Osteoimmunology in Aging
Shamim I. Ahmad in Aging: Exploring a Complex Phenomenon, 2017
An unexpected relationship between bone and immune cells has recently emerged, resulting in the establishment of osteoimmunology, an innovative discipline that investigates interactions between the skeleton and immune system, the so-called immunoskeletal interface. Recent discoveries in this research field highlighted a new landscape of osteoporosis, and enabled the development of innovative therapies for its treatment. From this perspective, osteoporosis could be regarded as an age-related chronic immune-mediated disease, sharing with other age-related disorders a common inflammatory background [1].
Osteocalcin and regulatory cytokine imbalance in children with congenital cleft lip and palate
Published in Immunological Medicine, 2020
Irina Nesterova, Marina Mitropanova, Galina Chudilova, Lyudmila Lomtatidze
Over the past decade, a new scientific direction, osteoimmunology, has been actively developed [11]. Osteoimmunology is an interdiscipline that focuses on the relationship between the skeletal and immune systems. In 2000, Arron J. and Choi Y. first proposed the term ‘osteoimmunology’ [12]. Over the past 20 years, evidence has accumulated demonstrating that the skeletal system is involved in the processes of hematopoiesis and affects the state of the immune system. At the same time, numerous cells of the immune system and the cytokines produced by them are involved in bone homeostasis. Complex interactions between the bone and immune systems occur in various diseases, such as osteoporosis, rheumatoid arthritis, ankylosing spondylitis, HIV infection, Crohn’s disease, systemic lupus erythematosus [13–16]. Cells of the immune system regulate bone cells using various cytokines and molecules. It is known that IL1β, IL6, IL17, TNFα, TNFβ, RANKL and M-CSF promote osteoclastogenesis. Molecules IL23, IL6, IL12, IL18, IL4, IFNγ and TGFβ inhibit osteoclastogenesis, IL17A and BMP-2 stimulate the formation of osteoblasts [11].
The role of imaging in early diagnosis and prevention of joint damage in inflammatory arthritis
Published in Expert Review of Clinical Immunology, 2018
Jiang Yue, Dongze Wu, Lai-Shan Tam
Bone homeostasis, which involves osteoblast and osteoclast, is an important process for maintaining adequate bone mass in humans. Inflammatory burden and autoantibody positivity have both been identified as important initiators of skeletal damage in arthritis. Osteoimmunology is important in helping us understand the interaction between the skeletal and the immune systems. Unraveling the cellular and molecular mechanisms elicited by synovial cytokine networks that dictate recruitment, differentiation, and activation of osteoclast precursors and osteoclasts, respectively, is central to shaping novel therapeutic options for inflammatory arthritis patients. With the availability of various imaging modalities including US, MRI, and HR-pQCT, these powerful tools are becoming more important to assist clinicians in early detection of inflammation and joint destruction. Nonetheless, the clinical utility of these imaging tools to improve diagnostic accuracy and guiding therapeutic decision-making is still unclear.
The osteoimmunomodulatory properties of MBG scaffold coated with amino functional groups
Published in Artificial Cells, Nanomedicine, and Biotechnology, 2018
Deliang Zeng, Xingdi Zhang, Xiao Wang, Qingfeng Huang, Jin Wen, Xinchao Miao, Lingjie Peng, Yongsheng Li, Xinquan Jiang
In the present study, the formation of new bone was supported and promoted by the amino functionalized MBG scaffolds in the maxillary sinus floor. Macrophages, located around the bone biomaterials, play pivotal roles in osteoimmunology [35]. The host immune response might be immediately triggered by the implanted scaffolds based on the macrophages infiltration. Macrophages can commit to two distinct phenotypes under different microenvironments in a process termed “polarization” (classically activated and inflammatory (M1) and alternatively activated and predominantly anti-inflammatory (M2) macrophages) [36,37]. The transition between these states is decided by the local cytokine milieu. M2 macrophages could be induced by cytokines such as IL-10 and arginase-1 [24,25]. Figure 3 shows that Arg-1 expression on day 4 and IL-10 and Arg-1 expression on day 7 significantly were enhanced when BMSCs seeding onto the amino functionalized MBG scaffold compared with the seeding of cells onto the MBG scaffold. However, there were no significant differences in IL-1β cytokine production among these groups (Figure 3(c)). Thus, when BMSCs are seeded onto the amino functionalized MBG scaffold, an increase in the M2 cytokines (IL-10 and Arg-1) may enable infiltrating macrophages to differentiate into M2 macrophages, which were conducive to tissue repair.
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