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Kearns-Sayre Syndrome
Published in Shamim I. Ahmad, Handbook of Mitochondrial Dysfunction, 2019
Blood tests usually show elevation of serum lactate and pyruvate (van Beynum et al., 2012). In some patients aminoacids, such as alanine, may be elevated (van Beynum et al., 2012). Occasionally, fasting blood glucose, oral glucose tolerance test, or the HbA1c values may be elevated. Serum aldosterone levels may be elevated in case of hyperaldosteronism (Park et al., 2004). In case of hypothyroidism, thyroid function parameters may be abnormal. In some patients deficiency of ubidecarenone or coenzyme-Q in the serum can be found (Park et al., 2004).
Effect of coenzyme Q10 on the malondialdehyde level and exercise performance of male runners in Jakarta
Published in Elida Zairina, Junaidi Khotib, Chrismawan Ardianto, Syed Azhar Syed Sulaiman, Charles D. Sands, Timothy E. Welty, Unity in Diversity and the Standardisation of Clinical Pharmacy Services, 2017
S. Gunawan, Purwantyastuti, F.D. Suyatna, E.I. Ilyas
In addressing the negative impact on exercise-induced-oxidative stress, many studies were conducted to examine the benefits of antioxidant supplementation (Urso & Clarkson, 2003, Powers et al. 2004, Williams et al. 2006). One of them is Coenzyme Q10 (CoQ10), also known as ubiquinone or ubidecarenone. CoQ10 is a vitamin-like, fat-soluble substance present in cells. It plays an important role in transferring electrons within the mitochondrial oxidative respiratory chain and promoting ATP production, also acting as an essential antioxidant (Crane 2001).
Nutritional Ergogenic Aids: Introduction, Definitions and Regulatory Issues
Published in Ira Wolinsky, Judy A. Driskell, Nutritional Ergogenic Aids, 2004
Ira Wolinsky, Judy A. Driskell
Coenzyme Q10 (CoQ10), also known as ubiquinone or ubidecarenone, is a vitamin-like, lipid-soluble compound existing in all cells. It was initially isolated from animal tissues in the mid-1950s and found to be capable of undergoing reversible oxidation and reduction.1-3 This property is the key to the crucial roles of CoQ10 in the body, as a redox electron carrier in the mitochondria that is coupled to energy transfer and as an essential anti-oxidant.4,5 It is also known that CoQ10 is involved in several other cellular functions— assisting in regeneration of other antioxidants, influencing stability, fluidity and permeability of membranes, stimulating cell growth and inhibiting cell death.4,6 Approximately one half of CoQ10 is found in the
Effect of coenzyme Q10 supplementation on clinical features of migraine: a systematic review and dose–response meta-analysis of randomized controlled trials
Published in Nutritional Neuroscience, 2020
Mohammad Parohan, Payam Sarraf, Mohammad Hassan Javanbakht, Sakineh Ranji-Burachaloo, Mahmoud Djalali
We systematically searched online medical databases including ISI Web of Science, PubMed, Cochrane library and Scopus to identify eligible studies published in English up to April 2018. The following search keywords were used: (‘Migraine Disorders’ OR Migraine* OR Headache OR Migraineur*) AND (‘coenzyme Q10’ OR ‘ubiquinol-10’ OR ‘Coenzyme Q10 Deficiency’ OR ‘co-enzyme Q10’ OR ubiquinone OR ubidecarenone OR CoQ10 OR semiquinone OR ubisemiquinone OR ubiquinol). The reference lists of eligible articles also were checked. All search results including titles and abstracts were downloaded into EndNote (version X8) to merge retrieved citations, remove duplicated, and simplify the review process.
Improved photostability and cytotoxic effect of coenzyme Q10 by its association with vitamin E acetate in polymeric nanocapsules
Published in Pharmaceutical Development and Technology, 2018
Natháli S. Pegoraro, Juliane Mattiazzi, Elita F. da Silveira, Juliana H. Azambuja, Elizandra Braganhol, Letícia Cruz
Coenzyme Q10, also known as ubiquinone or ubidecarenone (2,3-dimethoxy-5-methyl-6-decaprenyl-1,4-benzoquinone) (Q10), is a lipophilic molecule that presents important antioxidant activity by scavenging free radicals and inhibiting lipid peroxidation (Ernster & Dallner 1995; Aberg et al. 1998; Bhagavan et al. 2007). Q10 molecule is synthesized in the human body through mevalonate pathway and it is composed of a benzoquinone ring and an isoprenoid side chain, the last comprising 10 isoprene units (Bhagavan et al. 2007).
A Polyphenol-Based Multicomponent Nutraceutical in Dysmetabolism and Oxidative Stress: Results from a Pilot Study
Published in Journal of Dietary Supplements, 2018
Roberto Corsi, Giovanni Mosti, Attilio Cavezzi, Simone Ugo Urso, Gayla Dimitrova, Elena Fioroni, Roberto Colucci, Valentina Quinzi
In the context of dietary supplements of proven utility in cardiovascular diseases, coenzyme Q10 (Ubidecarenone, Ubiquinone), which is ubiquitous in the human body, primarily in the mitochondria electron transport chain, represents a complementary ingredient when using lipid lowering substances such as monacolin k (Oleck & Ventura, 2016).