Abies Spectabilis (D. Don) G. Don (Syn. A. Webbiana Lindl.) Family: Coniferae
L.D. Kapoor in Handbook of Ayurvedic Medicinal Plants, 2017
Morphological characteristics — The corms are somewhat conical or broadly ovoid or elongated and planoconvex in section, brownish to brownish gray in color, and are either translucent or opaque. The flat side is longitudinally grooved. The fresh corm is 15 to 35 mm in length and 10 to 20 mm in diameter. Leaves few, lorate, linear oblong or obtuse, appearing with flowers, golden yellow, 1 to 2. The plant flowers soon after the snow melts at higher altitudes.28
Catalog of Herbs
James A. Duke in Handbook of Medicinal Herbs, 2018
Handsome tropical ornamental foliage plant, the foliage sometimes cooked and eaten. Corms, also, are carefully prepared and eaten. Powdered leaves used as an insecticide.56 Ecuadorians place the leaves in the nostrils of their hunting dogs to make them better hunters of wild pigs.111
Effect of carbon monoxide administration using haemoglobin-vesicles on the hippocampal tissue
Published in Artificial Cells, Nanomedicine, and Biotechnology, 2022
Actually, CO is produced in small amounts in the body, where it possesses anti-inflammatory antioxidant capabilities. It has attracted interest as a possible clinically viable medical agent [8–11]. The two main modes of CO administration are intratracheal and intravenous. Intratracheal administration is the inhalation of CO gas, which has been reported as effective for lung diseases, such as chronic obstructive pulmonary disease and pneumonia [12–14], endotoxemia [15], and cardiac hypertrophy [16]. For intravenous administration, CO-releasing molecules (CORM), CO-bound red blood cell (CO-RBC), and CO-bound haemoglobin vesicles (CO-HbV) are experimentally tested. Most CORMs are metal carbonyl complexes with CO bound to them. Various specific triggers initiate the release of CO. For example, CO is released by the effects of esterification, phosphorylation, and photochemical external activation by light of various wavelengths, combinations of thermal degradation and ligand replacement, and replacing ligands [17–21]. Reportedly, CO administration using CORM is effective for treating ischaemia–reperfusion injury of kidney and retinal ganglion cells [22,23], inflammatory bowel disease [24], and non-alcoholic steatohepatitis [25]. CO-RBC is produced by isolating RBC from the blood of donor animals and the succeeding exposure to CO gas. It has been reported that CO-RBC improves microvascular function when administered during resuscitation of haemorrhagic shock [26] and reduces hepatic ischaemia-reperfusion injury [27,28].
Multitargeting approaches involving carbonic anhydrase inhibitors: hybrid drugs against a variety of disorders
Published in Journal of Enzyme Inhibition and Medicinal Chemistry, 2021
Similar to NO discussed in the preceding paragraph, CO is another gaso-transmitter involved in a multitude of physiological processes, although being a highly toxic molecule43. CO, unlike NO, is a rather stable gas and it is endogenously produced through the degradation haem under the action of the enzyme haem oxygenases (HO; EC 1.14.99.3), more precisely its isoforms HO1 and HO244. These enzymes and the CO produced through their activity, play a protective role against intracellular oxidative stress, and an overexpression of HO1 was reported in several inflammatory and autoimmune diseases45. Thus, although CO is highly poisonous compound due to its strong affinity for haemoglobin (Hb), this gas also binds to other haem-containing proteins, such as the soluble guanylyl cyclase (sGC), the NO synthase (NOS), the NADPH oxidase as well as mitochondrial cytochrome C oxidase, and this probably endows CO with cytoprotective and homeostatic antiiflammatory properties46. Indeed, in the last decades, CO releasing molecules (CORMs) which allow a controlled release of small amounts of this toxic compound started to be considered for therapeutic applications46,47. The alkyne hexacarbonyl dicobalt(II) complexes are the most well-known CORMs, although many other such chemotypes have been developed46,47.
Carbon monoxide-releasing molecule-401, a water-soluble manganese-based metal carbonyl, suppresses Prevotella intermedia lipopolysaccharide-induced production of nitric oxide in murine macrophages
Published in Immunopharmacology and Immunotoxicology, 2023
Eun-Young Choi, Jung Eun Lee, Ah Rim Lee, In Soon Choi, Sung-Jo Kim
Recently, a series of CO-releasing molecules (CORMs) possessing different chemical properties have been developed for the delivery of exogenous CO to biological systems in a controlled manner [30]. Many reports in the literature have suggested the therapeutic value of CORMs against various disorders [31–33]. However, to date, little is known about their possible influence on periodontal disease. CORM-401 is a water-soluble manganese-based metal carbonyl that is not only more potent than previously characterized CORMs but also a slow CO releaser [34]. This study was performed to investigate the influence of CORM-401 on the generation of NO in murine macrophage cells activated with LPS derived from P. intermedia and its possible mechanisms.
Related Knowledge Centers
- Carbon Monoxide
- Carbon Monoxide Poisoning
- Combustion
- Heme Oxygenase
- Gasotransmitter
- Anti-Inflammatory
- Thermal Decomposition
- Water Gas
- Nickel Tetracarbonyl
- Metal Carbonyl