Hairdressing Products: Contact Urticaria Syndrome
Ana M. Giménez-Arnau, Howard I. Maibach in Contact Urticaria Syndrome, 2014
Natural hair colors are mainly plant derivatives and have become increasingly popular. Henna, senna, and chamomile are such natural hair dyes. Henna is derived from the leaves of Lawsonia alba. Skin and respiratory reactions, angioedema, and conjunctivitis from skin contact with henna or inhaling its small powder particles have been reported in hairdressers.[36–38,42] In all those cases, a prick test with henna was positive. However, a negative prick test with the coloring molecule of henna, 2-hydroxy-1, 4-naphtoquinone, may indicate that other compounds are responsible for these reactions.[37] Senna is an herbal remedy and is used in laxatives. It is also a constituent of hair dyes. Occupational asthma, rhinitis, and conjunctivitis have been seen due to exposure to senna and a positive prick test confirmed that senna was the responsible agent.[39]
Ex-Lax dermatitis
Alisa McQueen, S. Margaret Paik in Pediatric Emergency Medicine: Illustrated Clinical Cases, 2018
Laxatives containing senna are not recommended for children under 2 years of age. However, the appearance, especially of Ex-Lax, makes it very attractive to toddlers who do not realize it is a medication. Ex-Lax is a chocolate-flavored medication with squares wrapped in foil that appears very similar to candy. Each square can contain 15–25 mg of sennosides. Senna is an herb from which the extracts are obtained. The active components in senna extracts are anthraquinone derivatives and their glucosides, referred to as senna glycosides or sennosides. Sennosides irritate the lining of the colon causing peristalsis and promoting evacuation of stool. Senna may also enhance intestinal fluid accumulation and increase the moisture content of stool by inhibiting electrolyte and water re-absorption from the colon.
Anorectal malformation and soiling: Case study
Victoria A. Lane, Richard J. Wood, Carlos A. Reck-Burneo, Marc A. Levitt in Pediatric Colorectal and Pelvic Surgery, 2017
A 5-year-old boy is assessed for fecal incontinence.He was born with an anorectal malformation and a rectourethral fistula (level unknown).He was managed initially with a colostomy, then underwent a primary posterior sagittal anorectoplasty (PSARP) at 1 year of age, and the colostomy has since been reversed.The mother reports that she has tried rectal enemas previously without success, and the child’s current regimen is 45 mg of senna.He has abdominal cramping and vomiting after taking the senna and continues to have accidents throughout the day.He is incontinent of urine (day and night). No attempts have been made to potty train.
Syringic acid Attenuates Oxidative Stress in Plasma and Peripheral Blood Mononuclear Cells of Patients with Acute Myeloid Leukemia
Published in Nutrition and Cancer, 2023
Naghmeh Haddadi, Mehrzad Mirzania, Hadi Ansarihadipour
The uncontrolled generation of ROS, as well as defects in the antioxidant system of the human body, results in oxidative stress in AML patients (20). Therefore, it is hypothesized that treatment with antioxidant agents could reduce ROS production in cancer by scavenger systems (21). There is a growing interest in finding phytochemicals with antioxidant properties which can prevent cellular oxidative damage in cancer. Natural phenolic compounds comprise a wide range of herbal components, which are usually found in the human diet and represent therapeutic benefits (22). For instance, the rosemary plant is native to the Mediterranean region and has antioxidant, anticancer, anti-inflammatory, anti-diabetic, pain-relieving, and anti-microbial properties and is prescribed for the treatment of migraine, insomnia, cancer, and diabetes (23). In addition, the Senna plant has antioxidative, anti-inflammatory, and anti-apoptotic properties and is used for the treatment of kidney injury (24). SA is a phenolic compound that is abundantly found in olive, honey, spices, grape, acai palm, and pumpkin. It has beneficial properties in medicine, such as antioxidant, anticancer, anti-microbial, anti-diabetic, and anti-inflammatory activity, and it protects the heart, brain, and liver against oxidative stress (25).
PI-RADS v2 and periprostatic fat measured on multiparametric magnetic resonance imaging can predict upgrading in radical prostatectomy pathology amongst patients with biopsy Gleason score 3 + 3 prostate cancer
Published in Scandinavian Journal of Urology, 2018
Lingyun Zhai, Yu Fan, Shaoshuai Sun, Huihui Wang, Yisen Meng, Shuai Hu, Xiaoying Wang, Wei Yu, Jie Jin
All MRI studies were performed using one of three 3.0T MRI systems (Sigma HD, GE Medical Systems; Discovery MR750, GE Medical Systems, Little Chalfont, UK; Intera Achieva, Philips Medical Systems, Maplewood, MN, USA) without endorectal coil 4–6 weeks before prostate biopsy. The scan sequences included diffusion-weighted imaging (DWI) (b-values: 0, 800, and 1000 s/mm2),dual-echo T1-weighted imaging in the sagittal planes, fast-spin-echo T2-weighted imaging in the axial planes, and dynamic contrast-enhanced imaging (DCEI). The main MR imaging acquisition parameters are described in Supplemental data S1. The apparent diffusion coefficient map was generated from the DWI, with b-values of 0 and 800 s/mm2. The patients were asked to take senna leaf particles (a kind of traditional Chinese medicine) as a laxative one day before the examination.
Quercetin promotes gastrointestinal motility and mucin secretion in loperamide-induced constipation of SD rats through regulation of the mAChRs downstream signal
Published in Pharmaceutical Biology, 2018
Ji Eun Kim, Mi Rim Lee, Jin Ju Park, Jun Young Choi, Bo Ram Song, Hong Joo Son, Young Whan Choi, Kyung Mi Kim, Jin Tae Hong, Dae Youn Hwang
Constipation is well known as an acute or chronic gastrointestinal disease characterized by infrequent bowel movements, hard and dry faeces, incomplete bowel evacuation and difficulty during defecation (Walia et al. 2009). Until now, several drugs were developed to treat this disease. In most cases, chemical drugs (laxatives) including Senna™, Correctol®, Exlax®, Senokot™ and Gaviscon® act as stimulants to increase bulkiness and soften stool or as osmotic agents, trigger bowel movements and enhance water flow into the colon to promote elimination (Voderholzer et al. 1997). But, most of above drugs showed some undesirable side effects, such as myocardial infarction, artery contraction and coronary spasms (Lembo and Camilleri 2003; Busti et al. 2004; Kim et al. 2013). Therefore, many studies have focused on identifying novel laxatives with no side effects to treat constipation patients. As part of above studies, we investigated the laxative effect and action mechanism of QCT in Lop-induced constipation model. The results of the present study first demonstrated that QCT can improve the symptoms of constipation through the elevation of stool excretion, and the recovery of histological changes of the transverse colon in Lop-induced constipation model. Especially, our data show the laxative effects of QCT are tightly correlated with the interaction between QCT and mAChR M2/3 signalling pathway.
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