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Analysis of Pesticide Residues by Chromatographic Techniques Coupled with Mass Spectrometry
Published in José L. Tadeo, Analysis of Pesticides in Food and Environmental Samples, 2019
Wan Jing, Jin Maojun, Jae-Han Shim, A.M. Abd El-Aty
Compared with other mass spectrometers, ion traps have a small size, a simple structure, and especially a low price. Therefore, ion traps are common instruments for qualitative analysis that requires the use of a multi-stage mass spectrometric method, and they are widely used in proteomics and the drug metabolism analysis field. For the qualitative analysis of GC–MS, EI ionization can provide abundant structural information and spectral library search. The advantage of ion trap multi-stage mass spectrometric analysis is not prominent. In the quantitative analysis, no matter what the detection limit, linear range, or stability is, the recognized quadrupole mass spectrometer is slightly better than ion trap.
Genotoxicity of quinone: An insight on DNA adducts and its LC-MS-based detection
Published in Critical Reviews in Environmental Science and Technology, 2022
Yue Xiong, Han Yeong Kaw, Lizhong Zhu, Wei Wang
The configuration of ion trap (IT) mass spectrometers includes quadrupole ion traps (QIT) and linear ion traps (LIT) which use dynamic electric fields to trap charged particles (Clarke, 2017). In light of the sensitivity and selectivity, ITs can be performed in multistage MS experiments (MSn) and tandem mass spectrometry, which reflect both the excellent qualitative and quantitative abilities of ITs. Yun et al. utilized LIT in MS3 scan stage to characterize the structure of 7-(deoxyadenosin-N6-yl) aristolactam I in formalin-fixed paraffin embedded (FFPE) kidney and liver tissues with the LOD of 0.15 adducts/108 nucleosides (Yun et al., 2015). Recently, hybrid triple quadrupole-linear ion trap (QTrap) MS system is commonly used for detecting DNA adducts. When fragment ions were produced by CID from Q1 to Q2, they can be trapped within the LIT region and sequentially ejected, producing a full mass spectrum without significant loss of sensitivity (Tang & Zhang, 2020). Wang et al. developed a UHPLC-ESI-QTrap method to detect sulfur mustard-induced N3-HETEA, N7-HETEG and Bis-G in human cell and rat tissues, which achieved the LODs of 0.02, 0.1 and 0.05 ng/mL, respectively. (Wang et al., 2015).