decision-making process for choosing specific agents within a recommended specific class.