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Optimal definition of the limit of detection (LOD) in detecting genetically modified grains from heterogeneous grain lots
Published in Quality Technology & Quantitative Management, 2019
Kohji Yamamura, Junichi Mano, Hiroyuki Shibaike
Then, the number of GM grains (Z) in the subsample is given by a compound distribution (i.e. a stopped-sum distribution by the terminology of Johnson, Kotz, and Kemp [2005]): a negative binomial distribution that is compounded with a Bernoulli distribution of the parameter n2/(n1s). The number of GM grains (Z) in the subsample is alternatively given by a mixture distribution: a mixture binomial distribution where the number of trials (Y) follows a negative binomial distribution. The compound distribution and the mixture distribution yield the same distribution: the negative binomial distribution where the mean is multiplied by n2/(n1s) while the shape parameter is the same.