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Skin
Published in Wojciech Gorczyca, Atlas of Differential Diagnosis in Neoplastic Hematopathology, 2014
Lupus erythematosus panniculitis may show features overlapping with SPTL, including dense dermal periadnexal and lobular subcutaneous lymphocytic infiltrate, histiocytic phagocytosis, and fat necrosis. Rimming of adipocytes by lymphocytes is a characteristic of SPTL but may also be seen in lupus panniculitis. The latter shows the rimming composed of not only lymphocytes, but also histiocytes and plasma cells. Lupus panniculitis differs from SPTL by epidermal involvement, mucin deposition, presence of reactive germinal centers, presence of nuclear dust within the inflammatory infiltrate, clusters of B cells, admixture of plasma cells, lack of overt cellular atypia, mixture of CD4+ and CD8+ T cells, and lack of an aberrant loss of one or more of the pan-T-cell antigens [176, 236]. In difficult cases, the presence of clonal TCRγ gene rearrangement help to establish the correct diagnosis of SPTL.
Orbital Mass as the Only Presenting Sign with Overlapping Features of Lupus Erythematosus Panniculitis and Subcutaneous Panniculitis-Like T-Cell Lymphoma
Published in Ocular Immunology and Inflammation, 2023
Mehmet Serhat Mangan, Ahmet Murat Sarici, Ozben Yalcin, Demet Aydin, Gulcin Yegen, Emire Seyahi
Subcutaneous panniculitis-like T-cell lymphoma (SPTCL) is a primary cutaneous lymphoma of T-cell lineage expressing α/β cytotoxic T-cell phenotype.1 Lupus erythematosus panniculitis (LEP) is a rare variant of lupus erythematosus, characterized by chronic inflammation of subcutaneous tissues.2 The clinical and histopathologic distinction of these two separate entities can be challenging as they have significant overlapping features.3–6 Interestingly, Bosisio et al. reported that this overlap of two unrelated pathologies is not coincidental, and they may represent two ends of a single disease spectrum, and they defined a novel disease spectrum.3