Introduction
Brijesh Kumar, Vikas Bajpai, Vikaskumar Gond, Subhashis Pal, Naibedya Chattopadhyay in Phytochemistry of Plants of Genus Cassia, 2021
Traditionally, the leaves of Cassia species are popular as potherb. It is used as a natural pesticide in the organic farms of India. It has been reported that Cassia species contain chrysophanic acid-9-anthrone which is an important fungicide. The intake of these seeds can cure skin diseases like ringworm, itch and psoriasis. These herbal seeds can also remove intense heat from the liver and improve the acuity of sight and loosen the bowels to relieve constipation. The leaves contain anthraquinones and are employed in weak decoction for treating childhood teething, fever and constipation. The paste of the ground, dried root is used in Ayurveda to treat ringworm and snakebite (Shivjeet et al., 2013).
Catalog of Herbs
James A. Duke in Handbook of Medicinal Herbs, 2018
Toxicity — Powder (or sawdust) is to be avoided as it inflames the mucous membranes. Dangerous for the eyes.33 Internally, 200 mg can produce diarrhea, nausea, and nephritis.33 Goa powder is irritant to the respiratory tract.6 In industrial accidents, chrysophanic acid has produced conjunctivitis and keratitis.6
Rhubarb
Mahendra Rai, Shandesh Bhattarai, Chistiane M. Feitosa in Ethnopharmacology of Wild Plants, 2021
Chrysophanol (1) possesses antibacterial and spasmolytic activities (Khetwal and Pathak 1988, Coopoosamy and Magwa 2006). It protects brain tissue damage during cerebral ischemia/reperfusion by inhibiting NALP3 inflammasome and could protect cerebral ischemic stroke (Zhang et al. 2014).
Anthraquinones from Aloe spp. inhibit Cryptococcus neoformans sensu stricto: effects against growing and mature biofilms
Published in Biofouling, 2021
Débora de Souza Collares Maia Castelo-Branco, Géssica dos Santos Araújo, Xhaulla Maria Quariguasi Cunha Fonseca, Glaucia Morgana de Melo Guedes, Maria Gleiciane da Rocha, Raimunda Sâmia Nogueira Brilhante, Rossana de Aguiar Cordeiro, José Júlio Costa Sidrim, Waldemiro Aquino Pereira-Neto, Marcos Fábio Gadelha Rocha
Anthraquinones form the largest class of secondary metabolites extracted from Aloe spp. and include aloe emodin, barbaloin and chrysophanol (Salehi et al. 2018; Sánchez et al. 2020). Aloe emodin is a phytochemical with anti-inflammatory, antitumor and antimicrobial activity (Dong et al. 2020; Chen et al. 2020; Jiang et al. 2019; Jiang et al. 2020; Ma et al. 2020). Barbaloin, structurally similar to aloe emodin, also has antimicrobial activity, in addition to neuroprotective and nephroprotective effects (Lee et al. 2019; Donkor et al. 2020; Jing et al. 2020). Furthermore, chrysophanol (1,8-dihydroxy-3-methylanthraquinone) has antibacterial, anti-tumor and antidiabetic activities (Lee and Sohn 2008; Xie et al. 2019; Su et al. 2020).
Anti-hyperglycemic and genotoxic studies of 1-O-methyl chrysophanol, a new anthraquinone isolated from Amycolatopsis thermoflava strain SFMA-103
Published in Drug and Chemical Toxicology, 2021
Cheemalamarri Chandrasekhar, Hemshikha Rajpurohit, Kalpana Javaji, Madhusudana Kuncha, Aravind Setti, A. Zehra Ali, Ashok K. Tiwari, Sunil Misra, C. Ganesh Kumar
The purity of OMC isolated from strain SFMA-103 was confirmed by reverse phase chromatography using Agilent reverse phase column C18 column (4.6 × 250 mm, 5 μm) interfaced to an Agilent 1200 HPLC system (Agilent Technologies, CA). The mobile phase used was HPLC grade solvents of methanol-H2O (60:40; v/v). OMC was detected using diode array detector (DAD) at a wavelength of 254 nm with flow rate of 1 mL/min at room temperature (Tan et al.2011). Chrysophanic acid (CAS No. 481–74-3, TCI Chemicals Pvt. Ltd. India) was used as a standard.
Cellular Calcium Signals in Cancer Chemoprevention and Chemotherapy by Phytochemicals
Published in Nutrition and Cancer, 2022
Xue Li, Shuhan Miao, Feng Li, Fen Ye, Guang Yue, Rongzhu Lu, Haijun Shen, Yang Ye
Chrysophanol (1,8-dihydroxy-3-methyl-9,10-anthraquinone) is a plant-derived anthraquinone compound typically obtained from Rhubarb (133, 134) with anti-inflammatory, anti-angiogenic and anticancer activities (135). Chrysophanol induces apoptosis and inhibits invasiveness in ovarian cancer cells through regulating mitochondrial calcium overload. Chrysophanol-induced mitochondrial calcium overload is mainly from the disruption of MMP and upregulation of the MAPK signaling pathway, resulting in cell death (136).
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