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Orders Norzivirales and Timlovirales
Published in Paul Pumpens, Peter Pushko, Philippe Le Mercier, Virus-Like Particles, 2022
Paul Pumpens, Peter Pushko, Philippe Le Mercier
It is noteworthy, however, that the phage AP205, due to the initiative of Kaspars Tārs’s group, served as a model by the pioneering 3D studies using solid-state nuclear magnetic resonance under ultrafast magic-angle spinning (MAS; Barbet-Massin et al. 2013, 2014; Andreas et al. 2015). At last, dynamic nuclear polarization (DNP) made it possible to overcome the sensitivity limitation of the MAS NMR experiments (Jaudzems et al. 2018). Thus, the high-quality DNP-enhanced NMR spectra were obtained for the phage AP205 by combining high magnetic field (800 MHz) and fast MAS (40 kHz).
Health and Healthcare Education Current State
Published in Connie White Delaney, Charlotte A. Weaver, Joyce Sensmeier, Lisiane Pruinelli, Patrick Weber, Deborah Trautman, Kedar Mate, Howard Catton, Nursing and Informatics for the 21st Century – Embracing a Digital World, 3rd Edition, Book 2, 2022
Jane Marie Kirschling, Mary Etta Mills
The expansion of graduate education, and especially doctoral education, in nursing in the United States is also noteworthy and will continue to require schools of nursing to assure that the curricula for the various avenues for preparing nurses for advanced nursing practice and for careers as nurse scientists are responsive to the needs of the ever-evolving healthcare system. A recommendation in the 2011 report The future of nursing was to double the number of doctorally prepared nurses by 2020, this recommendation has been far exceeded. While enrollment in 146 research-focused doctoral programs decreased by 5.9% between 2016 (4,883 students) and 2020 (4,597 students), enrollment in 378 Doctorate of Nursing Practice (DNP) programs increased by 56.3% (2016 25,258 students, 2020 39,485 students) (Smiley et al., 2021, pp. 53, 66). The growth in DNP programs has placed considerable pressure on faculty resources as programs have worked to assure that they were meeting The Essentials of Doctoral Education for Advanced Nursing Practice and especially the requirement of a final DNP project (AACN, 2006). In addition, the advanced practice registered nurse programs have to meet the requirements of the various specialties. All of the DNP curricula, including BSN-to-DNP and post-master's DNP, will have to be re-envisioned given the 2021 Essentials.
Envisioning Digital Health and Nursing's Call to Lead Unparalleled Transformation of Person-centered, Connected and Accessible Care
Published in Connie White Delaney, Charlotte A. Weaver, Joyce Sensmeier, Lisiane Pruinelli, Patrick Weber, Nursing and Informatics for the 21st Century – Embracing a Digital World, 3rd Edition, Book 4, 2022
Connie White Delaney, Charlotte A. Weaver, Joyce Sensmeier, Lisiane Pruinelli, Patrick Weber
Faculty professional development is mandatory and the existing informatics specialty organizations could provide valuable assistance. Faculty teaching in nursing informatics graduate specialization programs should be knowledgeable and experienced informaticians with the academic background to address essential content. In the US, the growth in DNP programs has placed considerable pressure on faculty resources, as programs have worked to assure that they were meeting the essentials of doctoral education for advanced nursing practice including the requirement of a final DNP project (AACN, 2006). In addition, the advanced practice registered nurse programs have to meet the requirements of the various specialties. All of the DNP curricula, including BSN-to-DNP and post-master's DNP, are currently being revised to comply with the 2021 AACN Essentials (American Association of Colleges of Nursing, 2021). Courses that simply provide an overview of informatics as a specialty are no longer sufficient. Courses directed at successfully incorporating informatics and information and communication technologies must align these skills and best practices to care delivery, best communication processes and operational workflows.
First-in-human phase I studies of YJ001 spray applied to local skin in healthy subjects and patients with diabetic neuropathic pain
Published in Expert Opinion on Investigational Drugs, 2023
Xiding Yang, Ronghua Zhu, Jing Zhang, Zaihua Hou, Lingfeng Yang, Xiao Fan, Qiangyong Yan, Jingjing Li, Zhiguang Zhou, Pingfei Fang
The exact mechanism underlying DNP is not yet clearly understood. Neuroinflammation caused by hyperglycemia [13,14] and neurological damage to the function of sensory fibers [12,15,16] are postulated to be the two main causes of DNP. The test drug, YJ001 spray, is a stable pharmaceutical composition containing non-steroidal anti-inflammatory drug derivative, designed and developed by Zhejiang Yuejia Pharmaceuticals Co., Ltd., China [17]. Studies on the mechanism of action in vitro(unpublished data provided by Yuejia Pharmaceuticals) have found that YJ001 can inhibit the expression of inflammatory cytokines induced by advanced glycation endproducts (AGEs). In addition to its anti-inflammatory effects, YJ001 can directly play an analgesic role by stabilizing the abnormally excitable neuronal membrane potential and reducing ectopic discharges through voltage‑gated sodium channels.YJ001 might have a potential therapeutic effect on DNP through both anti-inflammatory and analgesic effects. Additionally, toxicology and pharmacodynamics studies in animal models of diabetic peripheral neuralgia have shown that YJ001 spray administered topically to the skin is well-tolerated and might have a good analgesic effect. Pharmacokinetic experiments in animals showed that YJ001 metabolites, including YJ001-A and YJ001-C, were mainly distributed in local tissues (skin, subcutaneous fat, and subcutaneous muscle) after local administration of YJ001 spray. The metabolites of YJ001 can also be detected in the plasma, indicating systematic exposure.
Does the DSW Practice Doctorate Provide Opportunities for Closing Gaps in Gerontology?
Published in Journal of Gerontological Social Work, 2019
Nicole Ruggiano, Javonda Williams
In moving forward with DSW education, social work has not carved-out areas of the field that are specific to DSW-trained practitioners. This has raised concerns and questions about how the DSW is different than the MSW or general concerns about the role of the MSW in the field after the DSW becomes more common-place. Looking at the field of nursing, one could argue that the MSW will not be obsolete as more practitioners obtain DSW degrees. Among health-related professions with doctoral-level practitioners, nursing is similar to the field of social work in that it supports both advanced master’s and advanced doctorate degrees (Seegmiller, Nasypany, Kahanov, Seegmiller, & Baker, 2015). Doctor of Nursing Practice (DNP) graduates often hold positions, such as nurse practitioners and have advanced training to work more independently and to take on additional roles from master-level nurses. However, the role of RN or master’s-level advanced nursing education did not become obsolete once the DNP became more common in the health field. Rather replacing the role of RNs, it is asserted that more nurse practitioners are needed to address the shortage of primary care physicians (Bodenheimer & Smith, 2013). Controversies surrounding the role of the DNP have more surrounded the issue regarding the roles that nurse practitioners play in relation to primary care physicians. If social work follows suit, what unique roles could DSW-trained fill? How do we define the role of DSW-level practitioners within health and support service settings for older adults?
Anxiety, depression and sleep disorders in patients with diabetic neuropathic pain: a systematic review
Published in Expert Review of Neurotherapeutics, 2019
Cristina Naranjo, Leticia Del Reguero, Guillermo Moratalla, Miguel Hercberg, Marta Valenzuela, Inmaculada Failde
There are some limitations to be taken into account in this review. Firstly, although all the articles included contained some information about patients with DNP, not all of them provided data about all of the comorbidities reviewed, depression being the most widely studied. Likewise, the method used for the diagnosis of DNP varies between the studies, which could influence the results obtained. However, since the criterion used for including articles was that the patients were diagnosed with DNP we think that this bias should not affect the results.