Use of Nanocarriers to Enhance Artemisinin Activity
Tariq Aftab, M. Naeem, M. Masroor, A. Khan in Artemisia annua, 2017
The pharmacokinetics and tissue distribution after intravenous administration of DHA in NLCs and in solution were compared. Glycerol monostearate and Miglyol® 812 were used as solid lipid and liquid lipid materials, respectively. The surfactants used were Tween 80 (1%) and Poloxamer 188 (1%). Each preparation was injected through the tail vein at the DHA dose of 10 mg/kg. Following intravenous administration of the DHA solution, the mean measured peak plasma concentration achieved was 917.51 ng/mL, and for the drug-loaded NLCs it was 289.28 ng/mL. After 2 h, the plasma concentration was lower for the DHA solution than for the drug-loaded NLCs because of its solubility in plasma and ensuing rapid distribution and elimination, and the slower release of DHA from NLCs, which led to lower clearance. The AUC (0 ∼ ∞) increased from 633.97 ng/mL/h for the drug solution to 1382.45 ng/mL/h for the drug-loaded NLCs. However, the clearance decreased from 15.77 to 7.23 (mg/kg/h·(ng/mL)) accordingly.
Chemistry and Biology of Monoglycerides in Cosmetic Formulations
Eric Jungermann, Norman O.V. Sonntag in Glycerine, 2018
Monoesters of saturated fatty acids are important for use in cosmetic preparation even though the highly purified glycerides are somewhat expensive. While monoglycerides of unsaturated fatty acids have unique properties, it is only the form of the double bond that is biologically active. In large-scale commercial production of unsaturated monoglycerides, some trans form of the unsaturated fatty acids becomes evident. Saturated fatty acids obtained from animal or vegetable fats (C14, C16, C18) predominate, with glycerol monostearate being the most popular.
Choline and PEG dually modified artemether nano delivery system targeting intra-erythrocytic Plasmodium and its pharmacodynamics in vivo
Published in Drug Development and Industrial Pharmacy, 2021
Ruili Wang, Guangyu Shi, Liqing Chai, Rongrong Wang, Guoshun Zhang, Guolian Ren, Shuqiu Zhang
Artemether (purity ≥99.0%) was supplied by Chongqing Huali Wulinshan Pharm. Co., Ltd. (Chongqing, China). Glycerol monostearate (GMS) was purchased through the Tianjin Guangfu Fine Chemical Research Institute (Tianjin, China). Medium-chain triglyceride (MCT) was supplied by the Sasol Chemical Co., Ltd. (Nanjing, China). Polyoxyl 40 hydrogenated castor oil (RH40) was obtained through the Shanghai Yunhong Chemical Preparation Auxiliary Tech Co., Ltd. (Shanghai, China). The PEG stearate (n = 40) (PEG2000-SA) was provided by Tokyo Chemical Industry (Shanghai, China). The choline-PEG derivative (CD-PEG-SA) was designed by our laboratory. Coumarin-6 (C6) was purchased through Beijing Bailingwei Tech. Co., Ltd. (Wuhan, China). The Hoechst 33342 was supplied by Thermo Fisher Scientific Inc. (Shanghai, China).
L-Ascorbic acid and phosphatidylcholine complex vesicles: formation and elucidation of their biological activities, and their molecular interactions
Published in Journal of Microencapsulation, 2023
Thapakorn Tree-Udom, Chalermrat Simavong, Prapasiri Phetklung, Kanjanaporn Chompoonuch, Sagaw Prateepchinda, Supatchaya Jaemsai, Andrew William King, Oraphan King
L-ascorbic acid, AA (99%) was obtained from the SIGMA-ALDRICH Corporation, Germany. PHOSPHOLIPON 90 G was purchased from Lipoid GmbH, Germany. Potassium dihydrogen phosphate was obtained from Loba Chemie Pvt. Ltd., India. Disodium hydrogen phosphate was obtained from Northern Chemicals and Glasswares Ltd., Part., Thailand. Ethanol, absolute grade was obtained from QREC Chemical Co., Ltd. New Zealand. Glycerine was purchased from Thai Glycerine Co.,Ltd., Thailand. Hydroxyethylcellulose was purchased from Ashland Inc, US. Glycerol monostearate was purchased from Zohar Dalia Ltd., Israel. Sweet almond oil was purchased from Henry Lamotte Oils GmbH, Germany. Phenoxyethanol was purchased from Sharon-Laboratories Ltd., Israel. Centrifugal Filter tube (4 mL, MW cut-off 30KDa) and cellulose membrane (Whatman® cellulose acetate membranes) were purchased from Sigma-Aldrich. Quartz cuvettes (Opti Glass/France) was purchased from NCG Ltd.
In vivo and in vitro evaluation of pulmonary administration of itraconazole nanostructured lipid carriers for pulmonary aspergillosis
Published in Drug Development and Industrial Pharmacy, 2023
Yanming Wang, Zhang Chenghao, Zhaoli Wu, Xinran Cui, Jinmei Ren, Jingling Tang
The Itz and clotrimazole reference standards were purchased from the National Institutes for Food and Drug Control (Beijing, China). Tween 80 was obtained from Shanghai Shan Pu Chemical Industry Co., Ltd. (Shanghai, China). Brij 78 was obtained from Sigma-Aldrich (St. Louis, MO). Amobarbital Sodium was obtained from Henan Nachuan Biotechnology Co. Ltd. (Henan, China). SDS was obtained from Sigma-Aldrich (St. Louis, MO). Oleic acid were obtained from Guangfu (Tianjin, China). Glycerol monostearate (GMS, emulsifying), Capryol 90, and Transcutol P were obtained from GATTEFOSSE (Shanghai, China). Cremophor EL was obtained from Aladdin (Shanghai, China). All other chemicals were of analytical grade and obtained commercially.
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