China
Africa
Explore chapters and articles related to this topic
Differential Protein Expression Following JP-8 Jet Fuel Exposure
Published in Mark L. Witten, Errol Zeiger, Glenn D. Ritchie, Jet Fuel Toxicology, 2010
Frank A. Witzmann, Mark L. Witten
The kidney is essential in electrolyte and water balance, acid-base homeostasis, recovery and excretion of compounds, as well as many other physiological functions. Consequently, a very large fraction of the total cardiac output is delivered to the kidney to meet these demands. The kidney also serves as a major route for xenobiotic excretion, particularly of drugs and their metabolites. Like the liver, the kidney is a site for substantial xenobiotic metabolism [44]. For these reasons, the kidney is a prime target for a variety of xenobiotics and a particularly appropriate proteome to explore for the effects of JP-8.
Oxidative stress and adverse cardiovascular effects among professional divers in Egypt
Published in Journal of Occupational and Environmental Hygiene, 2023
Hanie Salah, Ragaa M. El-Gazzar, Ekram W. Abd El-Wahab, Fahmy Charl
In this study, mean serum electrolyte (Ca+, Na+, and K+) levels among the two groups were within normal reference values, although higher levels of Ca+ and lower levels of Na+ were observed in the professional divers compared to the seafarers. A recent study showed that high blood Ca+ levels may increase arterial wall stiffness and subsequently the 10-year CVD risk as assessed by the Framingham score (Park and Lee 2019), which might represent another factor that can lead to increase in the CVD risk. Indeed, hyponatremia may be attributed to repeated physical activity associated with diving and the physical effects of diving, which agree with the findings of Luhker et al. (2017) and Rosner and Kirven (2007) that identified exercise-associated hyponatremia and disturbed acid–base homeostasis after sustained physical exertion during athletic events.
Treatment and high value utilization of glutamic acid wastewater
Published in Preparative Biochemistry & Biotechnology, 2022
Fupeng Yu, Chen Zhao, Le Su, Song Zhang, Xin Sun, Kunlun Li, Qiulin Yue, Lin Zhao
The whole genome of Bacillus licheniformis M 2020051 was sequenced. The whole-genome size was 4,311,767 bp, the GC content percentage was 45.87%, and there were 4480 coding genes, including three kinds of rRNA (5S rRNA, 16S rRNA, 23S rRNA) and 66 tRNA genes. The nhaC gene and the mrp gene were detected from whole-genome sequencing, both of which encode the Na+/H+ antiporter. Na+/H+ antiporter, also known as Na+/H+ pump, is a type of transmembrane protein responsible for ion exchange, and plays a key role in maintaining the normal salt concentration and pH steady state of cells. Among them, mrp is a common gene encoding an antiporter, which is a hetero-oligomeric complex composed of seven subunits. Each subunit is indispensable for the activity of the protein. It exists in high concentrations of Na+ and K+ under the circumstances, the mrp system is essential to maintain the bacterial ion balance and acid-base homeostasis. At the same time, the proH gene was detected, which was related to the synthesis of proline. Proline is a kind of osmotic pressure protection substance, which can relieve the pressure of high salt. This explained why Bacillus licheniformis was resistant to high salt and hypertonicity. At the same time, it was detected that the bacterium contained four genes such as capA, capB, capC, capE and glt gene cluster, which are necessary for the synthesis of polyglutamic acid. It was proved that the polyglutamic acid synthesized by this bacterium is bound to the cell wall and belongs to the binding type.[3,24]