Person Centered Medicine and Person-Directed Medical Care:
Miner Gary, Miner Linda, Dean Darrell in Healthcare’s Out Sick – Predicting A Cure – Solutions That Work !!!!, 2019
Personalized medicine emerges from predictive analytics—from an accurate prediction based on a thorough knowledge of the individual patient: of the patient’s genomic, psychological, and environmental make-up, which could then predict future problems as well as current recommendations for health. Personalized medicine would encompass preventive actions, specific medications, and specific treatments for that individual. Physicians had the feeling that they were practicing the best medicine possible due to their reliance on research and on the gold standards that arose from such research. The future of medicine is two-fold: treatment of current illnesses of the individual and preventing future illnesses. The role of the patient is changing to chief executive officer of healthcare. The best situation develops when both patient and physician believe that patients should participate in their own healthcare as much as possible. The best and safest medicine is syrup containing guaifenesin and dextromethorphan.
Case Report: Anaphylactic Reaction to Guaifenesin
Published in Hospital Practice, 2009
Manujendra Ray, Bela Faltay, Nairmeen Awad Haller
Adverse drug reactions lead to a significant number of hospital admissions each year and thus contribute to the overall financial burden of health care. Some of these drug reactions are allergic responses. As the overall predictability of allergic responses to drugs remains low, efforts to improve our understanding of the processes underlying these responses continue as we strive toward the ultimate goal of primary prevention. Allergic reactions range from mild pruritic to severe systemic anaphylactic responses. We report a case of a young healthy man who developed an anaphylactic reaction to an over-the-counter expectorant. A skin test showed that the patient had an immunoglobulin E-mediated allergic response to guaifenesin, one of the components of commonly available cough medications. Our review of published literature showed that this is the first report of a severe allergic response to guaifenesin.
Effect of guaifenesin on mucin production, rheology, and mucociliary transport in differentiated human airway epithelial cells
Published in Experimental Lung Research, 2011
JeanClare Seagrave, Helmut Albrecht, Yong Sung Park, Bruce Rubin, Gail Solomon, K. Chul Kim
Guaifenesin is widely used to alleviate symptoms of excessive mucus accumulation in the respiratory tract. However, its mechanism of action is poorly understood. The authors hypothesized that guaifenesin improves mucociliary clearance in humans by reducing mucin release, by decreasing mucus viscoelasticity, and by increasing mucociliary transport. To test these hypotheses, human differentiated airway epithelial cells, cultured at an air-liquid interface, were treated with clinically relevant concentrations of guaifenesin by addition to the basolateral medium. To evaluate the effect on mucin secretion, the authors used an anzyme-linked immunosorbent assay (ELISA) to measure the amounts of MUC5AC protein in apical surface fluid and cell lysates. To measure mucociliary transportability, additional cultures were treated for 1 or 6 hours with guaifenesin, and the movement of cell debris was measured from video data. Further, the authors measured mucus dynamic viscoelasticity using a micro cone and plate rheometer with nondestructive creep transformation. Guaifenesin suppressed mucin production in a dose-dependent manner at clinically relevant concentrations. The reduced mucin production was associated with increased mucociliary transport and decreased viscoelasticity of the mucus. Viability of the cultures was not significantly affected. These results suggest that guaifenesin could improve mucociliary clearance in humans by reducing the release and/or production of mucins, thereby altering mucus rheology.
Kinetics and Mechanism of Drug Release From Calcium Alginate Membrane Coated Tablets
Published in Drug Development and Industrial Pharmacy, 1994
H. R. Bhagat, R. W. Mendes, E. Mathiowitz, H. N. Bhargava
Compressed tablets containing guaifenesin (model drug), calcium acetate (reactant) and pharmaceutical excipients were prepared. The tablets were coated with calcium alginate hydrogel using a novel, self-correcting membrane coating technique. Effects of coating time, the type of alginate polymer and pH of the dissolution medium on the rate of drug release were evaluated. In distilled water, zero order drug release profiles were obtained from the coated tablets. The release rate decreased with an increase in the coating time (increased coat thickness) and molecular weight of alginate polymer. The release rate constants correlated with model for spherical reservoir system and, were used to calculate permeability of guaifenesin in the calcium alginate coatings. Alginate polymer with higher guluronic acid content provided acid stable coating and higher molecular weight polymer produced membrane with lower permeability for guaifenesin.
Related Knowledge Centers
- Airway
- Expectorant
- Guaiacol
- Pharmaceutical
- Over-The-Counter
- Spitting
- Phlegm