Histopathologic Classification of Human Sinonasal Tumors
Gerd Reznik, Sherman F. Stinson in Nasal Tumors in Animals and Man, 2017
The adenoid cystic carcinoma may sometimes be predominantly solid, without obvious classic cribriform areas and thus the diagnosis may be difficult. Also, since a mixed tumor can contain areas resembling adenoid cystic carcinoma, this distinction can be difficult. The well-known frequency of histologic nerve invasion by the adenoid cystic carcinoma, while also seen sometimes in other malignancies and thus is not specific for the adenoid cystic category, certainly is a malignant feature which can help make the distinction from benign mixed tumor. In spite of the relatively bland cytologic appearance, the adenoid cystic carcinoma is an egregious malignancy in the sinonasal tract and is virtually impossible to cure in this area. It is usually more rapidly fatal in this area than when it arises in the major salivary glands.
Tracheal resection
Larry R. Kaiser, Sarah K. Thompson, Glyn G. Jamieson in Operative Thoracic Surgery, 2017
The perioperative mortality for surgery in malignant cases, in which more extensive resections are required, is higher, in the region of 5%-6%. It is difficult to give estimates of prognosis after resection of malignancy, as, even in large series, the numbers in subgroups become small. The natural history of adenoid cystic carcinoma is often one of slow progression. Such patients can live for several years after radiotherapy alone, and asphyxia can be prevented by dis- obliteration techniques, stenting, and brachytherapy. In one series, mean survival after treatment of presumably more advanced disease by radiotherapy alone was 6.4 years, com- pared with 9.8 years after complete resection and 7.5 years after incomplete resection and radiotherapy. As in other cancer procedures, the surgeon should strive for complete resection but it is clearly unjustified to imperil the patient by striving for this if wider excision will complicate the recon- struction and add appreciably to perioperative risk. Such a delicately balanced decision requires experience. There are fewer statistics on survival after resection of squamous carcinomas, but survival in the region of 35% at 5 years has been reported.
Tumours of the oral cavity and pharynx
Anju Sahdev, Sarah J. Vinnicombe in Husband & Reznek's Imaging in Oncology, 2020
Distant metastases are a major determinant of prognosis and survival. The reported incidence of distant metastases is between 5% and 17% (69). The lungs are the commonest site involved (70%–85%), followed by bone (15%–39%) and liver (10%–30%) (69). Factors associated with an increased risk include hypopharyngeal location, advanced locoregional stage at presentation (T3/T4, N2c/N3), low jugular or supraclavicular fossa nodal involvement, ENE, and locoregional recurrence (70,71). Pathological risk factors also include unfavourable histology (e.g. adenoid cystic carcinoma), low histological grade, perineural or vascular invasion, and neo-angiogenesis (72).
Adenoid cystic carcinoma of the parotid gland: a first case report on 11C-methionine PET/CT detection of histologically confirmed pulmonary metastases
Published in Acta Oncologica, 2022
Silvia Taralli, Antonella Martino, Alessandra Cancellieri, Lucio Calandriello, Filippo Lococo, Carmelo Caldarella
Adenoid cystic carcinoma (ACC) is a rare head-and-neck malignancy, with a yearly incidence of 3–4.5 cases per million, most commonly observed in middle age women and involving salivary glands. Despite an apparently local indolent course, ACC has an aggressive long-term behavior, presenting with local or distant recurrence even several years after optimal primary tumor treatment, and with a rather poor prognosis (15-years overall survival rate <25%) [1–3]. Distant metastases are observed in more than 50% of cases, even up to 10–20 years after the first diagnosis, being lung the most common site of metastatic involvement. 11C-methionine (11C-MET) positron emission tomography/computed tomography (PET/CT) is considered an effective imaging tool for assessing recurrent ACC, with tracer uptake reflecting increased amino acid metabolism associated with tumor growth [4,5]. However, 11C-MET PET/CT detection of histologically confirmed ACC pulmonary metastases has never been reported before.
The role of frozen section biopsy for submandibular gland tumors
Published in Acta Oto-Laryngologica, 2021
Masahiro Suzuki, Yuta Nakaegawa, Tomotaka Kawase, Masakazu Ikeda, Shigeyuki Murono
Among the 42 patients who had undergone FNAC and FSB, 37, four and one were diagnosed as having benign, indeterminate and malignant tumors, respectively, by FNAC. Of the 37 benign cases, FNAC revealed suspected pleomorphic adenoma (PA) in 24 cases, and could not histologically identify 13 cases. The malignant case detected was suspected to be adenoid cystic carcinoma. Using FSB, 36, three and three cases were diagnosed as benign, indeterminate, and malignant, respectively. Of the 36 benign cases, FSB revealed suspected PA in 34 cases and suspected basal cell adenoma in one case, and could not histologically identify one case. Of the three malignant cases, FSB revealed suspected solitary fibrous tumor in one case, adenocarcinoma in one case, and adenoid cystic carcinoma in one case. The final histological diagnoses showed that 38 cases were benign and four were malignant. All 38 histologically benign cases were PA. The histological tumor types of the four malignant cases included three cases of adenoid cystic carcinoma and one case of carcinoma ex PA (Table 1).
A single-institution review of lacrimal gland biopsies between 1962 and 2017
Published in Orbit, 2023
Catherine J. Choi, Ann Q. Tran, Apostolos G. Anagnostopoulos, Henry W. Zhou, David T. Tse, Sander R. Dubovy
The most common surgical indications listed on the pathology requisition forms included enlarged lacrimal gland with discomfort/pain (110, 27%), rule out lymphoma (100, 25%), rule out pseudotumor (94, 23%), rule out other malignancy (60, 15%), and other (35, 9%). Based on these pre-operative indications listed, 42% of final diagnoses were consistent with the preliminary diagnoses. Of these, the largest groups were lymphoma (55), pseudotumor or NSOI (53), pleomorphic adenoma (13), adenoid cystic carcinoma (8), and metastasis (6). Thirty-seven of the lymphoma cases had evidence of lacrimal gland enlargement on imaging, 10 of which also had concurrent extraocular muscle enlargement. Clinical presentations of these lymphoma patients were largely described as painless eyelid or lacrimal gland swelling with or without proptosis. Thirty-six of the pseudotumor or NSOI patients had evidence of lacrimal gland enlargement on imaging, 16 of which also had concurrent extraocular muscle enlargement. All cases of pleomorphic adenoma presented with a slowly enlarging painless lacrimal gland mass without any involvement of extraocular muscles. Five of the patients with adenoid cystic carcinoma were recurrences with a prior history, and all six cases with metastasis had known primary malignancies at the time of presentation. Exenteration was performed for 8 cases of adenoid cystic carcinoma, 1 carcinoma ex-pleomorphic adenoma, 1 squamous cell carcinoma, and 1 metastatic breast carcinoma.
Related Knowledge Centers
- Cancer
- Salivary Gland
- Breast
- Lacrimal Gland
- Lung
- Brain
- Bartholin'S Gland
- Trachea
- Paranasal Sinuses
- Mucoepidermoid Carcinoma