Herbal Therapy for Cancer
Prakash Srinivasan Timiri Shanmugam in Understanding Cancer Therapies, 2018
Epigallocatechin gallate has been identified as a powerful antioxidant, preventing oxidative damage in vivo, but also as an anti-angiogenic and antitumor agent and as a modulator of tumor cell response to chemotherapy. The anticancer properties of EGCG present in green tea extract are said to induce apoptosis and cell cycle arrest by altering the expression of cell cycle regulatory proteins, activating caspases, and suppressing oncogenic transcription factors. In vitro studies have demonstrated that EGCG blocks carcinogenesis by affecting a wide array of signal transduction pathways including JAK/STAT, mitogen-activated protein kinase (MAPK), PI3 K/AKT (phosphoinositide-3-kinase/protein kinase B), Wnt, and Notch. EGCG stimulates telomere fragmentation through inhibiting telomerase activity; further, several clinical studies have revealed that treatment by EGCG inhibits solid tumor incidence in different organs, such as liver, stomach, skin, lung, mammary gland, and colon (Singh et al. 2011).
Nutrition Part I
Mark C Houston in The Truth About Heart Disease, 2023
Several dietary and nutritional components have been shown to decrease inflammation by interrupting the inflammatory vascular receptors (8). These include the following:Curcumin (turmeric).Cinnamaldehyde (cinnamon).Sulforaphane (broccoli).Resveratrol (nutritional supplement, red wine, grapes).Epigallocatechin gallate (EGCG) (green tea).Luteolin (celery, green pepper, rosemary, carrots, oregano, oranges, olives).Quercetin (tea, apples, onion, tomatoes, capers).
Treatment
William Bonnez in Guide to Genital HPV Diseases and Prevention, 2019
Veregen is the latest addition to the therapeutic armamentarium. This is a 15% ointment of kunecatechins, compounds that are obtained by partial purification of a water extract of green tea (Camellia sinensis). Epigallocatechin gallate is the most abundant compound. The mode of action is not clearly established. When compared to placebo, Veregen has shown superior efficacy for the self-treatment of external genital warts. The recommended duration of treatment and the side-effects are similar to those of imiquimod, but the need for thrice daily application and a red color that may stain underwear are substantial inconveniences. It should not be used during pregnancy. - Kunecatechins(Veregen; 15-g tube): 15% ointment applied three times a day for up to 16 weeks.
Comparison of antiproliferative effect of epigallocatechin gallate when loaded into cationic solid lipid nanoparticles against different cell lines
Published in Pharmaceutical Development and Technology, 2019
Amélia M. Silva, Carlos Martins-Gomes, Joana F. Fangueiro, Tatiana Andreani, Eliana B. Souto
Epigallocatechin gallate (EGCG) is the major polyphenol found in green tea (Camellia sinensis L.) which has been gaining special interest in food and pharmaceutical industries. EGCG has revealed several beneficial health effects, including anti-inflammatory (Cavet et al. 2011), anti-carcinogenic (Farabegoli et al. 2011; Santos et al. 2013; Radhakrishnan et al. 2016; Shin et al. 2016), antioxidant (Cavet et al. 2011; Zhou and Elias 2013), anti-angiogenic (Yamakawa et al. 2004; Piyaviriyakul et al. 2011), anti-diabetic (Wolfram et al. 2006; Chen et al. 2009) and anti-bacterial (Lee et al. 2017). It has also been reported its use as chondroprotective agent as it suppressed the inflammatory response in osteoarthritis models (Akhtar and Haqqi 2011; Min et al. 2015), as well as a cardiovascular protector (Wolfram 2007; Oyama et al. 2017) and neuroprotector (Lee et al. 2015; Ortiz-López et al. 2016). EGCG is the most powerful catechin present in the green tea, regarding the chemopreventive and apoptosis-inducing molecules (Azam et al. 2004).
Green Tea Consumption and Esophageal Cancer Risk: A Meta-analysis
Published in Nutrition and Cancer, 2020
Yu Yi, Hailong Liang, Huang Jing, Zhang Jian, Yang Guang, Zhang Jun, Hongfa Zhu, Li Jian
Tea, which is the second most common drink after water, is widely grown in more than 30 countries around the world with an annual yield of 2,500,000 tons (36). Various studies have investigated the protective effect of tea against cancer due to its antioxidant, anti-inflammatory and antitumor effects (7,8). The main active ingredients of tea are polyphenols, and the most common are epigallocatechin gallate, epigallocatechin gallate, epigallocatechin gallate and epicatechin (37). Studies have shown that epigallocatechin gallate has a significant anti-tumor effect, since it can inhibit the proliferation of cancer cells and promote their apoptosis by reducing the activity of enzymes and hindering the signal transduction pathway (38). An hour after consumption of green tea, high concentrations of catechin and theaflavins can be detected in saliva, suggesting that tea polyphenols can selectively inhibit the proliferation of oral cancer cells and induce apoptosis (39).
Enhanced therapeutic efficacy of doxorubicin against multidrug-resistant breast cancer with reduced cardiotoxicity
Published in Drug Delivery, 2023
Tianyu Zhang, Nuannuan Li, Ru Wang, Yiying Sun, Xiaoyan He, Xiaoyan Lu, Liuxiang Chu, Kaoxiang Sun
Epigallocatechin gallate (EGCG), a natural antioxidant component (Gan et al., 2018) which can be used as an antioxidant in various food additives, has also been used in the treatment of anti-tumor, cardiovascular diseases and other diseases (Wang et al., 2018). It can effectively remove oxygen free radicals in the body (Cheng et al., 2016). In addition to this, studies also show that EGCG can significantly inhibit the expression of P-gp (Satonaka et al., 2017). Therefore, the combination of DOX and EGCG can effectively prevent the cardiotoxicity of DOX and reverse the MDR in tumor cells. However, since EGCG is easily oxidized even under common physiological condition (Ziaunys & Smirnovas, 2022), it is critical to design a method that can not only protect the EGCG molecule from oxidation, but also effectively transport EGCG and DOX to the action site.
Related Knowledge Centers
- Dietary Supplement
- Ester
- Gallic Acid
- Polyphenol
- Polyphenol Oxidase
- Gallocatechol
- Catechin
- Tea
- Theaflavin
- Plum