Microdeletion Syndromes
Merlin G. Butler, F. John Meaney in Genetics of Developmental Disabilities, 2019
A few genes of interest have been localized to chromosome 5p. Two genes that have been mapped to the cri du chat region and could possibly play a role in cognition are the semaphorin F gene that has a role in neuronal migration during development and the δ-catenin gene (CTNND2) that codes a neuronal-specific protein involved in cell motility (37,38). The telomerase reverse transcriptase (hTERT) gene that is located at 5p15.33 was also shown to be insufficient for maintaining telomere length in cri du chat patients and may contribute to the phenotype (39).
δ-Catenin peptide vaccines repress hepatocellular carcinoma growth via CD8+ T cell activation
Published in OncoImmunology, 2018
Fei Huang, Junying Chen, Ruilong Lan, Zeng Wang, Ruiqing Chen, Jingan Lin, Lurong Zhang, Lengxi Fu
Tumor vaccines can trigger anti-tumor immune response with minimal toxicity.3,5,35 Tumor vaccines immunization is one of active immunotherapy methods. Active immunotherapy is safe and cost-effective, compared with antibody drugs.5,36 However, tumor vaccines cannot be widely applied for clinical therapy due to its limited effects. Nowadays, researches for tumor vaccines are focused on developing personalized vaccines and finding neo-antigens as targets.37 δ-Catenin has been reported to be a potential biomarker and therapy target for various cancers.15 We find it may be also a neo-TAA for HCC. However, drugs or antibodies targeting δ-Catenin have not yet been developed. We firstly report the anti-tumor functions of peptide vaccines targeting δ-Catenin, which may be an economical and effective way to target δ-Catenin for HCC therapy.
14-3-3 proteins at the crossroads of neurodevelopment and schizophrenia
Published in The World Journal of Biological Psychiatry, 2022
André S. L. M. Antunes, Verônica M. Saia-Cereda, Fernanda Crunfli, Daniel Martins-de-Souza
During early neurodevelopment, radial glial cells (RGCs), which are precursors of glial and neuronal cells, are in a tightly regulated balance between symmetric and asymmetric cell division and this is key for neuron generation, proliferation and differentiation in the cortex (Pontious et al. 2008). This balance is also maintained by 14-3-3 proteins as evidenced by brain malformations in 14-3-3 deficient models (Toyo-Oka et al. 2014) (these will be discussed later in this review). For instance, the isoforms ε and ζ have been shown to bind to and affect the stability of δ-catenin, which is a member of the catenin family and is involved in the regulation of cell-to-cell adhesion; downstream effects include increased neurogenesis and neuronal differentiation via regulation of F-actin formation (Toyo-Oka et al. 2014).
Interplay between EGFR, E-cadherin, and PTP1B in epidermal homeostasis
Published in Tissue Barriers, 2023
Tessa Arnaud, Fernando Rodrigues-Lima, Mireille Viguier, Frédérique Deshayes
The crosstalk between both molecules has firstly been described through interactions via intracellular partners belonging to the AJ complex. As early as the 1990s, it was demonstrated using recombinant proteins that beta-catenin directly interacts with EGFR. This interaction seems to be mediated by the central region of beta-catenin. This region having about 80% identity at the amino acid level with plakoglobin and armadillo protein suggests possible interactions of EGFR with these molecules.42 More recently, it has been shown that EGFR also interacts with another catenin of the AJ complex: δ-catenin. This direct interaction has been demonstrated in bosc23 (human kidney cell line) and CWR22Rv-1 cells (Human Prostate cancer cell line) cells. Moreover, the authors noted that this interaction was decreased in the presence of EGF without affecting the localization of δ-catenin.
Related Knowledge Centers
- Cadherin
- Catenin
- Palmitoylation
- Wnt Signaling Pathway
- P120 Catenin
- Catenin Beta-1
- Plakoglobin
- Presenilin
- NF-Κb