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Hypothyroidism
Published in Vincenzo Berghella, Maternal-Fetal Evidence Based Guidelines, 2022
Levothyroxine is the recommended thyroid replacement therapy in pregnant hypothyroid women. Other thyroid preparations such as T3 or desiccated thyroid extract should be avoided during pregnancy [3, 23].
Hypothyroidism
Published in David S. Cooper, Jennifer A. Sipos, Medical Management of Thyroid Disease, 2018
Synthetic LT3 preparations are similarly identical to the T3 produced by the human thyroid gland. Desiccated thyroid extract (DTE) preparations are made by drying and powdering animal thyroid glands. The most common forms of DTE come from porcine thyroid glands. DTE products consist of about 80% T4 and 20% T3 (approximately a 4:1 ratio of T4 to T3). The T4 to T3 ratio may vary somewhat in DTE products, depending on the brand and manufacturing process (61).
Benign Thyroid Disease
Published in John C Watkinson, Raymond W Clarke, Louise Jayne Clark, Adam J Donne, R James A England, Hisham M Mehanna, Gerald William McGarry, Sean Carrie, Basic Sciences Endocrine Surgery Rhinology, 2018
Christopher M. Jones, Kristien Boelaert
A minority of patients feel that their symptoms of hypothyroidism are not controlled on thyroxine therapy despite normal concentrations of TSH and T4. Some choose to take T3 in addition to or instead of thyroxine, although due to its rapid absorption and short half-life it must be taken three times a day and fluctuations in thyroid hormone levels exist. Current national and international guidance does not recommend the use of T3 monotherapy or T3/T4 combination therapy in the management of hypothyroidism based on the lack of evidence supporting these treatment strategies.127, 128 Similarly, the use of desiccated thyroid extract is not advisable.129
Triiodothyronine alongside levothyroxine in the management of hypothyroidism?
Published in Current Medical Research and Opinion, 2021
Ulrike Gottwald-Hostalek, George J. Kahaly
Many patients with thyroid disorders are avid consumers of social media, and there is no doubt that exposure to these sources influences their perceptions of hypothyroid management, including the use of non-evidence-based approaches59,60. A feeling of not being listened to by physicians, and persistence of symptoms, have been identified as important drivers of the use of desiccated thyroid extract among social media users with hypothyroidism, although about half of this sample claimed to have derived their initial interest in this approach from their physician59. Self-adjustment of these medications by patients, driven by symptoms, is also common61. Given the interest in the use of T3 preparations within thyroid disease management from both physicians and patients, it is perhaps unsurprising that their use in routine practice is widespread and increasing61.