Cosmetic Components Causing Contact Urticaria Syndrome: An Update
Ana M. Giménez-Arnau, Howard I. Maibach in Contact Urticaria Syndrome, 2014
Another biguanide antimicrobial agent is polyhexanide or polyaminopropylbiguanide that may partly cross-react with chlorhexidine and that has shown to elicit IgE-mediated reactions from toilet paper [25] and wet wipes, as in a case we have diagnosed recently. This subject reacted positively on prick testing to the wipes and the antimicrobial agent and also had a positive basophil activation test; however, tests with chlorhexidine, another biguanide with which it may partially cross-react, remained negative. Polyhexanide is a poly-biguanide antiseptic, which is widely used, for example, in contact lens solutions, wound dressings, pool cleaners, and in cosmetics [25] (Figure 22.2).
Keratitis
Firza Alexander Gronthoud in Practical Clinical Microbiology and Infectious Diseases, 2020
Treatment of Acanthamoeba keratitis is mainly aimed at killing the amoebic cysts as opposed to the more sensitive trophozoites and consists of eye drops with two or three agents: Chlorhexidine 0.02%–0.06%Polyhexanide or polyhexamethylene biguanide (PHMB) 0,02% (most effective against the cysts)Propamidine isethionate (Brolene) of hexamidine
Therapeutic Approach in Fungal Keratitis
Mahendra Rai, Marcelo Luís Occhiutto in Mycotic Keratitis, 2019
Polyhexamethylene biguanide (PHMB), also known as polyhexanide, polyaminopropyl biguanide, polymeric biguanide hydrochloride or polyhexanide biguanide, is an antiseptic with antiviral and antibacterial properties used as an alternative for fungal keratitis treatment. It also shows a broad viricide and antifungal spectrum and has amoebicidal activity. Certainly, its antimicrobial efficacy has been demonstrated on Acanthamoeba polyphaga, A. castellanii, and A. hatchetti (Asiedu-Gyekye et al. 2015) by using 0.02 to 0.053% solutions without causing side effects.
Effect of polyhexanide as antiseptic mouth rinse against oral pathogens in an in vitro biofilm model
Published in Acta Odontologica Scandinavica, 2021
Maximilian Kollmuss, Konrad Tolksdorf, Sabina Noreen Wuersching, Reinhard Hickel, Karin Christine Huth
An antimicrobial agent that is used as a disinfectant in various medical fields is polyhexanide. Common indications for polyhexanide are the treatment of chronic wounds and infected total endoprostheses, but it is also used perioperatively for skin disinfection and as an intraoperative irrigation solution. However, polyhexanide can also be applied on mucous membranes and may therefore be a potential disinfectant for the oral mucosa [25–27].
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