Fats and Cardiovascular Disease
Stephen T. Sinatra, Mark C. Houston in Nutritional and Integrative Strategies in Cardiovascular Medicine, 2015
Statins, even at low doses, have anti-inflammatory effects. This may be the real value of statin treatment, not the lowering of cholesterol. Coenzyme Q10 (CoQ10) is also lowered by statins. CoQ10 is necessary for the electron transport system in mitochondria. Coenzyme Q10 is a compound made by all the cells in our bodies. All the body cells can make it and it is used to produce energy for all the necessary functions of the cells. It is essential for the cells ability to make ATP (adenosine triphosphate), the main energy currency of all the cells. The ATP is found in all cells and usually is in the mitochondria associated with the electron transport system that converts the food we eat to usable energy for growth and maintenance. It also acts as an antioxidant to protect the body from oxidative damage. Statins inhibit the production of CoQ10 and may be the main cause of the bad side effects people often experience when taking statin drugs.
Kearns–Sayre syndrome
William L. Nyhan, Georg F. Hoffmann, Aida I. Al-Aqeel, Bruce A. Barshop in Atlas of Inherited Metabolic Diseases, 2020
Coenzyme Q10 may be of benefit. Treatment with 60–120 mg daily was reported [39] to be associated with decrease in modestly elevated levels of lactic and pyruvic acids and improvement in the prolongation of the PQ interval on the ECG, as well as ocular movements. The QRS complex did not change. Concentrations of folic acid and of carnitine may be reduced in plasma or muscle, and treatment with these agents may be useful. A vitamin B complex supplement is often prescribed. Two patients with cerebral folate deficiency were successfully treated with folic or folinic acid [7, 39]. In one [7] treatment with folinic acid at 2.5 mg/kg/day led to ambulation with ataxic gait in a patient who had lost the ability to walk. After one year of treatment, the 5-MTHF in the CSF was normal. Cranial MRI revealed improved myelination.
Lifestyle and Diet
Chuong Pham-Huy, Bruno Pham Huy in Food and Lifestyle in Health and Disease, 2022
Poultry meat from chicken, duck, turkey, and goose is good food because it is not high in energy, but is rich in digestible proteins, and low in saturated or bad fats. In addition, it contains many vitamins of B-group, and minerals, especially zinc, selenium and copper and alpha-linoleic acid (ALA), a precursor of omega-3 unsaturated fatty acid. Poultry meat is suitable for overweight and obese people and the elderly. Poultry meat may also prevent cardiovascular diseases and Type 2 diabetes mellitus (35). Moreover, it is cheaper than beef, pork, and fish. However, poultry skin is richer in saturated fats or bad fats than poultry meat. So, discard poultry skin when consuming poultry meat. Besides meat, some organs of mammals (beef, pork) and poultry such as liver, heart, kidney, and stomach are edible and delicious. The levels of some nutrients such as coenzyme Q10 from these organs are found higher than those in corresponding meats. Coenzyme Q10, present in liver and heart of beef and pork, is more active than its synthetic supplement. It is a nutrient necessary for elderly people because its production in the human body decreases with age. Coenzyme Q10 is necessary for the activity of muscle, especially for heart activity.
Nutrition in the management of type 2 diabetes mellitus: review
Published in Archives of Physiology and Biochemistry, 2021
Walid Hamdy El-Tantawy
Coenzyme Q10 (CoQ10) is produced endogenously, and also known as ubiquinone. It possesses a 10-carbon side chain and is similar in structure to vitamin K. It has an antioxidant activity that may increase adenosine triphosphate production, scavenges oxygen free radicals, and stabilise membranes (Saini 2011). It has been shown to have a statistically significant benefit in glucose control in 74 patients with T2DM when combined with fenofibrate (HbA1C decreased significantly from 7.5 to 7.2% (Hodgson et al.2002). Another small trial in nine patients with T2DM showed that CoQ10treatment decreased HbA1C from 7.1 to 6.8% (p = .03) (Mezawa et al.2012). A recent study has shown that CoQ10 supplementation may reduce hyperglycaemia due to diminished levels of GLUT-4 (Ganesan and Ito 2013).
Clinical profiles and risk assessment in patients with antiphospholipid antibodies
Published in Expert Review of Clinical Immunology, 2019
Masaru Kato, Ryo Hisada, Tatsuya Atsumi
Coenzyme Q10 is a member of the mitochondrial respiratory chain that plays an important role in preventing mitochondrial disruption and oxidative stress, with some beneficial effects of its supplementation on cardiovascular disease [80]. A randomized, placebo-controlled trial involving 36 patients with APS showed an improvement of endothelial function and a decrease of prothrombotic and proinflammatory mediators in monocytes following the supplementation of coenzyme Q10 [81]. Furthermore, coenzyme Q10 prevented the formation of neutrophil extracellular traps in ex vivo cultured neutrophils of patients with APS [81]. Because of the absence of clinically significant side effects, coenzyme Q10 might act as safe adjunct not only to standard therapies in patients with APS but also to primary thrombosis prophylaxis in asymptomatic aPL carriers.
The effects of coenzyme Q10 supplementation on gene expression related to insulin, lipid and inflammation in patients with polycystic ovary syndrome
Published in Gynecological Endocrinology, 2018
Elham Rahmani, Mehri Jamilian, Mansooreh Samimi, Maryam Zarezade Mehrizi, Esmat Aghadavod, Elmira Akbari, Omid Reza Tamtaji, Zatollah Asemi
Coenzyme Q10 (CoQ10) is a nutrient that plays an important function in the production of cellular energy as well as acts in scavenging free radicals and inhibiting lipid and protein oxidation as an antioxidant [5]. Previously, beneficial effects of CoQ10 on gene expression related to insulin, lipid and inflammation among subjects without PCOS have evaluated. Tarry-Adkins et al. [6] found that postweaning dietary intake of recuperated animals with CoQ10 prevented the programed reduction in insulin receptorsubstrate-1 and p110-β and the programed increased in IL-6. In addition, in another study was seen that CoQ10 administration at a dosage of 20 mg/kg increased insulin sensitivity and had antidiabetic properties via increasing activity of phosphatidylinositol kinase (PI3K) in rats fed a high-fat, high-fructose diet [7]. Mediterranean diet with CoQ10 also modified gene expression of pro-inflammatory markers among elderly men and women for four weeks [8].
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