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Gynecomastia
Published in Charles Theisler, Adjuvant Medical Care, 2023
Diet: It is best to avoid food and drink items that are high in phytoestrogens (e.g., flax-seeds, soybeans, wheat, beans, carrots, nuts, potatoes, coffee, alcohol, and marijuana) so that the condition will not worsen.5
Prostate Cancer
Published in Karl H. Pang, Nadir I. Osman, James W.F. Catto, Christopher R. Chapple, Basic Urological Sciences, 2021
Karl H. Pang, James W.F. Catto
DietaryAlcoholDairy: weak association.Tomatoes: favourable effect of tomato and lycopene.Phytoestrogens: reduced risk.Soy: reduced risk of PCa, but increased risk of advanced diseases.Vitamin D: both low and high concentrations are associated with increased risk.Vitamin E/selenium: inverse relationship between serum selenium levels and PCa.Selenium or Vitamin E supplements have no beneficial effect in preventing PCa.
Lifestyle Medicine in Menopause and Bone Health
Published in Michelle Tollefson, Nancy Eriksen, Neha Pathak, Improving Women's Health Across the Lifespan, 2021
Not all phytoestrogens are safe and beneficial. Hops, used in beer brewing, contains a potent phytoestrogen called 8-prenylnaringenin (8-PN). Because 8-PN binds to both alpha- and beta-estrogen receptors, it provides some relief from menopausal vasomotor symptoms.33–37 However, 8-PN has a much weaker affinity for the beta-receptor than for the alpha-receptor, which is a concern for potential increased breast cancer risk with use of hops-containing supplements and beer consumption.38,39
Genistein affects gonadotrophin-releasing hormone secretion in GT1-7 cells via modulating kisspeptin receptor and key regulators
Published in Systems Biology in Reproductive Medicine, 2022
Jingyuan Xiong, Ye Tian, Aru Ling, Zhenmi Liu, Li Zhao, Guo Cheng
Genistein, an important member of soy isoflavones, is a naturally occurring phytoestrogen displaying structural and functional similarities with 17β-estradiol, directly impacting the endocrine and reproductive systems (Křížová et al. 2019). Dietary genistein is considered to be a critical factor in advancing puberty and reproductive maturation for children and adolescents (Marks et al. 2017; Ali et al. 2020). In adults, supplements of isoflavones were reported to reduce menopausal symptoms, and lower the risk of breast and prostate cancer (Lethaby et al. 2007; Shu et al. 2009; Lund et al. 2011). On the contrary, case reports on a few women of reproductive age indicated that intake of phytoestrogens might exert adverse effects, including dysmenorrhea and endometriosis (Chandrareddy et al. 2008). Although numerous pieces of evidence suggested that genistein could affect endocrine and reproductive functions, the detailed cell and molecular effects and mechanisms remain to be clarified.
Kaempferol-induced GPER upregulation attenuates atherosclerosis via the PI3K/AKT/Nrf2 pathway
Published in Pharmaceutical Biology, 2021
Zhuo Feng, Changyuan Wang, Yue Jin, Qiang Meng, Jingjing Wu, Huijun Sun
For a long time, plant-derived oestrogen has been adopted as a therapeutic agent for human diseases, and currently, it plays an important role in health care practice. Recent findings indicate that the administration of phytoestrogens may be beneficial for the management of cancer, osteoporosis and neurodegenerative diseases (Lagari and Levis 2013; Langasco et al. 2019; Peiffer et al. 2020). With the advancement in science and more in-depth research, researchers extracted and separated effective phytoestrogens from Chinese herbal medicine and transformed the traditional medicine treatment to elucidate the underlying molecular mechanism (Wang X et al. 2006). Attractively, numerous studies found that phytoestrogens present satisfactory results as potential therapeutic options for AS (Kirichenko et al. 2017). In our current study, kaempferol alleviated OVX-HFD-derived AS in vivo and ox-LDL-induced injury in vitro. However, there are many obstacles to overcome a successful translation from basic experiments to clinical application. Future experiments should be conducted to explore the mechanism of kaempferol in alleviating AS to bring prosperity for its prevention and treatment, especially postmenopausal AS.
Ameliorative effects of quercetin on folliculogenesis in diabetic mice: a stereological study
Published in Gynecological Endocrinology, 2020
Ayeh Bolouki, Fatemeh Zal, Hossein Bordbar
Over the past years, there have been a number of investigations concerning the protective effects of phytoestrogens against reproductive disorders [6]. On these phytoestrogens, called quercetin, a well-known flavonoid is widely distributed in fruits and vegetables [7]. It has putative, beneficial effects, including antioxidant, anti-diabetic and anti-angiogenic effects, as well as, the anti-inflammatory activity and protective effects against post-menopausal bone loss [8,9]. Many studies regarding the effect of quercetin on the ovary suggests that it may be effective on the reproductive function and treatment of reproductive disorders [10]. The previous studies also have indicated that quercetin regenerates the pancreatic islets and increases insulin release in streptozotocin-induced diabetic animal models [11].