Biobased Products for Viral Diseases
Mahendra Rai, Chistiane M. Feitosa in Eco-Friendly Biobased Products Used in Microbial Diseases, 2022
New bioactive peptides, demonstrating anti-viral activity for dengue, isolated from 33 Thai medicinal plants, were identified (Panya et al. 2019). Among the tested extracts, Acacia catechu L. peptides showed the most pronounced anti-DENV activity. A. catechu L. is a legume species of the genus Acacia, belonging to the Fabaceae family, an Asian medicinal plant, whose seeds are a good source of protein. Two bioactive peptides isolated from A. catechu L. inhibited the formation of DENV foci by more than 90%. The authors reported that the two peptides are recommended for further investigation as antivirals against DENV infection. The extract of the Asian medicinal plant Houttuynia cordata T., known as fish mint, prevented dengue virus infectivity (Xie et al. 2013; Chiow et al. 2016).
Abies Spectabilis (D. Don) G. Don (Syn. A. Webbiana Lindl.) Family: Coniferae
L.D. Kapoor in Handbook of Ayurvedic Medicinal Plants, 2017
Pharmacognostical characteristics — A. catechu is a moderate-sized tree. Its dark grayishbrown bark is nearly ½, in. in thickness, exfoliating in long, narrow strips, brown or red inside. The most important products obtained from A. catechu is catechu. This is obtained by boiling the heartwood with water. As sold in the market, katha is found in irregular pieces or small square blocks of grayish color, which after breaking show crystalline fracture.
Catechin Metabolites along with Curcumin Inhibit Proliferation and Induce Apoptosis in Cervical Cancer Cells by Regulating VEGF Expression In-Vitro
Published in Nutrition and Cancer, 2022
Elnaz Khojaste, Changiz Ahmadizadeh
Catechin is a plant-derived phenolic secondary metabolite that has been derived from catechu (the tannic juice or boiled extract of Mimosa catechu). Catechins are found in green tea more than black tea. Polyphenolic catechins are the most common antioxidants that play an important role in preventing diseases such as cancers by preventing the formation of radicals which in turn leads to free radical-induced tissue damage (6). As discovered, EGCG, EGC, and ECG are the most important metabolites of catechins, which are produced by metabolisms exerted on green tea in the gut by intestinal microbiota (7). The bioavailability of catechins in humans is less than 4%, so intact tea catechins are not absorbed by the body. Besides, these substances are metabolized by the intestinal microbiota after reaching the large intestine. Therefore, the intestinal microbiota plays a vital role in the production of catechin metabolites and increasing their bioavailability. Many barriers can interrupt the production, absorption, and bioavailability of catechin metabolites, most of which are chemical degradation, liver metabolism, intestinal microbiota composition, and membrane permeability (8). It was determined in a study that fecal-derived catechin metabolites that are produced by intestinal microbiota, have been involved in regulating cancer pathogenesis (9, 10).
Areca nut procyanidins prevent ultraviolet light B-induced photoaging via suppression of cyclooxygenase-2 and matrix metalloproteinases in mouse skin
Published in Drug and Chemical Toxicology, 2022
Chia-Ling Weng, Chih-Chiang Chen, Han-Hsing Tsou, Tsung-Yun Liu, Hsiang-Tsui Wang
The extraction was modified from our previous studies (Huang et al.2010). Briefly, fresh tender areca nuts, the fruit of Areca catechu, were purchased from local shops in Taipei, Taiwan. After removing the husks, the nuts were extracted three times with 80% acetone (1:10 w/v). The acetone was then removed using a vacuum evaporator (Buchi Re111, Switzerland) under reduced pressure. The aqueous residue was subsequently partitioned with n-hexane and ethyl ether to remove lipid materials. After lyophilizing the aqueous layer, the resulting light-yellow powder was used as the areca nut extract (ANE) and kept at −20 °C under argon. Our previous studies have shown that ANE contained catechin-based procyanidins, which ranged from dimers to decamers and polymers, using HPLC and electrospray ionization-mass spectrometry (ESI-MS) (Huang et al.2010). Therefore, we refer to the extract as ANPs throughout and two doses of ANP (10 and 20 mg/kg/d) were used in the UVB-induced photoaging mouse model according to our previous studies showing antioxidant capacity and anti-inflammatory potential of ANPs (Huang et al.2010).