Cefodizime Today and Tomorrow: Results and Promises
M. T. Labro in Host Defense and Infection, 1994
Many points need further evaluation to better assess the IRM activity of cefodizime in infectious diseases: The precise mechanism underlying the observed effects is not yet understood. The possible stimulating effect on the release of “cytokine” (?) or other factor(s) has not been fully explored and the “mediator(s)” involved (if any) are yet undefined.The chronobiology-dependent activity of cefodizime shown in some models has not been taken into account in most experimental studies, and this may explain some controversial results. As stressed previously, this research area is be-
Research on the relationship between cephalosporin structure, solution clarity, and rubber closure compatibility using volatile components profile of butyl rubber closures
Published in Drug Development and Industrial Pharmacy, 2019
Xiao-Meng Chong, Xin Dong, Shang-Chen Yao, Chang-Qin Hu
All kinds of cephalosporins for injection were obtained from national evaluation inspection in China. Except for some samples that did not meet the requirement for clarity of reconstituted solutions provided in Chinese Pharmacopoeia, all the other items qualified. The cephalosporins for injection included seven batches of cefodizime sodium for injection from one manufacturer. Among the seven batches, the clarity of three batches did not meet the requirement of clarity of solution provided in Chinese Pharmacopoeia. Among the six batches of ceftriaxone sodium for injection from two different manufacturers, the clarity of three batches did not meet the requirement of clarity of solution provided in Chinese Pharmacopoeia. Although the clarity of seventeen batches of cefpiramide sodium for injection from six different manufacturers met the requirement of clarity of solution, the extent of turbidity of each batch was different when measured with a nephelometer. The clarity of all four batches of cefamandole nafate for injection from two different manufacturers met the requirement of clarity of solution; however, the extent of turbidity of each batch was different when measured with a nephelometer. The clarity of one batch of cefmenoxime for injection and one batch of cefoperazone sodium for injection met the requirement of clarity of solution.
Related Knowledge Centers
- Cephalosporin
- Enterobacteriaceae
- Escherichia Coli
- Klebsiella Pneumoniae
- Proteus Mirabilis
- Salmonella
- Yersinia Enterocolitica
- Broad-Spectrum Antibiotic
- Morganella Morganii
- Shigella Sonnei