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Skin and soft tissue
Published in Tor Wo Chiu, Stone’s Plastic Surgery Facts, 2018
KMS is a sequestration of platelets leading to thrombocytopaenia, localised consumption coagulopathy and DIC with a mortality rate of 30%–40%. It is associated with haemangioendothelioma or tufted angioma and not the common types of IH.
Vascular tumours and malformation
Published in Brice Antao, S Irish Michael, Anthony Lander, S Rothenberg MD Steven, Succeeding in Paediatric Surgery Examinations, 2017
Cameron C Trenor III, Steven J Fishman, Arin K Greene
Infantile haemangioma appears within the first 2 weeks of life and enlarges rapidly for several months; after 1 year of age it begins to slowly regress. Rapidly involuting congenital haemangioma is a purplish lesion that is present at birth and has completely regressed by 1 year of age. Non-involuting congenital haemangioma is a purplish lesion present at birth that does not undergo involution. Kaposiform haemangioendothelioma cutaneous lesions are firm and purple, may be present at birth or arise in infancy and are often complicated by severe thrombocytopenia and bleeding. Tufted angioma is a milder tumour on the same neoplastic spectrum as kaposiform haemangioendothelioma. Angiosarcoma is a malignant neoplasm with a high mortality rate, typically occurring in adults. Epithelioid haemangioendothelioma may be a low- or a high-grade malignancy and usually affects the liver, lungs and bone. Pyogenic granuloma is a small vascular lesion that commonly affects the face of children at an average age of 6 years; it frequently causes bleeding. Cutaneovisceral angiomatosis with thrombocytopenia is often present at birth and is associated with multiple cutaneous lesions, thrombocytopenia and gastrointestinal bleeding due to visceral lesions.
Hepatic tumors
Published in Prem Puri, Newborn Surgery, 2017
Benjamin A. Farber, William J. Hammond, Michael P. La Quaglia
KHE is a relatively uncommon vascular tumor often associated with KMP. The hallmark features of KMP include an enlarging vascular lesion, microangiopathic hemolytic anemia, thrombocytopenia, and a consumptive coagulopathy that results in a life-threatening hemorrhage.24 KHE may occur in the extremities, cervicofacial, thoracic, or retroperitoneal locations. Retroperitoneal tumors have been found to extend to involve the liver, porta hepatis, pancreas, and mesentery. Mortality may be as high as 60% for those tumors that involve the retroperitoneum.69 In regards to nomenclature, it is generally accepted that tufted angioma and KHE exist on a spectrum and are synonymous tumors.24
Effectiveness of treatment of acquired capillary haemangioma using timolol
Published in Clinical and Experimental Optometry, 2022
Sahil Agrawal, Sujeeth Modaboyina, Mandeep S Bajaj, Saloni Gupta, Deepsekhar Das
An acquired capillary haemangioma can be easily confused with pyogenic granuloma or an acquired tufted angioma of the eyelids.4 Tenderness, hypertrichosis, and induration are useful signs to clinically differentiate tufted angioma from haemangioma. Other differentials include Kaposi sarcoma, eyelid angiosarcomas and varix. Kaposi sarcoma relates closely with the immune status of the patient and is considered as an auto-immune disease syndrome-defining disease by the World Health Organisation.5 The eyelid involvement has a nodular, elevated appearance and precedes in most cases visceral involvement. Cutaneous angiosarcomas of eyelid are very rare and present as purple coloured maculopapular lesions, suggesting a vascular origin in patients over 55 years of age.6 Varix of eyelid has an associated increase in the size of the lesion with strenuous activity like stooping or Valsalva manoeuvre.7
Eruptive cherry angiomas developing in a patient treated with ramucirumab
Published in Acta Oncologica, 2018
Pablo Espinosa Lara, Camino Medina-Puente, Alejandro Riquelme Oliveira, José Jiménez-Reyes
Recently Lim et al. described a patient who had developed a spontaneous proliferative angioma with a somatic activating VEGFR2 mutation in the setting of ramucirumab therapy [2]. Clinical examination showed a single 40 mm, well-demarcated blanchable red plaque on his shin [2]. Histological features resembling a tufted angioma [2]. The authors suggest that vascular lesions may represent paradoxical VEGFR activation in the setting of ramucirumab therapy [2].
Uses of eye drops in dermatology, literature review
Published in Journal of Dermatological Treatment, 2022
Sameh Magdy Sarsik, Heba Saed El-Amawy
Only one recent report of a 5-year-old girl with a painful TA for four years described the efficacy of timolol in treating non-involuting Tufted angioma (TA). For 18 months, she used a topical timolol maleate 0.5% ophthalmic solution followed by four layers of gauze twice daily, with the lesions and pain completely disappeared. There were no side effects and no recurrence for up to 12 months (14).