Physical activity and infectious mononucleosis
Roy J. Shephard in Physical Activity and the Abdominal Viscera, 2017
This chapter presents the clinical problem of how the spleen is affected by infectious mononucleosis and the extent to which physical activity should be restricted during such infections. It considers issues of diagnosis, methods of determining the extent of splenic enlargement and other measures of disease status, and the potential relationship of infectious mononucleosis to chronic fatigue syndrome (CFS), assessing the practical risks associated with engaging in vigorous physical activity at various points in the disease process. Clinical decisions on a return to light, non-contact physical activity and progressive reconditioning are guided by regression of symptoms, normalization of splenic size and epidemiologic data on the likelihood of splenic rupture. Splenic rupture usually occurs during the first three to four weeks of infectious mononucleosis, although one case has been reported seven weeks after onset of the illness, and one recurrence of rupture was seen ten weeks after the first symptoms had developed.
Introduction
Jay A. Goldstein in Chronic Fatigue Syndromes, 2020
Prior concepts and interpretations of chronic fatigue syndrome (CFS) from observations in clinical practice are noted and reviewed, starting with work on the treatment of acute infectious mononucleosis with H-2 blockers. The evolving hypotheses included consideration of the Epstein-Barr virus, cytokine dysregulation, and blocking H-2 receptors on suppressor-cytotoxic T-cells. The rapid effect of selected therapeutic agents on a percentage of patients suggested that in symptom generation neuroimmunoendocrine dysregulation was involved. Early work of Dr. Paul Cheney, Dr. Daniel Peterson, and Dr. John Martin is noted. A CFS symptom checklist is presented, and advances in research leading up to the limbic dysfunction hypothesis are discussed.
The Office Practice of Neurosomatic Medicine
Jay Goldstein in Tuning the Brain, 2004
I began seeing CFS patients when I thought they had chronic mononucleosis, a rather uncommon disorder. They had negative Monospot tests, however. I began to treat them with H2-receptor antagonists, as I had previously done in those with acute infectious mononucleosis, a treatment still not part of mainstream medical care, although I have published its pharmacology in numerous journals and books. This discovery has lain fallow for so many years (since 1980) that I am even tired of complaining about it. H2-receptor antagonists can even treat pseudoseizures, a common neurosomatic problem (Sanne P et al., 1997).
Acute Pancreatitis in Two Cases of Infectious Mononucleosis
Published in Scandinavian Journal of Infectious Diseases, 1976
Sven Åke Hedström, Inger Belfrage
Reports in the literature of acute pancreatitis concomitant with infectious mononucleosis are rare. Two new cases (man, 24, and girl, 12 years) are described. Pancreatitis is of interest mainly in the differential diagnosis versus rupture of the spleen. Abdominal pain in infectious mononucleosis should lead to investigation of amylases in serum and urine.
Heterophil-negative infectious mononucleosis-like syndrome
Published in Postgraduate Medicine, 1987
Michael M. Bergman, Richard A. Gleckman
Preview At first impression, many disorders may seem to have the clinical characteristics of infectious mononucleosis. However, its manifestations are varied, sometimes nonspecific, and can be masked by complicating features, and what are generally considered classic symptoms of the infection are sometimes absent altogether. Adding to the difficulty of diagnosing infectious mononucleosis are the many disorders that mimic it. Drs Bergman and Gleckman compile a sizable assortment of infectious and noninfectious disorders that have signs and symptoms resembling those of infectious mononucleosis. They discuss the most current methods of differential diagnosis and, in convenient tabular form, assemble common risk factors and the latest treatment recommendations.
Splenic infarction as a rare complication of infectious mononucleosis due to Epstein–Barr virus infection in a patient with no significant comorbidity: Case report and review of the literature
Published in Scandinavian Journal of Infectious Diseases, 2013
Eleni Gavriilaki, Nikolaos Sabanis, Eleni Paschou, Savas Grigoriadis, Maria Mainou, Alexandra Gaitanaki, Maria Skargani-Koraka
We report the case of a 17-y-old boy diagnosed with infectious mononucleosis due to Epstein–Barr virus infection who complained of left upper quadrant pain. A magnetic resonance imaging scan showed a splenic infarct in the enlarged spleen. Other causes of splenic infarction were excluded. Thus, infectious mononucleosis may cause splenic infarction in patients without other comorbidities.
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