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Monographs of Topical Drugs that Have Caused Contact Allergy/Allergic Contact Dermatitis
Published in Anton C. de Groot, Monographs in Contact Allergy, 2021
Dimethindene is an indene histamine H1 antagonist. It is indicated as symptomatic treatment of allergic reactions such as urticaria, allergies of the upper respiratory tract such as hay fever and perennial rhinitis, and food and drug allergies. It is also used for pruritus of various origins, e.g. from insect bites, varicella, eczema and other pruriginous dermatoses on account of its sedative properties. In pharmaceutical products, dimethindene is employed as dimethindene maleate (CAS number 3614-69-5, EC number 222-789-2 [Dimetindene hydrogen maleate], molecular formula C24H28N2O4) (1).
The clinical relationship between histamine-1 receptor antagonists and risk of cancer: a systematic review and meta-analysis
Published in Expert Review of Anticancer Therapy, 2023
Elham Bakhtiari, Nasrin Moazzen, Amir Amirabadi, Hamid Ahanchian
The risk of cancer was investigated in all case-control studies [10,13,16–18]. The risk of breast cancer was investigated in two studies [16,18]. Kelly et al. [16] studied the risk of breast cancer according to use of antihistamines in 11,628 women. Relative risk was estimated for regular use of antihistamines (>4 days per week for equal to or more than 4 weeks beginning equal to or more than 1 year before admission). Antihistamines studied included chlorpheniramine, doxylamine, triprolidine, brompheniramine, terfenadine, hydroxyzine, diphenhydramine, pyrllamlne, phenyttoxamine, cyproheptadlne, dexbrompheniramine, methapyrilene, astemizole, clemastine, dimethindene, antazoline, promethazlne, pyrrobutamlne, carblnoxamine, pheniramine, dimennydrtnate, tripelennamine, thenyldiamlne, loratadine, trimethobenzamide, pyribenzamine, trimeprazine, and other ones. The cancer risk was calculated according to type and duration of antihistamines. Duration were including less than 1 year, 1–4 years, 5–9 years, and equal to or more than 10 years. The risk of cancer was not associated with the type of antihistamines. In duration of more than 10 years, the risk of cancer was 0.5 (0.95% CI = (0.3–0.8)).
Herpes zoster (shingles) complicating the course of COVID19 infection
Published in Journal of Dermatological Treatment, 2022
Mohamed L. Elsaie, Hesham A. Nada
A lady presented to our attention photographs of her 44 years old male husband complaining of a skin rash on his left upper chest and back. She described the onset to be 24 h earlier with a mild itchy rash (which she kept photographs of) and thought to be an insect bite of no much significance to seek consultation for and for which she applied him an antihistaminic gel (dimethindene maleate) twice daily. She described his pain as stabbing and very painful however not much itchy. Upon his wife’s report, she uncovered that he was diagnosed one week earlier with COVID 19 infection after a chest CT and a confirmatory nasopharyngeal swab. As the patient general condition was good and his oxygen saturation was 96%, he was followed out patiently by his COVID 19 treating consultants and was prescribed (Oseltamivir PO every 12 h, Azithromycin 500 mg PO every day, paracetamol and Vitamin C). Based on self-photographs sent, multiple vesicles and papules spread over an erythematous base were seen, affecting the upper chest and back in a dermatomal pattern. The diagnosis of Hz was made based on the sent photographs and the relevant history and symptoms reported. He was advised to start on valaciclovir 1 g every 8 h and for 7 days along with continuing his other COVID prescribed protocol (Figures 1 and 2).
Analytical investigation of ternary mixture of phenylephrine hydrochloride, dimetindene maleate and benzalkonium chloride using validated stability indicating HPLC-DAD method
Published in Drug Development and Industrial Pharmacy, 2020
Ahmed G. Abdelhamid, Dina S. El-Kafrawy, Magdi M. Abdel-Khalek, Tarek S. Belal
There are many nonprescription (over-the-counter; OTC) medications available on pharmacy shelves marketed for relief of respiratory symptoms. Different combinations of antihistamines and decongestants along with other active ingredients have been widely used in OTC medications taken by adults and children for upper respiratory illnesses such as allergic rhinitis and common cold [1,2]. Nasal preparations containing the direct sympathomimetic agent phenylephrine HCl (PHR) and the highly potent H1 antagonist dimetindene maleate (DMD) are commonly used to relief nasal congestion caused by various conditions including common cold, sinusitis and allergies. These pharmaceutical formulations contain benzalkonium chloride (BZM) as preservative to maintain the microbiological quality of the dosage forms. Chemical structures of the three drugs are shown in Figure 1.