Oral Medication
Valerie L. Stevenson, Louise Jarrett in Spasticity Management, 2016
Tolperisone, a piperidine derivative, is a centrally acting muscle relaxant that is thought to act on voltage-gated sodium and calcium channels. It has been in limited clinical use for spasticity and musculoskeletal conditions such as low back pain since the 1960s,114 although in 2012, the European Medicines Agency restricted its use to post-stroke spasticity due to concerns over hypersensitivity reactions, including anaphylaxis. It is not routinely used in the UK.
Optimisation of methadone treatment in a group of patients on a mephedrone binge and dependent on many psychoactive substances
Published in International Journal of Psychiatry in Clinical Practice, 2020
Michal Ordak, Tadeusz Nasierowski, Elzbieta Muszynska, Magdalena Bujalska-Zadrozny
A statistically significant majority of respondents (n = 375; 62.4%) took methadone, λ2(1) = 36.94; p < .001. Table 2 includes medicines that were most commonly taken with methadone in the studied group. Statistically, the majority of the patients studied received nitrazepam and oxazepam (Table 2) with methadone. The median total number of assigned medications in the group treated with methadone was four. The other most commonly used drugs included hydroxyzine, oxazepam and tolperisone.
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