Clebopride

Clebopride

Effects of Dopamine on The Digestive System

Published in M.D. Francesco Amenta, Peripheral Dopamine Pathophysiology, 2019

In conscious guinea pigs, subcutaneous apomorphine (0.1 to 0.5 mg/kg) caused a dose-dependent decrease in gastric emptying of barium sulphate spheroids, measured by X-ray fluoroscopy.37 Intracerebroventricular (i.e.v.) administration of apomorphine (100 to 200 μg) induced similar reduction of gastric emptying. The inhibitory effect of subcutaneous and i.c.v. apomorphine was antagonized by haloperidol, domperidone, ( —)-sulpiride, metoclopramide, and clebopride (administered intraperitoneally vs. subcutaneous apomorphine, i.c.v. vs. i.c.v. apomorphine); intraperitoneal injection of prazosin plus propranolol did not influence the effect of apomorphine. It was concluded that the DA receptor agonist apomorphine reduces gastric emptying, possibly via central dopaminergic mechanisms.37

Current and emerging therapeutic options for the management of functional dyspepsia

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Journal Information

Published in Expert Opinion on Pharmacotherapy, 2020

A. Vandenberghe, J. Schol, K. Van den Houte, I. Masuy, F. Carbone, J. Tack

Clebopride is a D2-receptor antagonist from the same chemical family as metoclopramide. It is used in gastrointestinal functional disorders for its antiemetic and prokinetic properties. However, a small study conducted in Spain identified a higher number of extrapyramidal symptoms with clebopride compared to metoclopramide [32,38]. Clebopride is free of cardiac side-effects at the prescribed dose [39]. The drug is available in Italy, Portugal, Spain, Pakistan, Bangladesh, and Indonesia. In some countries, clebopride is associated with simethicone in a single tablet.

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Effects of Dopamine on The Digestive System

Current and emerging therapeutic options for the management of functional dyspepsia