Role of Nutraceuticals in Prevention of Nonalcoholic Fatty Liver
Megh R. Goyal, Durgesh Nandini Chauhan in Plant- and Marine-Based Phytochemicals for Human Health, 2018
Investigation of the therapeutic effect of caffeic acid and chlorogenic acid toward fatty liver in mice fed high-fat diet showed promising reduc- tion in body weight, visceral fat mass and liver, heart, adipose tissue, and plasma triglycerides. Both phenolic acids reduced cholesterol content in plasma, adipose tissue, and heart. Chlorogenic acid supplementation produced an increase in plasma adiponectin, which could indicate its anti- inflammatory effect. The mechanism underlying the effect of caffeic and chlorogenic acids was ascribed to their significant inhibition of fatty acid synthase, enhancement of fatty acids beta-oxidation, and increased PPAR alpha expression in liver.23 Caffeic acid is present in tea, pear, basil, thyme, and apple, whereas chlorogenic acid is present in fruits, green tea, and green coffee bean.
Consumption of Foods, Food Groups, and Cardiometabolic Risk
Nathalie Bergeron, Patty W. Siri-Tarino, George A. Bray, Ronald M. Krauss in Nutrition and Cardiometabolic Health, 2017
Several clinical studies have suggested important roles for polyphenols and antioxidants, similar to those found in fruits and vegetables. Findings from randomized trials indicate that improved adipocyte and hepatocyte function induced by changes in adiponectin and fetuin-A concentrations may play a role in the benefit of coffee (Wedick et al. 2011). Coffee also appears to improve markers of inflammation and endothelial dysfunction, such as TNF-α, E-selectin, C-reactive protein, and VCAM-1 (Kempf et al. 2010, Natella and Scaccini 2012). The presence of phytochemicals in coffee such as flavonoids, lignans, and chlorogenic acid has also been observed to independently increase glucose tolerance and insulin sensitivity (Natella and Scaccini 2012, van Dijk et al. 2009). Chlorogenic acid in particular has recently caught the attention of researchers, as it appears to reduce fasting glucose (Rodriguez de Sotillo et al. 2006), increase insulin sensitivity (Shearer et al. 2003), and attenuate the appearance of glucose in blood after challenging with glucose (Bassoli et al. 2008).
Bioactive Compounds in Coffee: Health Benefits of Macronutrients and Micronutrients
Megh R. Goyal, Durgesh Nandini Chauhan in Assessment of Medicinal Plants for Human Health, 2020
Polyphenols are available in a variety of plants including coffee.16 Polyphenol structures consist of hydroxyl groups and aromatic rings.32 Chlorogenic acid reduces hepatic triglyceride levels. Chlorogenic acid inhibits glucose-6-hepatic-phosphatase (G6PD) thus limiting the enzyme related to gluconeogenesis.19 Roasting the coffee will reduce the chlorogenic acid percentage in coffee. Green coffee beans are rich in chlorogenic acid and are linked to the effects of hypotension, beneficial increase of fat metabolism in the liver. The research studies on coffee beans using the sesamin and orlistat reagents as reference compounds showed better fat reduction if the provision of coffee drink is in the form of whole food, rather than the form of active substances such as chlorogenic acid or caffeine alone because chlorogenic acid will increase the metabolism of fat in the liver.37 In addition, the effect of increased blood pressure from caffeine will be more influential when caffeine is consumed alone.12
Protective effects of Re-yan-ning mixture on Streptococcus pneumonia in rats based on network pharmacology
Published in Pharmaceutical Biology, 2021
Lizhu Han, Jing Kou, Kunxia Hu, Yunlan Wang, Zhishu Tang, Zhisheng Wu, Xiao Song
Of these components, chlorogenic acid, which is a polyphenolic natural compound, is commonly found in apples, coffee beans, grapes, pulp, peels and tea. It is structurally a depsipeptide produced from caffeic acid and quinic acid. It is reported that it has a number of health benefits, including antibacterial, antiviral, antitumor, increases white blood cells, blood pressure activity, blood lipid activity, scavenges free radicals, central nervous system excitation and other biological activities (Hua et al. 2008). Chlorogenic acid has bacteriostatic effects on Gram positive bacteria (Staphylococcus aureus, Bacillus subtilis) and Gram negative bacteria (Shigella, Escherichia coli, Salmonella typhi). It has the strongest inhibitory effect on Streptococcus pneumonia and Shigella (Lou et al. 2011). Chlorogenic acid may induce the immediate and massive release of K+ from Shigella and Streptococcus pneumonia by increasing the permeability of the plasma membrane, which may cause significant nucleotide leakage (Yang et al. 2012).
Deciphering the anti-filarial potential of bioactive compounds from Ocimum sanctum: a combined experimental and computational study
Published in Pharmaceutical Biology, 2022
Ayushi Mishra, Vipin Kumar, Anchal Singh
To further investigate the stability of interactions between eight OS bioactive compounds and filarial antioxidant enzymes/proteins we performed molecular dynamics simulation. The simulation data obtained in this study clearly shows that OS bioactive compounds remained bound to the proteins throughout the run suggesting that these complexes are well stabilized. Ursolic acid, chlorogenic acid, and luteolin were most stable during the simulation run showing the lowest RMSD and RMSF values. Ursolic acid (UA) has preventive and curative properties against many diseases affecting the liver and brain, and also in cancers and metabolic syndromes etc. (Seo et al. 2018). UA has been found to be effective against B. malayi GST in a previous study (Kalani et al. 2014). Luteolin has antioxidant properties and has shown potential as anti-inflammatory agent in a gut inflammation model (Mizuno and Nishitani 2013). Chlorogenic acid is an important bioactive polyphenol and many studies confirm it as antidiabetic, anti-obesity, anti-tumor, neuro protector, hepatoprotective, antioxidant, and anti-inflammatory activity (Tajik et al. 2017). Therefore, the combined results of these ex vivo and in silico studies with OS and its bioactive compounds strongly indicate towards their anti-filarial potential which should be explored further for developing adulticidal filarial drugs.
Characterization of potentially health-promoting constituents in sea fennel (Crithmum maritimum) cultivated in the Conero Natural Park (Marche region, Central Italy)
Published in Pharmaceutical Biology, 2023
Antonietta Maoloni, Teresa Pirker, Eva-Maria Pferschy-Wenzig, Lucia Aquilanti, Rudolf Bauer
As far as the semiquantitative determination of hydroxycinnamic acid derivatives and flavonoids is concerned, the lower concentration detected in stems than in leaves and the presence of chlorogenic acid as the most concentrated polyphenol are in agreement with previous studies by Pereira et al. (2017) and Meot-Duros and Magné (2009), respectively. Furthermore, the results herein collected agree with available data related to sea fennel growing in different geographical areas. In more detail, concentrations of chlorogenic acid of 0.64 g/100 g DW (Nabet et al. 2017), 0.73 g/100 g DW (Souid et al. 2021), and between 0.56 and 1.63 g/100 g DW (Generalić Mekinić et al. 2018) were reported in sea fennel harvested in Algeria, France, and Croatia, respectively. Chlorogenic acid is a hydroxycinnamic acid described in literature as one of the most widely distributed and functional polyphenols in the human diet, displaying health beneficial effects, behaving as antioxidant, anti-inflammatory, antimicrobial, antimutagenic, cardiovascular protective, neuroprotective, renoprotective, gastrointestinal tract-protective and hepatoprotective agent, and modulating lipid and glucose metabolism (Naveed et al. 2018; Lu et al. 2020).
Related Knowledge Centers
- Caffeic Acid
- Ester
- Ferulic Acid
- Lignin
- Polyphenol
- Quinic Acid
- P-Coumaric Acid
- Chlorine
- Redox
- Neochlorogenic Acid