Preclinical Antidepressant-Like Effects of Terpenes, Polyphenolics, and Other Non-Flavonoid Phytochemicals
Scott Mendelson in Herbal Treatment of Major Depression, 2019
3-n-Butylphthalide is one of the chemical constituents of celery oil. It had an antidepressant-like effect in rats that had been subjected to two weeks of injections of the inflammatory agent lipopolysaccharide. 3-n-Butylphthalide inhibited expression of pro-inflammatory cytokines, including IL-1β and IL-6, and downregulated the NF-κB signal pathway. It also dampened reduced lipopolysaccharide-induced oxidative reactions in the hippocampus and enhanced Nrf2-targeted signals.31 In the mouse model of Alzheimer’s disease, 3-n-butylphthalide activated the PI3K/AKT pathway, increased BDNF levels, and stimulated TrkB. All of these effects are strongly associated with antidepressant effects.32
Apiaceae Plants Growing in the East
Mahendra Rai, Shandesh Bhattarai, Chistiane M. Feitosa in Ethnopharmacology of Wild Plants, 2021
The leaf extract of A. graveolens decreased systolic blood pressure and lipid parameters and increased the heart rate in fructose-induced and deoxycorticosterone acetate-induced hypertensive rats (Moghadam et al. 2013, Dianat et al. 2015). Interestingly, no effect on blood pressure or heart rate was observed in normotensive rats. One of the major components of celery fruit oil, 3-n-butylphthalide, displayed antihypertensive and vasorelaxant activity (Sowbhagya 2014). Accordingly, celery can be considered as a potential herbal treatment for chronic hypertension in humans.
Effects of butylphthalide injection on treatment of transient ischemic attack as shown by diffusion-weighted magnetic resonance imaging abnormality
Published in International Journal of Neuroscience, 2020
Chenhao Zhang, Yanjing Zang, Qin Song, Weidong Zhao, Hongxuan Li, Lei Hu, Qing Zhang, Fang Gu, Chunliang Zhang
In the clinical setting, the importance of patients with TIA and abnormal DWI should be emphasized. Intervention should be performed, endothelial integrity should be protected and the collateral circulation should be established as soon as possible to reduce the risk of cerebral infarction. Butylphthalide (dl-3-n-butylphthalide) is an effective component, which is separated from celery seeds. Butylphthalide exert neuroprotective effects in the treatment against ischemic stroke through anti-oxidant, antiinflammation, anti-apoptosis, anti-thrombosis and protection of mitochondria [28,29]. Butylphthalide soft capsules can effectively improve the neurological deficits in patients after cerebral ischemia, infarction, which have fewer adverse reactions and high safety [15,16]. Previous studies [17,30,31,32] showed that butylphthalide promoted the expressions of VEGF and bFGF in patients with acute cerebral infarction (ACI), and increased the circulating level of endothelial progenitor cells (EPCs), which improved patients’ prognosis and their short-term outcomes following ACI. A randomized controlled trial showed that 90-day treatment with dl-3n-butylphthalide could improve outcomes at the third month after stroke and intravenous and oral administrations were both safe [33].
Difference and alteration in pharmacokinetic and metabolic characteristics of low-solubility natural medicines
Published in Drug Metabolism Reviews, 2018
Shenglei Yan, Yuying Liu, Jianfang Feng, Hua Zhao, Zhongshu Yu, Jing Zhao, Yao Li, Jingqing Zhang
(4) Active parental drugs are metabolized to toxic metabolites. Butylphthalide (an ester) is metabolized to 3-N-acetylcysteine-butylphthalide with moderate hepatotoxicity (Diao et al. 2014). 6-OH paclitaxel induces myelosuppression (Kang et al. 2001).
Related Knowledge Centers
- Brain Ischemia
- Celery
- Neuroprotection
- Hypertension
- Sedanolide
- Appropriate Use Criteria