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The skin
Published in C. Simon Herrington, Muir's Textbook of Pathology, 2020
Histologically, pilar leiomyomas are composed of interlacing fascicles of bland, blunt-ended spindle cells which lack pleomorphism or mitotic activity (Figure 19.50A,B). Angioleiomyoma, on the other hand, presents as a well circumscribed nodule formed by thick bundles of smooth muscle and collagen with compressed vascular channels.
Tumors of the Uterine Cervix and Endometrium
Published in Victor A. Bernstam, Pocket Guide to GENE LEVEL DIAGNOSTICS in Clinical Practice, 2019
In uterine leiomyomas, the most frequent finding is translocation t(12,14), although the specific gene rearrangement responsible for the tumor are not yet known. In contrast, significant variability exists from case to case in the complex rearrangements observed in the malignant smooth muscle tumor, angioleiomyoma. In yet another type of malignant smooth muscle tumor, rhabdomyosarcoma, the characteristic reciprocal translocation t(2,13) (q37,q14) is found in embryonal, undifferentiated, and alveolar histologic subtypes.
Benign tumors
Published in Archana Singal, Shekhar Neema, Piyush Kumar, Nail Disorders, 2019
Angioleiomyoma of the nail was described more than 130 years ago. More cases were reported,196 of which several were mistaken for glomus tumor because they were painful.197,198 Depending on their localization within the nail apparatus, angioleiomyomas of the nail may elevate the nail plate, appear as a small nodule at the tip of the digit just under the hyponychium or distort the nail.
Rare giant primary intracranial angioleiomyoma in lateral ventricle: a case report and the literature review
Published in British Journal of Neurosurgery, 2020
Jiangwei Ding, Feng Wang, Yuan Li, Tao Sun
A right frontal trans-midline craniotomy was performed. Under the microscope, the tumor tissue was gray-red, tough and with a clear boundary. Microscopic block resection of tumors showed abundant blood supply and severe bleeding was encountered with an operative blood loss of about 1500 ml. Macroscopically, the cut surface was gray-white and soft, and the shape of the cut surface was spongy. Histological examination showed more blood vessels, smooth muscle and collagen tissue (Figure 2). Immunohistochemistry demonstrated that stromal cells were positive for smooth muscle actin (SMA) and calponin and that the endothelial cells positive for CD34 but lacked reactivity to S-100 protein, desmin, and somatostatin receptor-2(SSTR2). The Ki-67 labeling index was 1%. This is consistent with angioleiomyoma.
Pediatric Acral Angioleiomyoma: Report of an Unusual Case and Review of the Literature
Published in Fetal and Pediatric Pathology, 2019
Lucinda Taege, Diane Payton, Geoffrey Strutton
Angioleiomyoma is a benign tumor of middle aged adults, classically presenting as a painful lesion on the limbs [1]. This distinctive clinical presentation of a painful subcutaneous tubercle has been recognized in the medical literature from as early as the eighteenth century, being referred to as “tuberculum dolorosum.” In the nineteenth century, histologic study had shown that some of these painful lesions were comprised primarily of smooth muscle; leiomyoma was not distinguished from angioleiomyoma at this stage. As more cases were identified, it was recognized that there were three distinct histogenic origins for smooth muscle tumors: arrector pili, vessel wall, and smooth muscle at special sites (nipple/genital region) [2]. These categories, first described in a review in 1884, are still recognized today.
A rare case of orbital angioleiomyoma
Published in Orbit, 2021
Shiao Wei Wong, James Laybourne, Luciane Irion, Anne Cook
Angioleiomyoma is a benign smooth muscle tumour composed of vascular and smooth muscle components that usually occurs in the leg.1 It is also known as vascular leiomyoma or haemangioleiomyoma.1,2 Orbital angioleiomyoma is very rare. Currently only one small case series and six case reports exist in the international literature to describe this diagnosis.2–8 Our case of orbital angioleiomyoma in a Caucasian patient is the first to be reported in the English language literature since two case reports from 1965 and 19702,4 We have also provided a summary of all previously published cases in all languages.