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The Modulation of IL-6 Levels by Natural Products in Arthritis-Like Animal Models
Published in Parimelazhagan Thangaraj, Lucindo José Quintans Júnior, Nagamony Ponpandian, Nanophytomedicine, 2023
Fabiolla R.S. Passos, Marilia M. Rezende, Sathiyabama R. Gandhi, Bruno A.F. Silva, Andreza G.B. Ramos, Irwin R.A. Menezes, Parimelazhagan Thangaraj, Lucindo José Quintans Júnior, Jullyana S.S. Quintans
Methyl gallate is the primary phenol compound derived from many medicinal plant species. Oral administration of methyl gallate attenuated the experimental arthritis induced by zymosan via the inhibition of several proinflammatory mediators, particularly IL-1β, IL-6 and TNF-α. The molecular analysis of the study showed that methyl gallate inhibited oedema production, leukocyte migration and had a profound influence on signalling cascades related to inflammatory mediators (Correa et al., 2016). Hydroalcoholic extract Schinus terebinthifolius (Brazilian pepper) containing main chemical constituents like gallic acid, methyl gallate and pentagalloylglucose has been traditionally used in the treatment of arthritis, gout, tumours, diarrhoea and respiratory problems in Brazil. Hydroalchoholic extract derived from Brazilian peppers suppressed the secretion of IL-6, IL-1β and TNF-α in synovial tissue of zymosan-induced arthritis (Rosas et al., 2015), therefore showing potential to be further developed as a safe therapeutic agent for treating joint inflammation.
Biotransformations in Deep Eutectic Solvents
Published in Pedro Lozano, Sustainable Catalysis in Ionic Liquids, 2018
Vicente Gotor-Fernández, Caroline Emilie Paul
Similarly, CAL-B has displayed good activities in the transesterification of propyl gallate with methanol to produce methyl gallate (Figure 7.8). Gallic acid alkyl esters present a wide range of biological properties ranging from antitumoral to antioxidant activities, however, their synthesis through lipase-catalyzed esterification of gallic acid in alcohols, organic solvents, or DESs led to no conversion, probably caused by phenolic acid inhibition (Ülger and Takaç 2017). Then, the transesterification process was extensively analyzed using CAL-B as biocatalyst in terms of water content (0%–20%), enzyme concentration (10 g/L–80 g/L), methanol concentration (1–8 equiv.), temperature (35°C–60°C), and agitation speed (75 rpm–250 rpm), finding conversions around 60% after long reaction times under optimal conditions, although with almost negligible formation of gallic acid as hydrolytic by-product.
Antioxidant, cytotoxicity, anti-human esophageal squamous cell carcinoma, anti-human Caucasian esophageal carcinoma, anti-adenocarcinoma of the gastroesophageal junction, and anti-distal esophageal adenocarcinoma properties of gold nanoparticles green synthesized by Rhus coriaria L. fruit aqueous extract
Published in Journal of Experimental Nanoscience, 2020
Jin Liu, Akram Zangeneh, Mohammad Mahdi Zangeneh, Baohu Guo
The requirement of traditional medicine for healthcare is enhanced day by day. One of the well-known traditional medicine in all of the world is Iranian traditional medicine. In Iranian traditional medicine, many sub-traditional medicines are there that the most well-known is Kurdish traditional medicine in the west of Iran. Every year many medicinal supplements and drugs are formulated and produced from the plants of Kurdish traditional medicine [11]. One of these plants is Rhus coriaria L. (Sumac). In traditional medicine, R. coriaria is used for its antibacterial, antifungal, antiviral, anti-parasitic, antioxidant, anti-inflammatory, nephroprotective, hepatoprotective, hematoprotective, hypolipidemic, hypoglycemic, immunoprotective, gastroprotective, DNA-protective, anticancer, and antimigratory activities [18]. It has chemical antioxidant components including dimeric flavonoids amenthoflavone, sumaflavone, hinokiflavone, flavonols quercetin, agathisflavone, kaempferol, myricetin, ellagic acid, methyl gallate, gallic acid, m-digallic acid, β-caryophyllene alcohol, aliphatic aldehydes, α-pinene, farnesyl acetone, cembrene, hexahydrofarnesylacetone, carvacrol, and α-terpineol. Probably, the remedial properties of this species are related to the above compounds [18].
Color integration in biomass-derived carbon dots to realize one-step white light
Published in Green Chemistry Letters and Reviews, 2023
Hui Shi, Chuanqing Li, Xucheng Ke, Yu Cai, Shuangjie Qian, Liuqing Wu, Yuqi Deng, Liman Sai, Xiaofeng Xu
Here, ethanol extract from mango leaves was used as the precursor for CD synthesis. According to the references, phenolic compounds are the major constituents of the mango leaf, including a variety of phenolic acids, phenolic esters, and flavanols (25–28). The representative phenolic compounds in mango leaves are mangiferin, gallic acid, methyl gallate and penta-O-galloyl-glucoside. Some sample compounds are shown in the supporting information for a rough description of their molecular structure (Figure S1).
Solid state fermentation of Bacillus gottheilii M2S2 in laboratory-scale packed bed reactor for tannase production
Published in Preparative Biochemistry and Biotechnology, 2018
Subbalaxmi Selvaraj, Ramachandra Murty Vytla
Five grams of substrate methyl gallate was dissolved in 100 mL citrate buffer of pH 5.0 and 500 mg of lyophilized tannase (partially purified) were added. The reaction mixture was incubated for 24 h at 4 °C for the release of gallic acid upon tannase action on methyl gallate. Later, the reaction mixture was clarified using Whatmann filter paper and was used for 1 H and 13 C NMR analysis (Bruker NMR spectrometer) for the synthesis of gallic acid.[6]