Role of Naturopathy in Pain Management
Mark V. Boswell, B. Eliot Cole in Weiner's Pain Management, 2005
In France, there are many more pharmacologic preparations classified as vasodilatory than are available in the United States. The drug of this class that is most frequently used in France is buflomedil (Fonzylane). The only FDA-approved medication in the United States that is used in France that resembles this category is pentoxifylline (Trental). Pentoxifylline, approved for the treatment of intermittent claudication, improves the flow properties of blood by decreasing its viscosity and improving erythrocyte flexibility, thereby enhancing tissue oxygenation. Pentoxifylline has been shown to increase leukocyte deformability and to inhibit neutrophil adhesion and activation. Tissue oxygen levels have been shown to be significantly increased by therapeutic doses of pentoxifylline in patients with peripheral arterial disease (La Phamacopee en Mesotherapie, 2001). Mesotherapists believe that by increasing microcirculation of localized tissue beds, elimination of metabolic waste is more efficient and there is an increase in the delivery of the mesotherapeutic solutions as well as oxygen and nutrients in general circulation, thereby encouraging healing. Injecting pentoxifylline mesotherapeutically is believed to exercise its therapeutic effect for a continued period of time compared with per os or a deeper injection (LeCoz, 1993).
Peripheral Arterial Thromboembolic Disorders
Hau C. Kwaan, Meyer M. Samama in Clinical Thrombosis, 2019
The above facts have brought about a considerable reduction in the use of vasoactive drugs for vascular patients. However, there still is a great variety of vasodilators on the market. In Europe substances such as bencyclane (Fludilat®), beta-pyridil carbinol (Ronicol®), buflomedil (Bufedil®), flunarizine (Sibelium®), xantinol-nicotinate (Complamin®), naphtidrofuryl (Dusodril®, Praxilene®), pentoxifylline (Trental®), and cinnarizin (Stutgeron®) are used to alleviate circulation disorders (for a critical evaluation see Verstraete17). Naphtidrofuryl and pentoxifylline are the drugs most frequently prescribed.
Reduction mammoplasty and mastopexy in the previously irradiated breast – a systematic review and meta-analysis
Published in Journal of Plastic Surgery and Hand Surgery, 2021
Anne Kathrine Lorentzen, Jørgen Lock-Andersen, Louise Wichmann Matthiessen, Tobias Wirenfeldt Klausen, Lisbet Rosenkrantz Hölmich
Attempts at reducing postoperative complications by using prophylactic measures have been described. Snyder et al. [50] reported data on five patients treated with reduction mammoplasty on previously irradiated breasts, combined with adjuvant hyperbaric oxygen therapy pre- and postoperatively. Delayed wound healing was reported in two irradiated and two non-irradiated breasts, but no further complications were seen. Hyperbaric oxygen therapy increases angiogenesis and vascularization and may prove beneficial in reducing postoperative complications. However, the feasibility of this protocol limits its clinical use, and evidence for this preventive measure is lacking. In another case report, Sterodimas et al. [51] used buflomedil (a vasoactive agent that increases microcirculation) in a patient undergoing bilateral breast reduction after unilateral lumpectomy and irradiation. Buflomedil was administered intravenously for 2 days, followed by a 14-day oral course. No complications were seen. With only one study investigating the benefit of buflomedil in reducing postoperative complications, further studies are needed.
Use of calcium channel blockers in dermatology: a narrative review
Published in Expert Review of Clinical Pharmacology, 2021
Yang Lo, Lian-Yu Lin, Tsen-Fang Tsai
In one case, oral nifedipine 20 mg three times a day was given to treat atrophie blanche with success [10]. Buflomedil hydrochloride, a weak CCB and alpha-adrenoceptor antagonist, can be administered orally 150 mg, 3–4 times daily for atrophie blanche [11].
Related Knowledge Centers
- Adverse Effect
- Cardiotoxicity
- Claudication
- Neurotoxicity
- Vasoactivity
- Peripheral Artery Disease