Treatment Options: III. In Vitro Fertilization
Steven R. Bayer, Michael M. Alper, Alan S. Penzias in The Boston IVF Handbook of Infertility, 2017
This treatment involves the first two steps of IVF treatment: ovarian hyperstimulation and egg retrieval. In contrast to IVF, the gamete intrafallopian transfer (GIFT) procedure involves a laparoscopy to place eggs and sperm into the fallopian tube, allowing the tube to be the natural incubator. Usually, four to six eggs are replaced. The disadvantage of the GIFT procedure is that a laparoscopy has to be performed under general anesthesia. A prerequisite to performing the GIFT procedure is that the woman must have at least one normal fallopian tube. This procedure was quite popular in the 1980s but is rarely performed nowadays because of the high success rates with IVF. Actually less than 1% of assisted reproductive technology (ART) procedures are GIFT. Indications for resorting to GIFT include altered cervical anatomy that prevents a successful uterine transfer, or if religious reasons preclude IVF.
Reproductive technology
Frank J. Dye in Human Life Before Birth, 2019
Embryo transfer after IVF does not always result in the successful implantation of the embryo into the woman's uterus. One technique to increase the chances of implantation is to bring together the parents’ gametes in the fallopian tubes. Gamete intrafallopian transfer (GIFT) begins with gathering of sperm and eggs, as if in preparation for IVF. Next, first the eggs and then the sperm are loaded into a catheter (a hollow tube), which is used to transfer the gametes into the fallopian tubes. In GIFT, fertilization occurs more naturally than with IVF, and the embryo formed subsequently enters the uterus by the normal route (Figure 21.2).
Female infertility
David M. Luesley, Mark D. Kilby in Obstetrics & Gynaecology, 2016
Gamete intrafallopian transfer (GIFT) used to be the treatment of choice for patients with unexplained infertility. However, IVF-ET, with its diagnostic potential, has superseded this modality. Although GIFT offered a high pregnancy rate, the ectopic pregnancy risk was also high [C], and the treatment requires general anaesthesia and laparoscopy in order for gametes to be placed within the ampulla of the Fallopian tube. This method has largely been supplanted by IVF-ET.
The impact of emotional health on assisted reproductive technology outcomes: a systematic review and meta-analysis
Published in Human Fertility, 2022
Grace Peaston, Venkatesh Subramanian, Oliver Brunckhorst, Ippokratis Sarris, Kamran Ahmed
Original data on men, women or couples in ART treatment were included. ART was defined as extracorporeal handling of gametes or embryos to induce pregnancy. This includes IVF, intracytoplasmic sperm injection, zygote intrafallopian transfer and gamete intrafallopian transfer but excludes intrauterine insemination. Procedures involving donor materials were excluded to avoid confounding due to the mental state of the donor. Studies must have measured pre-treatment emotional health through validated psychometric scales. Pre-treatment measurement avoided confounding stress from hormonal treatment or feedback on progress. Studies must have reported primary or secondary outcomes (see data items). Clinical pregnancy was defined as ultrasound-confirmed pregnancy, and chemical pregnancy as pregnancy detected through human chorionic gonadotropin measurement. Interventional studies were excluded to avoid confounding effects of treatments. Reviews, animal studies and non-English language papers were excluded.
Assisted reproductive technology outcome in United States of America and Australia with New Zealand: comparison of annual reports 2005–2016
Published in Gynecological Endocrinology, 2020
Blazej Meczekalski, Anna Szeliga, Agnieszka Podfigurna, Izabela Miechowicz, Eli Y. Adashi
Each report includes success rates for the three categories of ART cycles: cycles using fresh embryos from nondonor eggs, cycles using frozen embryos from nondonor eggs, and cycles using donor eggs. Success rates shown are calculated on the basis of data from all ART cycle procedures (IVF, gamete intrafallopian transfer or GIFT, and zygote intrafallopian transfer or ZIFT).
Related Knowledge Centers
- Assisted Reproductive Technology
- Chorionic Gonadotropin
- Infertility
- Laparoscopy
- Ovary
- In Vitro Fertilisation
- Fallopian Tube
- Zygote Intrafallopian Transfer