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Published in Caroline Ashley, Aileen Dunleavy, John Cunningham, The Renal Drug Handbook, 2018
Caroline Ashley, Aileen Dunleavy, John Cunningham
After oral administration cefuroxime axetil is rapidly hydrolysed in the intestinal mucosa and blood to release active cefuroxime. Cefuroxime is excreted unchanged in the urine, 50% by glomerular filtration and 50% by renal tubular secretion. Probenecid competes for renal tubular secretion with cefuroxime resulting in higher and more prolonged plasma concentrations of cefuroxime. Small amounts of cefuroxime are excreted in bile.
Cefuroxime
Published in M. Lindsay Grayson, Sara E. Cosgrove, Suzanne M. Crowe, M. Lindsay Grayson, William Hope, James S. McCarthy, John Mills, Johan W. Mouton, David L. Paterson, Kucers’ The Use of Antibiotics, 2017
Cefuroxime axetil, an ester of the drug, is suitable for oral administration. This compound is formulated as an ester prodrug to facilitate its absorption. Its molecular formula is C20H22N4O10S, and its molecular weight is 510.48. The structural formula is illustrated in Figure 22.2.
Cephalosporins
Published in Thomas T. Yoshikawa, Shobita Rajagopalan, Antibiotic Therapy for Geriatric Patients, 2005
There is, in general, limited use for the second-generation oral cephalosporins in the elderly. Cefuroxime axetil can be used for mild to moderate community-acquired respiratory or SSTI; it should not be used for UTIs in the elderly unless there is no alternative. Cefaclor is similar to cephalexin in its pharmacokinetics but has somewhat improved activity against H. influenzae, M. catarrhalis, P. mirabilis, and E. coli and is available in generic form. Its indications are similar to cefuroxime axetil, although overall it is an inferior drug in antimicrobial activity and pharmacokinetics. However, in all cases, more effective and less expensive alternatives are available to either of these oral cephalosporins.
The effectiveness of the dacryocystorhinostomy operation with physiodispenser in nasolacrimal duct obstruction
Published in Orbit, 2022
Fikret Ucar, Servet Cetinkaya, Lutfi Seyrek
Post the operation, all the patients were recommended to use the oral antibiotic tablet Cefuroxime axetil 500 mg (Cefaks, Deva, Turkey) twice a day for one week and a combination of antibiotic and steroid eye drops Moxifloxacin + Dexamethasone 5 mg/1 mg (Moxidexa, Abdi Ibrahim, Turkey) four times a day for two weeks. Follow-up examinations were performed in the first, third, and sixth post-operative months and the first and second post-operative years. Nasolacrimal irrigation was performed during every follow-up examination. Silicone tubes were removed in the third post-operative month. The openness of the nasolacrimal duct with irrigation was accepted as an anatomic success, and the lack of epiphora was accepted as a functional success.
Preparation and optimization of multi-functional directly compressible excipient: an integrated approach of principal component analysis and design of experiments
Published in Drug Development and Industrial Pharmacy, 2020
Dhaval Mori, Punit Rathod, Ramesh Parmar, Kiran Dudhat, Jayant Chavda
Cefuroxime axetil – the selected model drug is a second-generation semi-synthetic cephalosporin antibiotic. It has poor flowability and compressibility [17]. It is currently marketed in the form of tablets (125, 250, and 500 mg) and dry suspension (125 or 250 mg/5 ml). The presence of the β-lactam ring makes cefuroxime axetil prone to get hydrolyzed in the presence of water and thus leaving it ineffective against targeted microorganisms. Due to water sensitivity, wet granulation cannot be used to prepare cefuroxime axetil tablets so in most cases either dry granulation or direct compression methods are used to prepare the tablets [18].
Co-processing of cefuroxime axetil by spray drying technique for improving compressibility and flow property
Published in Drug Development and Industrial Pharmacy, 2019
Punit Rathod, Dhaval Mori, Ramesh Parmar, Moinuddin Soniwala, Jayant Chavda
Cefuroxime axetil was received from the Bharat parenterals limited, Vadodara, Gujarat, India as a gift sample. Acetone, isopropyl alcohol (IPA), chitosan chlorhydrate and mannitol were procured from SD fine chemicals, Ahmedabad, Gujarat India. All other excipients used were of laboratory grade.