Interactions between Oral Bacteria and Antibacterial Polymer-Based Restorative Materials
Mary Anne S. Melo in Designing Bioactive Polymeric Materials for Restorative Dentistry, 2020
High-molecular-weight dimer acid dimethacrylates (h-DA) derived from the cyclodimerization and hydrogenation of linoleic acid have been developed to address the issues of methacrylate-based materials. h-Da is in a linear and acyclic aliphatic structure that provides for the attainment of monomers with amorphous aliphatic cores and reduced double-bond concentrations per unit volume. Such molecular structure was shown to result in polymer materials with reduced polymerization shrinkage, high degrees of conversion, low glass-transition temperatures, and good flexibility. Also, the aliphatic core’s hydrophobic nature is expected to maximize the long-term chemical and mechanical stability of materials by reducing the hydrolysis of siloxane and ether bonds present in the polymer’s organic matrix.[109]
Pulmonary exposure of mice to ammonium perfluoro(2-methyl-3-oxahexanoate) (GenX) suppresses the innate immune response to carbon black nanoparticles and stimulates lung cell proliferation
Published in Inhalation Toxicology, 2022
Ho Young Lee, Dorothy J. You, Alexia J. Taylor-Just, Keith E. Linder, Hannah M. Atkins, Lauren M. Ralph, Gabriela De la Cruz, James C. Bonner
GenX (Ammonium perfluoro(2-methyl-3-oxahexanoate), molecular formula C6H4F11NO3 (CAS number 62037-80-3) was purchased from Synquest Laboratories (Alachua, FL). The acid form of GenX is also referred to as hexafluoropropylene oxide dimer acid (HFPO-DA) with the molecular formula C6HF11O3. GenX was dissolved in deionized water to achieve the stock concentration of 100 mg/mL. Further dilutions were achieved in phosphate-buffered saline (PBS). A GenX dose of 10 mg/kg body weight delivered to the lungs of mice by oropharyngeal aspiration (OPA) was used in the present study. This dose was within the dose range routinely used for oral gavage (1-100 mg/kg) and 10 times lower than that used in a previous study that investigated GenX exposure using 100 mg/kg by oral gavage (Rushing et al. 2017).
Tailoring the monomers to overcome the shortcomings of current dental resin composites – review
Published in Biomaterial Investigations in Dentistry, 2023
Jingwei He, Lippo Lassila, Sufyan Garoushi, Pekka Vallittu
Dimer acid dimethacrylate (as shown in Figure 2) is one kind of monomer with high molecular weight but low viscosity. In photopolymerization, dimer acid dimethacrylate showed a high degree of conversion coupled with low volumetric shrinkage and nearly negligible water sorption and is considered a good alternative to Bis-GMA [39]. NĭDurance is one kind of commercial DRCs containing dimer acid dimethacrylate, UDMA (bis-[(2-methacryloyloxy-ethoxycarbonyl)amino]-2,2,4-trimethylhexane), and Bis-EMA (Ethoxylated bisphenol A dimethacrylate). However, NĭDurance has been reported to have higher volumetric shrinkage than Bis-GMA-based commercial DRCs [40].
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