Sclerema neonatorum

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Published in Biju Vasudevan, Rajesh Verma, Dermatological Emergencies, 2019

Sclerema neonatorum (SN) is a rare condition with grave prognosis seen in premature neonates. It generally occurs in the first week of life and is associated with sepsis and hypothermia. The neonate presents with generalized hardening of the skin. SN was first described by Underwood in the eighteenth century [1]. Histopathological features were described by Ballyntyne [2].

Severe hypercalcaemia and acute renal failure in an infant with subcutaneous fat necrosis

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Published in Paediatrics and International Child Health, 2021

Tülay İnce Becerir, Ayça Altincik, Bayram Özhan, Selçuk Yüksel

SFN is diagnosed clinically. Its differential diagnosis includes deep haemangioma, cellulites, sclerema neonatorum and cold panniculitis [1,9,17]. Cold panniculitis can also be related to exposure, developing within 1–2 days of cold exposure. Skin lesions are confined to areas exposed to the cold [1]. When the definitive diagnosis cannot be made, skin biopsy can be helpful. Cytology demonstrates a granulomatous cellular infiltrate composed of lymphocytes which confirms fat necrosis and crystalline triglyceride in fat cells [4,9,18]. In this case, skin biopsy was undertaken to confirm the diagnosis and the findings supported SFN.