Management of poisoning
Bev-Lorraine True, Robert H. Dreisbach in Dreisbach’s HANDBOOK of POISONING, 2001
Transaminase values are elevated, but alkaline phosphatase is low. Depending on the extent of damage, this type of injury may not be reversible. Direct hepatotoxic effects (single dose, effect immediate, all individuals susceptible) – acetaminophen, Amanita phalloides, arsenic, carbon tetrachloride, chloroform, phosphorus, stilbamidine, tannic acid, tetracyclines.Delayed hepatotoxic effect (long exposure, all individuals susceptible) – Ethanol.Hepatitis reactions (sporadic, possible idiosyncrasy, response delayed) – chloramphenicol, Chlortetracycline, cinchophen, gold salts, halothane, iproniazid, isoniazid, methoxyflurane, novobiocin, penicillins, phenylbutazone, pyrazinamide, streptomycin, sulfamethoxypyridazine, trinitrotoluene, zoxazolamine, valproate.Chronic hepatitis reactions (slow onset, prolonged or repeated exposure) – acetaminophen, aspirin, chlorpromazine, halothane, isoniazid, methyldopa, nitrofurantoin, oxyphenisatin.
A patent review of transient receptor potential vanilloid type 1 modulators (2014–present)
Published in Expert Opinion on Therapeutic Patents, 2021
Mengkang Gao, Yusui Wang, Lanqi Liu, Zhenrui Qiao, Lin Yan
China Pharmaceutical University has patented derivatives containing phenylquinoline as TRPV1 antagonists, which have the general structures of S15 are shown in Table 4 [33]. The representative compounds of the patent and their biological activity data are shown in Table 10. The phenylquinoline derivatives reported in the patent were spliced from part of the structure of the traditional analgesic drug cinchophen and piperazine formamide analogues, and had good TRPV1 inhibitory activity. The activities of some compounds were much higher than that of the traditional painkiller cinchophen and the classic TRPV1 antagonist BCTC, and there were almost no side effects of hepatotoxicity, gastric mucosal injury, and hyperthermia. Through pharmacological experiments such as foot licking test, writhing test, tail contraction test, acute hepatotoxicity risk assessment, gastric mucosal injury test, body temperature test in mice and so on, dominant compounds 73, 74, 75, 76, 77, 78, and 79 were screened. The inhibition rates of these compounds on TRPV1 were all more than 50%, and the levels of glutamic pyruvic transaminase and glutamic oxaloacetic transaminase of compounds 77 and 79 were not significantly different from those of the blank group, and the risk of hepatotoxicity was significantly lower than that of cinchophen. In particular, the analgesic activity of compound 79 was not only better than BCTC but also had no significant effect on gastric mucosa and body temperature in mice.
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