Herbs with Antidepressant Effects
Scott Mendelson in Herbal Treatment of Major Depression, 2019
Hibiscus rosa-sinensis, commonly referred to as simply hibiscus, is a flowering plant of the Malvaceae family native to East Asia. The flowers are best known for their beauty. However, the flowers are both edible and contain medicinal phytochemicals. They are rich in flavonoids, including quercetin, cyanidin, kaempferol, myricetin, pelargonidin, peonidin, delphinidin, petunidin, and malvidin, though the content varies across different colors and breeds.1 Roots, leaves, and stems are also used. The genus Hibiscus contains approximately 200 species distributed throughout tropical and subtropical regions. Various closely related species of Hibiscus are used medicinally, and are believed to exert anticonvulsant, antioxidant, anti-inflammatory, antimicrobial, laxative, sedative, and antidepressant depressant effects.2
Gestational Weight Gain and Postpartum Obesity
Priyanka Bhatt, Maryam Sadat Miraghajani, Sarvadaman Pathak, Yashwant Pathak in Nutraceuticals for Prenatal, Maternal and Offspring’s Nutritional Health, 2019
Hibiscus sabdariffa tea is in extensive use across the globe both as a beverage and as a treating agent for hyperlipidemia. [42] Hibiscus sabdariffa L. (Malvaceae; common name “roselle”) is a plant cultivated in Sudan and Eastern Taiwan. [43] The flower of the plant is “generally recognized as safe” (GRAS) as a food by the US Food and Drug Administration (FDA). It is highly beneficial in the sense that it contains potent antioxidant, antihyperlipidemic, antiatherosclerotic as well as hepatoprotective properties. H. sabdariffa are rich in anthocyanins, which are known to be effective in controlling weight gain and treating obesity. [43, 44] In a study conducted on high-fat diet-induced Mesocricetus auratus hamster, it was found that the floral extracts of H. sabdariffa could be effective in controlling body weight and adipose deposition. [43]
Naturopathic Medicine and the Prevention and Treatment of Cardiovascular Disease
Stephen T. Sinatra, Mark C. Houston in Nutritional and Integrative Strategies in Cardiovascular Medicine, 2015
In addition to consuming filtered water, some studies show promising reductions in blood pressure with the use of hibiscus tea. Hibiscus flowers contain anthocyanins, which are thought to exhibit blood pressure–lowering effects through mild ACE inhibitor and diuretic actions. In a randomized, double blind, and placebo-controlled trial, 3240 mL servings per day of hibiscus tea were administered for 6 weeks to prehypertensive and mildly hypertensive adults. Compared to placebo, those consuming hibiscus tea had lower SBP and DBP by 7.2 and 3.1 mmHg, respectively.45 In two other RCTs (one of them double blinded), hibiscus tea was almost comparable to the ACE inhibitors lisinopril and captopril in lowering blood pressure with a wide margin of tolerability and safety.46,47
Phenolic Constituents and Inhibitory Effects of Hibiscus sabdariffa L. (Sorrel) Calyx on Cholinergic, Monoaminergic, and Purinergic Enzyme Activities
Published in Journal of Dietary Supplements, 2018
Ganiyu Oboh, Taiwo M. Adewuni, Adedayo O. Ademiluyi, Tosin A. Olasehinde, Ayokunle O. Ademosun
Hibiscus sabdariffa L. belongs to the Malvaceae family and is commonly referred to as sorrel, roselle, sour tea, or karkade in different parts of the world (Mohd-Esa et al., 2010). It is an annual herbaceous herb with white to pale yellow flowers and fleshy red or white calyx, depending on the variety. It is widely cultivated in tropical Africa, Mexico, Central America, and Southeast Asia. Although the leaves and seeds are used as ingredients for salad, curries, and potherbs, the calyx is the most commonly used part of the plant. The calyx is used as an ingredient for the production of ice cream, beverages, jam, wine, and butter (Oboh, 2009). In Nigeria, the calyx is soaked in water to produce drinks and infusions. Furthermore, the calyx is rich in anthocyanins such as delphinidin 3-sambubioside and cyanidin 3-sambubioside (Da-Costa-Rocha et al., 2014). These red pigments are classified as polyphenols. Previous findings have revealed that sorrel extracts and infusions are effective in the treatment of several diseases, such as leukemia, hypertension, atherosclerosis, hyperlipidemia, breast cancer, lung cancer, ulcerative colitis, and pyrexia (Da-Costa-Rocha et al., 2014; Chen et al., 2013). Due to its phenolic constituents, sorrel calyx has been shown to exhibit strong antioxidant activities. Previous reports from our laboratory have revealed the antidiabetic, radical-scavenging, and metal-chelating activities of sorrel extract (Oboh, 2009). To the best of our knowledge, there are no sufficient data on the neuroprotective properties of sorrel calyx.
Delphinidin-3-O-glucoside, an active compound of Hibiscus sabdariffa calyces, inhibits oxidative stress and inflammation in rabbits with atherosclerosis
Published in Pharmaceutical Biology, 2022
Bo Sun, Fangda Li, Xu Zhang, Wei Wang, Jiang Shao, Yuehong Zheng
Preclinical, clinical, and epidemiological research showed that anthocyanins are abundant and widely found in medicinal plants, which possess prevention effects against cardiovascular disease via acting on multiple targets (Lee et al. 2017; Wood et al. 2019), indicating potential protective effects of anthocyanins on atherosclerosis (Garcia and Blesso 2021). Hibiscus sabdariffa L. (Malvaceae) (Roselle) is often used in traditional medicine for the treatment of various diseases, such as cancer, hyperlipidaemia, and hypertension (Riaz and Chopra 2018). A previous report indicated that an aqueous extract from Hibiscus sabdariffa suppresses the progression of atherosclerosis in rabbits (Chen et al. 2003). Delphinidin-3-O-glucoside (DP) is a pharmacologically active compound of Hibiscus sabdariffa. It has been reported that DP suppressed oxLDL-induced cell proliferation apoptosis and inhibition in primary human umbilical vein endothelial cells (Jin et al. 2013). DP was previously shown to be a powerful vascular protective agent that could inhibit oxLDL-evoked injury in human umbilical vein endothelial cells (Jin et al. 2014).
Effects of Hibiscus sabdariffa calyces on spatial memory and hippocampal expression of BDNF in ovariectomized rats
Published in Nutritional Neuroscience, 2022
Gerardo Lorenzana-Martínez, Anne Santerre, Isaac Andrade-González, Jacinto Bañuelos-Pineda
Plants of Hibiscus sabdariffa (Tempranilla variety) were collected from Jalisco, Mexico. The HSE extract was prepared using 10 kg of fresh calyces macerated for 7 days at 20°C in 100 L of 30% ethanol. The macerated material was filtered and then concentrated with a rotary evaporator at 35°C. The concentrated aqueous solution was then dried in a Niro spray dryer [24]. This protocol produced approximately 10 g/L of extract filtrate with 3% moisture and a pH of 3.4 [8].
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- Okra
- Woody Plant
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- Fruit
- Hybrid
- Roselle
- Sorrel
- Vegetable