Drug interactions
Mervyn Dean, Juan-Diego Harris, Claud Regnard, Jo Hockley in Symptom Relief in Palliative Care, 2018
Interactions are more likely to be a problem: with the following drug groups: antacids, antibiotics, anticoagulants, antidepressants, antidiabetics, anticonvulsants, antifungals, cardiac drugs, corticosteroids, diuretics, NSAIDs and ulcer healing drugs with the following drugs (in descending order of number of likely interactions): carbamazepine, warfarin, diltiazem, verapamil, furosemide, cimetidine, methotrimeprazine, itraconazole, ketoconazole, amiodarone, dexamethasone, prednisolone and erythromycin in drugs with a narrow margin between therapeutic and toxic doses, e.g. digoxin when an interacting drug is started or stopped.
Chronic heart failure
Ann Richards in Nursing & Health Survival Guide, 2014
Drugs used to treat CHF include: Diuretics – usually furosemide ACE-inhibitors or angiotensin II receptor blockers (ARBs) Hydralazine (a vasodilator drug) in combination with nitrates if intolerant of ACE-inhibitors and ARBs Beta-blockers – reduce the effects of stimulation of the sympathetic nervous system Spironolactone – an aldosterone antagonist Digoxin – usually if atrial fibrillation is present
Diuretics and other renal drugs
Alan Galbraith, Shane Bullock, Elizabeth Manias, Barry Hunt, Ann Richards in Fundamentals of Pharmacology, 2007
The drugs furosemide, ethacrynic acid and bumetanide act on the medullary part of the ascending limb of the loop (loop of Henle) of the nephron. They inhibit the reabsorption of chloride and sodium ions from the loop into the interstitial fluid. The result is that the interstitial fluid becomes relatively hypotonic. If a high concentration of ions is present here, water will flow from the adjacent collecting duct into the interstitial fluid and back into the bloodstream. Good control of water balance is achieved by alterations in the permeability of the collecting duct to water by the presence of antidiuretic hormone (ADH) from the posterior pituitary gland. This is one of the major control systems for water balance, and slight interference here will completely upset the normal function of the kidney and result in a variation in urine output. A hypotonic interstitial fluid will result in a diuresis.
Optos Optomap Panoramic 200MA™ Imaging of a Serous Choroidal Detachment Responsive to Furosemide
Published in Seminars in Ophthalmology, 2009
Sumit P. Shah, Atul Jain, Irena Tsui, Tara A. McCannel
Purpose: To describe a case of a serous choroidal detachment which resulted after discontinuation of furosemide and illustrate the utility of ultrawide-angle fundus imaging in documenting this lesion in the retinal periphery. Design: Observational case report. Method: An 85 year old female presented with symptoms of a “brown curtain” descending over the left eye which was temporally related to recent discontinuation of oral furosemide. Ultrawide-field photography allowed for accurate documentaton of the choroidal detachments. Result: After resuming furosemide, the serous choroidal detachments resolved. Conclusion: We hypothesize a shift of free water following discontinuation of furosemide as a novel etiology for the development of serous chordoidal detachments. Ultrawide-field fundus photography was useful to document this lesion.
The prognostic value of the furosemide stress test in predicting delayed graft function following deceased donor kidney transplantation
Published in Biomarkers, 2018
Blaithin A. McMahon, Jay L. Koyner, Tessa Novick, Steve Menez, Robert A. Moran, Bonnie E. Lonze, Niraj Desai, Sami Alasfar, Marvin Borja, William T. Merritt, Promise Ariyo, Lakhmir S. Chawla, Edward Kraus
Objectives and methods: The Furosemide Stress Test (FST) is a novel dynamic assessment of tubular function that has been shown in preliminary studies to predict patients who will progress to advanced stage acute kidney injury, including those who receive renal replacement therapy (RRT). The aim of this study is to investigate if the urinary response to a single intraoperative dose of intravenous furosemide predicts delayed graft function (DGF) in patients undergoing deceased donor kidney transplant. Results: On an adjusted multiple logistic regression, a single 100 mg dose of intraoperative furosemide after the anastomosis of the renal vessels (FST) predicted the need for RRT at 2 and 6 h post kidney transplantation (KT). Recipient urinary output was measured at 2 and 6 h post furosemide administration. In receiver-operating characteristic (ROC) analysis, the FST predicted DGF with an area-under-the curve of 0.85 at an optimal urinary output cut-off of
Management of chronic hypertension during pregnancy with furosemide, amlodipine or aspirin: a pilot clinical trial
Published in The Journal of Maternal-Fetal & Neonatal Medicine, 2014
Paulino Vigil-De Gracia, Leyvis Dominguez, Alcibiades Solis
Objective: To determine the maternal and neonatal efficacy and safety with furosemide, amlodipine or aspirin in women with mild/moderate chronic hypertension during pregnancy. Methods: A pilot clinical trial was performed in a tertiary teaching hospital in Panama. Pregnant patients with mild/moderate chronic hypertension at ≤20 weeks of gestation were invited to take part in the study. Mild/moderate chronic hypertension was defined as a pregnancy with systolic blood pressure of 140–159 mmHg or diastolic blood pressure of 90–109 mmHg. Women in the furosemide group received 20 mg of furosemide oral each day, those in the amlodipine group received 5 mg of amlodipine oral each day and those in the aspirin group received 75 mg of orally-administered acetylsalicylic acid each day. Results: We enrolled 63 patients during the study period, 21 women were randomised to each group (aspirin, amlodipine and furosemide). We found no difference in maternal complications, pre-term births, mean birth weight or in the proportion of small for gestational age infants among treatment groups. Severe hypertension and aggregate pre-eclampsia were similar among treatment groups. Conclusion: This pilot trial demonstrates that both furosemide and amlodipine might have the same effect during pregnancy. However, a large clinical trial is necessary to prove this.
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