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Validation Requirements in Biosensors
Published in Sibel A. Ozkan, Bengi Uslu, Mustafa Kemal Sezgintürk, Biosensors, 2023
Leyla Karadurmus, S. Irem Kaya, Goksu Ozcelikay, Mehmet Gumustas, Bengi Uslu, Sibel A. Ozkan
The linearity of the biosensor can be related with the resolution of the biosensor and range of analyte concentrations under testing. The resolution of the biosensor is described as the minimum change in the concentration of an analyte that is needed to bring a changing in the reply of the biosensor. Depending on the application, a good resolution is required as most biosensor applications require not only analyte detection but also measurement of concentrations of analyte over a wide working range (27). Another term associated with linearity is the working range, defined as the range of analyte concentrations at which the biosensor response varies linearly with concentration (31–33). The concentration range should also include the target concentration of the compound to be studied. It should contain at least the expected or required range of analytical results, the latter being directly related to the acceptance limits of the specification or the target test concentration of the analytical procedure style. The working range depends on the analyte, the type of analytical methodology, and the application environment. The range is generally expressed in the same units as the test results obtained by the recommended analytical method (34).
Nanosensors for Industrial Applications
Published in Vinod Kumar Khanna, Nanosensors, 2021
Describe the construction and operation of a percolative Pd nanoparticles array-based pressure sensor. Is it different from a conventional MEMS piezoresistive pressure sensor? If yes, explain the difference? What parameter determines the sensitivity and working range of this sensor? Can the working range be extended?
Statistical Procedure
Published in Morton E. Bader, Practical Quality Management in the Chemical Process Industry, 2020
It is useful to define your working range so that you can be confident 90%, 95% or 99% of the time that all of the values you obtain will fall within calculated limits. Said differently, 10%, 5% or 1% of the time, some values will not fall within calculated limits.
Joining of metal matrix composites using friction stir welding: a review
Published in Materials and Manufacturing Processes, 2019
V. K. Parikh, A. D. Badgujar, N. D. Ghetiya
The flow of plasticized material and the quality and soundness of the weld joint depend on the process parameters. For obtaining a sound weld process, parameters such as speed of the rotating tool, welding speed, shoulder diameter, axial load and geometry of the tool along with angle of tool tilt need to be controlled. The tool geometry includes profile of shoulder, profile of pin, pin length, pin diameter and proportion of shoulder diameter to pin diameter [58,59]. The stirring of material, mixing of material and heat generation depend on rotational speed, whereas the appearance of the welded joint depends on welding speed. The axial load maintains the contact conditions and helps in the generation of frictional heat between the tool and the workpiece. Working range of process parameters is decided based on various pilot experiments. Macrostructures of various pilot experiments are analyzed, and the range of parameters is selected such that the macrostructures are free of defects such as pinhole, tunnel defect, crack, void, surface groove and surface galling.