Main Classes of Drugs
Jerome Z. Litt, Neil H. Shear in Litt's Drug Eruption & Reaction Manual, 2017
CNS stimulantCocaineDexmethylphenidateDextroamphetamineLisdexamfetamineModafinil
Toxicity of acute exploratory amphetamine-salt medication in amphetamine-naïve pediatrics: a retrospective cohort study
Published in Clinical Toxicology, 2020
James B. Leonard, Amy Kruger Howard, Elizabeth Q. Hines
Cases were included if they were acute, single-substance exposures to a non-illicit amphetamine salt in the defined age criteria. Cases were excluded if the exposure was to other amphetamines (e.g., phentermine, methamphetamine), the exposure was to lisdexamfetamine, the exposure was acute-on-chronic, the patient was non-naïve to stimulants, if the patient was not followed to a known final outcome, the dose was unavailable, or the weight was unknown. Cases were identified using the generic code for amphetamine according to Poisindex (001000). Acute-on-chronic ingestions were defined as a patient taking a higher-than-normal dose for a medication they use chronically. Acute-on-chronic exposures were excluded because prior development of tolerance might falsely increase the median dose of those patients who were asymptomatic and untreated. Lisdexamfetamine is a pro-drug of dextroamphetamine with a delayed time to peak of approximately 3.5 h. One study published in abstract recommends a triage dose of 3 mg/kg and the toxicity seems to differ from the classic amphetamines used for treatment of ADHD [9].
Attention-deficit hyperactivity disorder symptomatology, binge eating disorder symptomatology, and body mass index among college students
Published in Journal of American College Health, 2020
Jennifer A. Hanson, Lisa N. Phillips, Susan M. Hughes, Kimberly Corson
It has been hypothesized that both the impulsive component and the inattentive component of ADHD may play a role in the cultivation of disordered eating.26 Binge eating and ADHD have been conceptualized as disorders of impaired self-regulation. Poor inhibitory control may contribute to overeating.27 Likewise, deficits in attention may result in disordered eating possibly as the result of inattentiveness to internal hunger and satiety cues.28 In addition, the likely anxiety and frustration associated with attention difficulties could result in the use of food as part of a compensatory mechanism.29 Both ADHD and binge eating have been found to be associated with body weight status. In addition, the two appear to share common neurobiological mechanisms.30 Recently, lisdexamfetamine dimesylate, a stimulant medication used for the treatment of ADHD, has been shown to reduce binge eating in individuals with BED with study results suggesting that weight loss may also be an outcome of the use of this drug among those with BED.31
High-intensity, sport-specific cardiac rehabilitation training of a 22-year-old competitive cyclist after spontaneous coronary artery dissection
Published in Baylor University Medical Center Proceedings, 2018
Nicholas Weber, Adam Weber, Pasquale Carbone, Anne Lawrence, Tim Bilbrey, Jeffrey M. Schussler, Jenny Adams
A 22-year-old male cyclist with attention deficit hyperactivity disorder presented to the Baylor University Medical Center, Dallas, Texas, emergency department with severe (8 out of 10) substernal chest pain. He complained of dyspnea, nausea, and vomiting, as well as pain radiating to his left arm and neck. The pain started while he was cycling at a popular outdoor trail and had resolved by the time he arrived at the hospital. He had been taking lisdexamfetamine for about 5 months. A computed tomography coronary angiogram revealed a dissection within the proximal left anterior descending artery.6 His cardiologist referred him to a cardiac rehabilitation (CR) program at Baylor Heart and Vascular Hospital, Dallas, Texas, that specializes in high-intensity, sport-specific exercise training.7–11
Related Knowledge Centers
- Anorexia
- Anxiety
- Binge Eating Disorder
- Insomnia
- Irritability
- Stimulant
- Attention Deficit Hyperactivity Disorder
- Diarrhea
- Methylphenidate
- Oral Administration