The twentieth century
Michael J. O’Dowd in The History of Medications for Women, 2020
Giles Brindley (1983) reported that the injection of phenoxybenzamine had relatively similar effects. Lechtenberg and Ohl (1994) wrote: ‘The effectiveness of phenoxybenzamine in inducing erection was underscored by the same Doctor Brindley at the American Urological Association Meeting in 1983. At the end of his lecture on the physiology of erection he informed the audience that he had self-administered phenoxybenzamine just prior to his lecture and then proceeded to display the result of his injection. Following this spectacular demonstration of the effectiveness of phenoxybenzamine, Doctor Brindley retired to less public settings, where he tested several intracavernosal agents on himself to find out whether or not they would induce erection’.
The Influence of Pituitary-Adrenal Axis on the Immune System
Istvan Berczi in Pituitary Function and Immunity, 2019
Treatment of rabbits with propranolol (20 mg/kg) enhanced both the passive hemagglutinating and the IgE response to ovalbumin. Phenoxybenzamine (0.4 to 40 mg/kg) had a similar adjuvant effect, but the response was delayed markedly at high doses.470 Catecholamines elevated cAMP levels in rabbit alveolar macrophages. Phagocytosis was accompanied by an increase of cAMP in macrophages, which preceded or coincided with the onset of other metabolic events. Dibutyryl cAMP, which mimics several actions of cAMP, stimulated oxygen consumption and hexose monophosphate activity in phagocytosing alveolar macrophages, whereas no significant change was observed in resting cells. In polymorphonuclear leukocytes the effect of dibutyryl cAMP was opposite to that seen in alveolar macrophages.471
Postjunctional Dopamine Receptor Stimulants
M.D. Francesco Amenta in Peripheral Dopamine Pathophysiology, 2019
The most remarkable aspect of the cardiovascular effects of fenoldopam is its capacity to increase renal blood flow. Threshold effects are obtained in the dog and cynomolgus monkey in response to doses as low as 0.1 μg/kg or 0.1 μg/kg/min i.v., and maximum increases (up to 80%) are achieved at about 40 μg/kg. Efficacy is therefore comparable to, or greater than, that of DA, and the compound is four to ten times more potent.23,25,29,32,39,40 When baroreceptor reflexes are eliminated with phenoxybenzamine, the vasodilator effects of the drug are even more pronounced.39 In accordance with the known distribution of DA1 receptors, vasodilation also occurs in the mesenteric vasculature,42 but not in the iliac artery when given by infusion.32 Coronary vessels do not dilate,35 despite in vitro evidence for the presence of DA1 receptors. This can probably be accounted for by a reduction in afterload and a corresponding reduction in left ventricular work and oxygen demand.
Preoperative adrenal artery embolization followed by surgical excision of giant hypervascular adrenal masses: report of three cases
Published in Acta Chirurgica Belgica, 2018
Ismail Cem Sormaz, Fatih Tunca, Arzu Poyanlı, Yasemin Giles Şenyürek
Preoperative management included medical treatment with α- and β-adrenergic blockers for blood pressure control. Three weeks before surgery, the patient was started on phenoxybenzamine 10 mg per day by mouth, which was gradually titrated up to 60 mg per day. The patient was also put on β-adrenergic blocker agent (propranolol-HCL) 40 mg per day concordant with gradual increasing doses of phenoxybenzamine. Preoperative adrenal artery embolization was planned for the right-sided adrenal mass in this patient. The main aim of the arterial embolization was to reduce hypervascularity and decrease troublesome bleeding during surgery. We also thought that TAE might help to prevent severe perioperative hypertensive attacks. The day before angiography and embolization, the average blood pressure and heart rate of the patient were 123/62 mm Hg and 65 bpm, respectively. Equipment for close hemodynamic monitoring and management of possible hypertensive attacks during angiography and embolization was maintained.
Current evidence for pharmacologic therapy following stage 1 palliation for single ventricle congenital heart disease
Published in Expert Review of Cardiovascular Therapy, 2022
Meredith C. G. Broberg, Ira M Cheifetz, Sarah T Plummer
The interstage single ventricle is a volume-loaded ventricle supporting two circulations. In the immediate postoperative period, decreasing systemic vascular resistance with potent vasodilators, such as milrinone and, in some centers, phenoxybenzamine, can improve postoperative hemodynamics including the balance between pulmonary and systemic circulations [15–19]. Beyond the immediate postoperative period, there is a paucity of literature regarding the need for afterload reduction.
Adrenergic receptor behaviors of mesenchymal stem cells obtained from different tissue sources and the effect of the receptor blockade on differentiation
Published in Journal of Receptors and Signal Transduction, 2022
Erkan Maytalman, Arash Alizadeh Yegani, Ilknur Kozanoglu, Fazilet Aksu
Given MTT test results, phenoxybenzamine was studied at dose of 1 µM in order to ensure use at the same concentration with propranolol and to prevent adverse effect on proliferation. In the literature search, we found no study using phenoxybenzamine in stem cell cultures. However, dose of 1 µM was used in addition to another active substance in a study using cancer cell lines [26].
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