Nanotechnology and Delivery System for Bioactive Antibiofilm Dental Materials
Mary Anne S. Melo in Designing Bioactive Polymeric Materials for Restorative Dentistry, 2020
Although employed widely in the remineralization of carious dentin, such an ion-based strategy cannot be effective in locations where the crystallites are totally destroyed (Frencken et al. 2012). Another promising class of mineralization materials is the biomineralization agents. Inspired from the function of noncollagenous proteins (NCPs) in the biomineralization process of natural teeth, using biomimetic templates to remineralize the demineralized dentin is of great interest in the recent years as NCPs, the natural nucleation templates, lose their abilities to induce in situ remineralization in the mature dentin (Chen, Liang et al. 2013). Poly(amino amine) (PAMAM)-type dendrimer is widely studied in dental biomineralization. It is a class of monodispersed polymeric nanomaterials with plenty of branches radiating from one central core and highly ordered architecture. It has been referred to as “artificial protein” due to its biomimetic properties and well-defined/easily tailored structure, such as its functional group, generation, and spatial structure. Previous studies have clearly demonstrated that PAMAM and its derivatives could induce biomineralization of demineralized dentin (Chen, Liang et al. 2013, Wu et al. 2013). PAMAM combined with antibacterial agents also obtained double effects of mineralization, and antibacterial and needlelike crystals can precipitate both on the dentin surface and in the dentinal tubules (Lei Cheng et al. 2016).
Evaluation of PCL/Chitosan/Nanohydroxyapatite/Tetracycline Composite Scaffolds for Bone Tissue Engineering
Naznin Sultana, Sanchita Bandyopadhyay-Ghosh, Chin Fhong Soon in Tissue Engineering Strategies for Organ Regeneration, 2020
The osteogenic potential of the composites can be evaluated by submerging the scaffolds in simulated body fluid (SBF) to form the apatite layer (Marc and Jacques 2009). This method has become the “gold standard” to ascertain whether materials are bioactive or not since the invention of SBF by Kokubo et al. in 2003 (Wu et al. 2014). The ion concentration of SBF is the same as in human blood plasma, which is suitable for the in vitro study of the biomineralization of scaffolds. Bioactivity of the scaffolds is said to be a performance indicator for the biomaterial for biomineralization in an in vitro and in vivo study. Biomineralization is a process for the deposition or growth of bone-minerals, like crystals such as hydroxyapatite, apatite and CaP compounds on the scaffolds. In the matrix of organisms, biomineralization induces the formation of the bone mineral-like skeletal structure during development (Wu et al. 2014).
Molecular Biology of the Amelogenin Gene
Colin Robinson, Jennifer Kirkham, Roger Shore in Dental Enamel, 2017
When living cells or tissues control the deposition of mineral, either intracellularly or extracellularly, the process is termed biomineralization. Living cells maintain control over this complex process by precisely regulating the transcription of specific genes that encode proteins that contribute to the biomineralization process. These genes may encode (a) structural proteins required for the assembly or disassembly of a protein matrix during mineral deposition and (b) proteins that are responsible for the sequestration and/or transport of ions that contribute to the mineral phase. While biomineralization occurs in many diverse phyla and tissues, this review focuses attention on a unique mammalian tissue, enamel.
Influence of infrastructure material composition and microtopography on marine biofilm growth and photobiology
Published in Biofouling, 2021
Baptiste Vivier, Pascal Claquin, Christophe Lelong, Quentin Lesage, Mathias Peccate, Bastien Hamel, Marine Georges, Amel Bourguiba, Nassim Sebaibi, Mohamed Boutouil, Didier Goux, Jean-Claude Dauvin, Francis Orvain
A total of 50 MI samples were constructed. The MI were shaped like a cobble (5 cm×5 cm×3 cm; L××h) and for this study, four concrete formulations were designed with two types of cement, Portland cement, CEM I/A-LL 42.5 R CE PM-CP2 NF and CEM II/A (S-V) 32.5 N-LH CE PM-ES-CP1 NF as these two types of cement are suitable for use in seawater. Granular class 0/2 mm siliceous alluvial sand was used. Alluvial aggregates of two sizes, 4/10 mm and 10/20 mm, were also used. Twenty percent of the aggregates (4/10 mm) were replaced by oyster shell aggregates to study the effect of this biomineral by-product on the recruitment of oyster larvae. It has been shown that the incorporation of mollusc shell aggregates (6/12.5 mm) could increase the bio-receptivity of concrete because they provide an ideal substratum for the settlement of marine organisms (Graham et al. 2017; Hanlon et al. 2018). Six control samples were made of PVC, as this type of support is suitable and is generally used for oyster larval catchers in shellfish aquaculture.
Facile green synthesis of bismuth sulfide radiosensitizer via biomineralization of albumin natural molecule for chemoradiation therapy aim
Published in Artificial Cells, Nanomedicine, and Biotechnology, 2019
Hamed Nosrati, Fatemeh Abhari, Jalil Charmi, Mohammad Rahmati, Behrooz Johari, Sedigheh Azizi, Hamed Rezaeejam, Hossein Danafar
In conclusion, a biodegradable and stealthy nanostructure has been successfully developed through BSA-mediated biomineralization method for drug delivery in living cell. In the present synthetic method, BSA has two practical roles. The BSA not only worked as a stabilizer but also as a sulfur precursor for forming Bi2S3 HNPs with excellent colloidal stability. Also, Bi2S3@BSA@CUR HNPs exhibited attractive controlled release ability for CUR. This Bi2S3@BSA@CUR HNPs represents an essential approach for efficiently cancer therapy. In vitro cytotoxicity assay was performed to compare anti-tumour effects of Bi2S3@BSA@CUR HNPs and free CUR with and without of irradiation. The result of this study proved that Bi2S3@BSA@CUR with the aid of X-Ray irradiation increased therapeutic efficacy and can be used as a proficient vehicle for effective delivery of CUR in treatment of cancer. Compared to control group the presence of both X-ray irradiation and Bi2S3@BSA@CUR HNPs showed 40%, 47% and 57% increased of cytotoxicity towards HT-29 cells at 25 µg/ml, 50 µg/ml and 100 µg/ml concentration, respectively.
Albumin-bioinspired iridium oxide nanoplatform with high photothermal conversion efficiency for synergistic chemo-photothermal of osteosarcoma
Published in Drug Delivery, 2019
Wenguang Gu, Tao Zhang, Junsheng Gao, Yi Wang, Dejian Li, Ziwen Zhao, Bo Jiang, Zhiwei Dong, Hui Liu
In conclusion, we have successfully developed a biocompatible nanoplatform based on BSA-IrO2 NPs for stimuli-responsive drug delivery and synergistic chemo-photothermal therapy. The BSA-IrO2 NPs was prepared through a simple biomineralization method. The as-prepared BSA-IrO2 NPs exhibit superb biocompatibility and excellent photothermal conversion capability upon NIR irradiation. The NPs can also be served as carrier for loading of small molecular drugs. Using DOX as a model drug, the BSA-IrO2 also showed considerable drug loading capacity, and the drug release could be triggered by NIR laser and acidic pH. Importantly, highly effective synergetic antitumor efficacy of the BSA-IrO2@DOX has been demonstrated both in vitro and in vivo, which is superior to that of either monotherapy alone. Further, in vivo experiments showed that BSA-IrO2@DOX had long blood circulation time and efficient tumor accumulation. Thus, such BSA-IrO2@DOX nanoparticles present great potential as a nanoplatform for the development of more efficient antitumor treatments. This work has focused on the direction of iridium-based nanomaterials for cancer therapy. Considering that this is the first time to employ the BSA-IrO2 nanoparticles as drug carrier, the protein-based nanocarriers strategy in this work shows general potential for the fabrication of other drug delivery systems.
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