Introduction
Antonietta Morena Gatti, Stefano Montanari in Advances in Nanopathology From Vaccines to Food, 2021
A biopsy was taken of the liver and of the kidney, and the diagnosis issued by the histopathologist was 'cryptogenic granulomatosis of both organs'. A granulomatosis is a particular inflammatory condition of a tissue. The solution to lachrymation and pain in the ear was easily found in replacing the two dental bridges with as many well-made ones, while fever and problems with the kidneys and the liver were palliated by administering a cortisone-based therapy, a therapeutic strategy which saved the patient from haemodialysis. Many centuries after, man learned how to use that fire, how to cook food, how to fabricate artifacts, so something unknown to nature was introduced into the environment: waste. The models are rather numerous, and their look is quite varied, but the most common is that of six thin metal stems joined at the top of a conical shape like the framework of a tepee.
Drugs that put you to sleep
Peter Nightingale in Anaesthetics for Junior Doctors and Allied Professionals, 2018
This chapter discusses the intravenous induction agents. The 'standard anaesthetic technique' is to induce anaesthesia with a quick-acting intravenous agent. These are mostly short-acting and provide an immediate, deep plane of anaesthesia that will allow control of the airway to take place. The patient must then be kept asleep with either an infusion of intravenous agent or volatile gas. Typically anaesthesia occurs at brain concentration of 4.0–8.0 mcg/mL, with dose adjustments the same as the induction dose. Thiopentone has many drug interactions and is oxidised in the liver. These enzyme systems are quickly saturated, and after multiple doses the metabolism of thiopentone changes from first order to zero order kinetics. Etomidate suppresses the adrenal cortex and cortisone release. For this reason, many anaesthetists no longer use it for septic or shocked patients and those undergoing major surgery. Midazolam is the only one with a short enough duration of action to be realistically used as an induction agent.
Painful Areas of Superficially Eroded Skin in the Flexures of a Child
Rachael Morris-Jones, Ann-Marie Powell, Emma Benton in 100 CASES in Dermatology, 2011
This chapter presents the case study of a 4-year-old girl. A 4-year-old girl is admitted to hospital with painful raw areas in her axillae, neck and groin. These have developed over 24 hours. Her skin had initially become erythematous and inflamed before peeling off to leave large superficial eroded areas in her flexures. This child looked unwell and had tender skin. There was extensive erythema and desquamation in her groin and axillae leading to a diagnosis of staphylococcal scalded skin syndrome (SSSS). Children may be pyrexial and appear unwell; they do not want their skin to be touched at the affected sites owing to tenderness/pain. The patient was admitted to hospital and treated with oral flucloxacillin plus topical combination fusidic acid and hydrocortisone. This child had several episodes of SSSS over a few months. Swabs from family members and close contacts were negative for S. aureus nasal carriage.
Les Insuffisances Surrenaliennes Iatrogenes.
Published in Acta Clinica Belgica, 1958
Summary 1. Hypocorticism occurring after cortisone therapy is extremely frequent, and sometimes longlasting. There is neither clinical nor biochemical sign allowing to detect its latent phase. 2. Every patient having a recent (less than one year) history of intensive cortisone therapy, will not be submitted to surgery without important hormonal therapy. Cortisone treatment should never be stopped nor replaced by ACTH when emergency surgery is planned. 3. Any surgical trauma supervening in a patient having been treated with cortisone will suggest acute adrenal insufficiency, and will be treated by massive administration of cortisone. 4. The weekly interruption of cortisone treatment for one single injection of ACTH does not decrease the incidence of adrenal insufficiency and should accordingly be abandoned. Nevertheless, at the end of cortisone therapy, the administration of decreasing dosage of cortisone along with ACTH during 8 days, and followed by ACTH alone during 3 or 4 days seems to offer effective protection against the impending danger of functional hypocorticism.
Corticosteroids and Carcinogenesis: A Clinical Survey
Published in Acta Rheumatologica Scandinavica, 1959
Summary Animal experiments indicate that cortisone accelerates the growth and dissemination of most tumours. In a number of reported cases the rapid spread of metastases has followed soon after treatment with cortisone. In a patient with carcinoma of the pancreas, cortisone undoubtedly had a deleterious effect. Enquiries should be made to discover if the death rate from cancer in patients taking cortisone is greater than in patients not under such treatment.
Plasma growth hormone concentrations in growth‐retarded, cortisone‐treated chickens
Published in British Poultry Science, 1979
1. Weekly variations in body weight, relative body‐weight gain and plasma growth hormone (GH) concentrations were determined in control and cortisone‐treated (5 mg cortisone acetate/bird d) chickens between 3 and 10 weeks of age. 2. Treatment with cortisone between 3 and 5 weeks of age markedly suppressed growth but did not inhibit GH secretion. 3. After the cortisone injections were stopped these birds grew more rapidly than the controls. However, this period of “catch‐up growth” was not accompanied by alterations in plasma GH concentrations.
Related Knowledge Centers
- Cortisol
- Steroid Hormone
- Transdermal
- Joint
- Adrenal Gland
- Corticosteroid
- Oral Administration