Miscellaneous
Joseph Kovi, Hung Dinh Duong in Frozen Section In Surgical Pathology: An Atlas, 2019
This chapter discusses medical conditions where a definite diagnosis was made from frozen section diagnosis. It includes a case of a 67-year-old man was admitted to the hospital because of fever, malaise, cough, and severe pleuritic pain. Rectal digital examination revealed a hard nodule in the prostate. Patients suffering from chronic fibrosing pancreatitis, are usually 35 to 45 years old, are chronic alcoholics, and have a history of repeated attacks of acute pancreatitis. In frozen sections some of the atrophic acini simulate infiltrating glands and cords of an adenocarcinoma with productive fibrosis. Greatest care must be exercised in rendering the pathologic diagnosis. In most of the patients suffering from tumors of the major salivary glands, approximately one third percent of all malignant tumors develop in the salivary glands. About 60% of the neoplastic lesions occur in the parotid gland. Frozen section examination is the appropriate diagnostic method in the management of parotid and submaxillary tumors.
Arthritis
Harry Griffiths in Musculoskeletal Radiology, 2008
A traditional approach to arthritis would probably start with the most common types of disease and then go on to describe the rarer ones. Degenerative arthritis, or osteoarthritis, is the most common form of hypertrophic arthritis seen mainly in large, weight-bearing joints in older patients. The superior aspect of the hip joint is the weight-bearing surface; hence, pure degenerative arthritis manifests itself clinically by narrowing of the superior part of the joint with sclerosis, osteophyte formation, and lateral migration of the femoral head. Most of the erosive arthritides such as juvenile chronic arthritis, rheumatoid arthritis, and ankylosing spondylitis cause central destruction of the joint cartilage in the hip. Degenerative arthritis in the small bones of the foot can be seen as a result of mechanical problems in the foot, such as pes planus, pes cavus, and metatarsus varus. Rheumatoid arthritis has an insidious onset and starts with fatigue and malaise, and the patient will complain of diffuse musculoskeletal pain.
How Do You Know If Your Child Has CFIDS
David S. Bell, Mary Robinson, Jean Pollard, Thomas A Robinson, Bonnie Floyd in A Parents' Guide to CFIDS, 1999
The fatigue of chronic fatigue immune dysfunction syndrome (CFIDS), however, is an exhaustion that is combined with malaise or a flulike feeling, weakness, and a sensation of impending total collapse. CFIDS pain can be felt in most areas of the body: muscles, joints, throat, lymph nodes, stomach, and head. The muscle pain is a general aching in the large muscles in the legs, arms, back, and sometimes the chest. The most dominant neurological problems that young persons with CFIDS (YPWCs) experience, which affect them the most in school, are the cognitive problems associated with CFIDS, including short-term memory loss, forgetfulness, and a short attention span. Much more attention has been given to adults with CFIDS than to the children who suffer. Although CFIDS can have the same effect on both adults and children, children often react to its symptoms differently. The parent of a child with CFIDS is so often the child's advocate with doctors.
Clinical and biochemical characteristics of patients having general symptoms with increased serum IgG4
Published in Modern Rheumatology, 2020
Kou Hasegawa, Yoshihisa Hanayama, Mikako Obika, Tomoko Miyoshi, Hiroko Ogawa, Eisei Kondo, Hitomi Kataoka, Yasuharu Sato, Fumio Otsuka
Objective: To differentiate patients with IgG4-related diseases (RD) from patients with other hyper IgG4 conditions who visit general medicine department. Methods: Fifty-six patients with high serum IgG4 levels (>135 mg/dL) were classified into three groups based on the final diagnosis: definite and possible IgG4-RD and others. Clinical and laboratory characteristics of the three groups of patients were retrospectively analyzed. Results: Major manifestations were renal dysfunction and general malaise, while thirst was the most frequent symptom in the definite group, in which submandibular glands and lymph nodes were likely to be affected. Biopsy of minor salivary glands was the least diagnostic for IgG4-RD despite the high frequency of biopsy. In the definite group, serum levels of IgG4 and IgG, IgG4/IgG ratio and basophil number were increased, while serum levels of CRP, IgA and complements were decreased. A negative correlation between serum levels of IgG4 and IgM was found in the definite group. Conclusion: The results indicated that in patients with renal dysfunction, malaise, thirst or weight loss, measurements of the levels of basophils, immunoglobulins and complements are helpful for diagnosing IgG4-RD. Considering distribution of affected tissues and localization of diagnostic biopsies, physical examination and laboratory workup are required for early diagnosis.
Chronic fatigue syndrome and myalgic encephalomyelitis: towards an empirical case definition
Published in Health Psychology and Behavioral Medicine, 2015
Leonard A. Jason, Bobby Kot, Madison Sunnquist, Abigail Brown, Meredyth Evans, Rachel Jantke, Yolonda Williams, Jacob Furst, Suzanne D. Vernon
Current case definitions of myalgic encephalomyelitis and chronic fatigue syndrome (CFS) have been based on consensus methods, but empirical methods could be used to identify core symptoms and thereby improve the reliability. In the present study, several methods (i.e. continuous scores of symptoms, theoretically and empirically derived cut off scores of symptoms) were used to identify core symptoms best differentiating patients from controls. In addition, data mining with decision trees was conducted. Our study found a small number of core symptoms that have good sensitivity and specificity, and these included fatigue, post-exertional malaise, a neurocognitive symptom, and unrefreshing sleep. Outcomes from these analyses suggest that using empirically selected symptoms can help guide the creation of a more reliable case definition.
Necrotizing ulcerative gingivitis and the orthodontic patient: A case series
Published in Journal of Orthodontics, 2013
Indiya Sangani, Eileen Watt, David Cross
Necrotizing ulcerative gingivitis (NUG) can be a painful periodontal disease that can lead to loss of the interdental papillae. It is usually accompanied by systemic signs of fever, malaise and cervical and submandibular lymphadenopathy. It is caused by the profileration of anaerobic bacteria and has been linked to smoking and immunosuppression. This case series reports the occurrence of NUG in orthodontic patients and demonstrates that there is a varying scale of severity of the condition. Orthodontists should be aware of the clinical signs of NUG to ensure early detection and treatment of their patients in order to prevent irreversible loss of the interdental papillae and reduce the likelihood of recurrence. A treatment regime is suggested.
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