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Immunologically mediated skin disorders
Published in Rashmi Sarkar, Anupam Das, Sumit Sethi, Concise Dermatology, 2021
A comprehensive history is of utmost importance. It includes the type of lesions, duration, pruritus, systemic symptoms (like hoarseness, dyspnea, abdominal pain, and arthralgia), and medications. ASST (autologous serum skin test) and anti FcεRIα antibody determination can be done for autoimmune urticaria. Dermographism is evoked by skin stroking; pressure urticaria by application of weight to the skin; vibratory angioedema by a vibratory stimulus; cholinergic urticaria can be diagnosed by exercise to sweating; solar urticaria by testing with UVB, UVA, and visible light; cold urticaria by application of ice cube to skin. Urticarial vasculitis can be diagnosed by histopathology showing features of vasculitis. Complement levels can also be helpful.
Symptomatic dermographism in Chinese population: an epidemiological study of hospital-based multicenter questionnaire survey
Published in Current Medical Research and Opinion, 2022
Lijuan Liu, Xin Wang, Wenjuan Wang, Bin Wang, Linfeng Li
Comparing the situation of SD with other types of urticaria in the north and south, the incidence of SD patients with chronic spontaneous urticaria in the south (68.5%) is lower than that in the north (76.8%), and the difference is statistically significant; In contrast, the incidence of SD patients with angioedema (22.1% vs. 4.7%), SD patients with delayed pressure urticaria (16.2% vs. 0.5%), SD with pyrogenic urticaria (7.8% vs. 1.6%) and SD patients with solar urticaria (4.9% vs. 0.0%) was higher in the south than those in the north (p < .05); while the incidence of simple SD and SD accompanied by cold urticaria, SD with vibratory angioedema and SD with water-borne urticaria were not different between the south and the north (p > .05). The results are shown in Table 4.
Opportunities and challenges for drug discovery in modulating Adhesion G protein-coupled receptor (GPCR) functions
Published in Expert Opinion on Drug Discovery, 2020
Andrey D. Bondarev, Misty M. Attwood, Jörgen Jonsson, Vladimir N. Chubarev, Vadim V. Tarasov, Helgi B. Schiöth
For the purpose of this review, the term ‘miscellaneous disorder’ encompasses conditions affecting the sensory, dermal, endocrine, and cardiovascular systems. The respective conditions are type 2 C Usher syndrome (USH2 C), vibratory angioedema (VA), type 2 diabetes (T2DM), congenital heart disorders (CHDs), coronary artery disease (CAD), and myocardial infarction (MI). USH2 C is an autosomal recessive development disorder found to be associated with ADGRV1 and characterized by typically moderate congenital hearing loss and retinitis pigmentosa [168,169]. The ADGRV1 receptor is expressed in the eye and cochlear tissues and believed to be associated with ankle links, present in the vestibular and auditory bundles, and play important roles in their development as a component of connecting filaments [170]. A number of diverse disease-relevant mutations in ADGRV1 are reported and mapped across the N-terminal domain and typically result in a truncated protein [171,172]. Among the most recent discoveries is a nonsense mutation that is predicted to create a premature stop codon near the receptor’s N-terminus which prevents 7TM translation [173]. There are currently no conclusive data on receptor–ligand interactions for ADGRV1; however, it has been found that extracellular Ca2+ may interact with ADGRV1 to activate protein kinases A and C via Gαs and Gαq, respectively [174]. Another study has shown that the ICD fragment of ADGRV1 has a particularly strong inhibitory effect on the adenylate cyclase pathway as the Y6244fsX1 mutation in the ICD improved the receptor’s Gαi coupling [175].